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Database: UniProt/TrEMBL
Entry: D5GH50_TUBMM
LinkDB: D5GH50_TUBMM
Original site: D5GH50_TUBMM 
ID   D5GH50_TUBMM            Unreviewed;       991 AA.
AC   D5GH50;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   25-OCT-2017, entry version 45.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=GSTUM_00007703001 {ECO:0000313|EMBL:CAZ83843.1};
OS   Tuber melanosporum (strain Mel28) (Perigord black truffle).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Tuberaceae; Tuber.
OX   NCBI_TaxID=656061 {ECO:0000313|EMBL:CAZ83843.1, ECO:0000313|Proteomes:UP000006911};
RN   [1] {ECO:0000313|EMBL:CAZ83843.1, ECO:0000313|Proteomes:UP000006911}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mel28 {ECO:0000313|EMBL:CAZ83843.1,
RC   ECO:0000313|Proteomes:UP000006911};
RX   PubMed=20348908; DOI=10.1038/nature08867;
RA   Martin F., Kohler A., Murat C., Balestrini R., Coutinho P.M.,
RA   Jaillon O., Montanini B., Morin E., Noel B., Percudani R., Porcel B.,
RA   Rubini A., Amicucci A., Amselem J., Anthouard V., Arcioni S.,
RA   Artiguenave F., Aury J.M., Ballario P., Bolchi A., Brenna A., Brun A.,
RA   Buee M., Cantarel B., Chevalier G., Couloux A., Da Silva C.,
RA   Denoeud F., Duplessis S., Ghignone S., Hilselberger B., Iotti M.,
RA   Marcais B., Mello A., Miranda M., Pacioni G., Quesneville H.,
RA   Riccioni C., Ruotolo R., Splivallo R., Stocchi V., Tisserant E.,
RA   Viscomi A.R., Zambonelli A., Zampieri E., Henrissat B., Lebrun M.H.,
RA   Paolocci F., Bonfante P., Ottonello S., Wincker P.;
RT   "Perigord black truffle genome uncovers evolutionary origins and
RT   mechanisms of symbiosis.";
RL   Nature 464:1033-1038(2010).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; FN430297; CAZ83843.1; -; Genomic_DNA.
DR   RefSeq; XP_002839652.1; XM_002839606.1.
DR   UniGene; Tme.2866; -.
DR   ProteinModelPortal; D5GH50; -.
DR   STRING; 39416.CAZ83843; -.
DR   EnsemblFungi; CAZ83843; CAZ83843; GSTUM_00007703001.
DR   GeneID; 9185097; -.
DR   KEGG; tml:GSTUM_00007703001; -.
DR   InParanoid; D5GH50; -.
DR   KO; K10777; -.
DR   OMA; HMCPSTK; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000006911; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006911};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006911}.
FT   DOMAIN      417    542       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      715    800       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      919    982       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      658    685       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   991 AA;  113000 MW;  F9AB8C6AA89EBB71 CRC64;
     MSDIDDIDLP DIPRAPVDPS GDTFGPNVIL SDSDLDKAYP NRPRNKNPTL PFADLYLSLF
     EPLLANKKKR TGVSIRGTNK VLKPHEIRRN IIDRFISRWR NEVGNDIYPT LRLILCEKDR
     DRSVYHLKEK TIGRLLVKVM KINKDSDDGY SLINWKQPGT SKSAGDFALR CYEIIRKRPM
     RTTPGSLTIS QVNSMLDRLS LASKEEEQLP IMTEFYNNMN ASELMWLIRI IMRQMKVGAT
     ERTFFDAWHP DAAALFNISS SLKRVCWELS DPEFRMDSDG KSVSLMSCFQ PQLAQFQKRS
     LDDAVKAMHL TPEDPIFWIE EKLDGERMQM HYENGNFMFW SRKAKDYTRL YGSCFDDGSL
     TRHLRGAFDD GVKSIILDGE MITWDPRLDC IVAFGTLKTA ALEGIRNPFG DGPRPLFKVF
     DILHLNGGCL INYSLRDRRM ALERSVKTID RRMEVHKYEE AREAVEIERA LRKVIAEASE
     GLVIKNPRSI YRLNDRNDDW MKVKPEYMTE FGESLDLVVL GGYWGSGTRG GILSSYLCGL
     RVDGNHLKPG EDPMKFRSFC KVGGGFTAND YSKIAHMTDS QWVPWDPKKP PSEHIEIVAG
     GRGVDQPDVW IRPDKSIVLE VKAASIVPTD EFRVGKSLRF PRFRQIREDK DWQTALSISE
     LIALKEEVEK EKADEEKRIE VENRTRRAGK RMKREYTVLG ASDKPADFVS PTVEGGPRLF
     EGRSFYVMSD ATTPKKMGKA EVEQLIKSHG GNLYQTENAV PDTNVIGDKN NVKISALKKK
     GTHDVIRPAW IFDCIRQHEL DLQRGQKGCY IIPIEARHIL HAASGVERRA AASVDQFGDS
     YARDLTMEEI SNLLRDMPGA FDRTFASEFV KGLSEHDQRE LGELPGWMFK TFVIYVDREG
     QGEVNENLKP SPLLALFAGA RIALDLQDTE ITHIIASHDQ QRLHELREAI KWRPRIPRIV
     TRDWLKSSLE ARTVLDEEQF SPALGCVTGS A
//
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