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Database: UniProt/TrEMBL
Entry: D5T1I2_LEUKI
LinkDB: D5T1I2_LEUKI
Original site: D5T1I2_LEUKI 
ID   D5T1I2_LEUKI            Unreviewed;       427 AA.
AC   D5T1I2;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   OrderedLocusNames=LKI_02940 {ECO:0000313|EMBL:ADG40131.1};
OS   Leuconostoc kimchii (strain IMSNU 11154 / KCTC 2386 / IH25).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Leuconostoc.
OX   NCBI_TaxID=762051 {ECO:0000313|EMBL:ADG40131.1, ECO:0000313|Proteomes:UP000002362};
RN   [1] {ECO:0000313|EMBL:ADG40131.1, ECO:0000313|Proteomes:UP000002362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IMSNU 11154 / KCTC 2386 / IH25
RC   {ECO:0000313|Proteomes:UP000002362};
RX   PubMed=20494991; DOI=10.1128/JB.00508-10;
RA   Oh H.M., Cho Y.J., Kim B.K., Roe J.H., Kang S.O., Nahm B.H., Jeong G.,
RA   Han H.U., Chun J.;
RT   "Complete genome sequence analysis of Leuconostoc kimchii IMSNU 11154.";
RL   J. Bacteriol. 192:3844-3845(2010).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|ARBA:ARBA00001938,
CC         ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; CP001758; ADG40131.1; -; Genomic_DNA.
DR   RefSeq; WP_013102728.1; NC_014136.1.
DR   AlphaFoldDB; D5T1I2; -.
DR   STRING; 762051.LKI_02940; -.
DR   KEGG; lki:LKI_02940; -.
DR   PATRIC; fig|762051.18.peg.593; -.
DR   eggNOG; COG0508; Bacteria.
DR   HOGENOM; CLU_016733_10_0_9; -.
DR   OrthoDB; 9805770at2; -.
DR   Proteomes; UP000002362; Chromosome.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   CDD; cd06849; lipoyl_domain; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 4.10.320.10; E3-binding domain; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR036625; E3-bd_dom_sf.
DR   InterPro; IPR004167; PSBD.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR   PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF02817; E3_binding; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR   SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR   SUPFAM; SSF51230; Single hybrid motif; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS51826; PSBD; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003423}; Lipoyl {ECO:0000256|RuleBase:RU003423};
KW   Transferase {ECO:0000256|RuleBase:RU003423, ECO:0000313|EMBL:ADG40131.1}.
FT   DOMAIN          2..77
FT                   /note="Lipoyl-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50968"
FT   DOMAIN          123..160
FT                   /note="Peripheral subunit-binding (PSBD)"
FT                   /evidence="ECO:0000259|PROSITE:PS51826"
SQ   SEQUENCE   427 AA;  45829 MW;  4F82A4A39ADE96DE CRC64;
     MTEIFTMPDI GEGMAEGDIT SWLVKVGDVV AMDDPVAEVQ NDKLLQEILS PYAGKVTHLY
     VDAGTTVEVG DPLIEFDGSG TPDTGSDEKT VVETTAPSSE DEVPLVTSDD TTQMVKVANG
     HVLAMPSVRH LAFEKGIDLT TVTPTGRHGH VTLSDVESFN KENVSESQAV APVEVATQQG
     TKPNDITPKA PEVLHEGRQP MTPTRRAIAK AMGAQNATIP SVTNFDSVEV SKLVAHRSSF
     KAQAQADGVR LTYLAYAVKA LAATAKKFPE INASVDMDTN EIIYHEDVNM GIAVNAPSGL
     YVPVIMHADQ KSILTIAKEI VELSEAVREG SITSQQMRGS TITISNLGSA RGTWFTPIIN
     GKEVAILGLG TIVKEPMIDE NDDIVVGQNM KLSLSYDHRL IDGMLGQAAL NYLKQLLADP
     AYMLMEV
//
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