GenomeNet

Database: UniProt/TrEMBL
Entry: D6AZ66_9ACTN
LinkDB: D6AZ66_9ACTN
Original site: D6AZ66_9ACTN 
ID   D6AZ66_9ACTN            Unreviewed;       698 AA.
AC   D6AZ66;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   28-MAR-2018, entry version 58.
DE   RecName: Full=Catalase {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
GN   ORFNames=SSHG_01451 {ECO:0000313|EMBL:EFE81009.2};
OS   Streptomyces albus J1074.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=457425 {ECO:0000313|EMBL:EFE81009.2, ECO:0000313|Proteomes:UP000005105};
RN   [1] {ECO:0000313|Proteomes:UP000005105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J1074 {ECO:0000313|Proteomes:UP000005105};
RA   Molnar K.;
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000005105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J1074 {ECO:0000313|Proteomes:UP000005105};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Ward D., Young S., Kodira C.D., Zeng Q., Koehrsen M.,
RA   Godfrey P., Alvarado L., Berlin A.M., Borenstein D., Chen Z.,
RA   Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B.,
RA   Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.D.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J.,
RA   Yandava C., Straight P., Clardy J., Hung D., Kolter R., Mekalanos J.,
RA   Walker S., Walsh C.T., Wieland B.L.C., Ilzarbe M., Galagan J.,
RA   Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces albus strain J1074.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Serves to protect cells from the toxic effects of
CC       hydrogen peroxide. {ECO:0000256|PIRNR:PIRNR038927}.
CC   -!- CATALYTIC ACTIVITY: 2 H(2)O(2) = O(2) + 2 H(2)O.
CC       {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRNR:PIRNR038927,
CC         ECO:0000256|PIRSR:PIRSR038927-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; DS999645; EFE81009.2; -; Genomic_DNA.
DR   RefSeq; WP_003947889.1; NZ_DS999645.1.
DR   ProteinModelPortal; D6AZ66; -.
DR   STRING; 457425.SSHG_01451; -.
DR   EnsemblBacteria; EFE81009; EFE81009; SSHG_01451.
DR   KEGG; salb:XNR_4489; -.
DR   PATRIC; fig|457425.27.peg.4634; -.
DR   eggNOG; ENOG4105CH6; Bacteria.
DR   eggNOG; COG0753; LUCA.
DR   KO; K03781; -.
DR   BioCyc; SALB457425:G1HGK-4564-MONOMER; -.
DR   Proteomes; UP000005105; Unassembled WGS sequence.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 2.40.180.10; -; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024712; Catalase_clade2.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR037060; Catalase_core_sf.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR002818; DJ-1/PfpI.
DR   PANTHER; PTHR42821; PTHR42821; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   Pfam; PF01965; DJ-1_PfpI; 1.
DR   PIRSF; PIRSF038927; Catalase_clade2; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005105};
KW   Heme {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
KW   Hydrogen peroxide {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|PIRSR:PIRSR038927-2,
KW   ECO:0000256|RuleBase:RU000498};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|PIRSR:PIRSR038927-2, ECO:0000256|RuleBase:RU000498};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498};
KW   Peroxidase {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498}.
FT   ACT_SITE     75     75       {ECO:0000256|PIRSR:PIRSR038927-1}.
FT   ACT_SITE    148    148       {ECO:0000256|PIRSR:PIRSR038927-1}.
FT   METAL       362    362       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR038927-2}.
SQ   SEQUENCE   698 AA;  77109 MW;  55AF057FDD0E4205 CRC64;
     MAQNKSPDPK QRQRAEALAP DPCGGPLTTD QGVTVEHTDD SLRAGERGPT LLEDFHFREK
     ITRFDHERIP ERVVHARGAG AYGYFEPYAS CAEFTRAAFL QDPAVRTPVF VRFSTVQGPR
     GSADTVRDVR GFATKFYTSE GNYDLVGNNF PVFFIQDGIK FPDFVHAVKM EPHNEIPTGA
     SAHDTLWDFV SLQPETLHTI MWLMSDRAIP RSYRMMQGFG VHTFRFVDAA GKGTFVKFHW
     KPKLGVHSLV WDEAQEVMGR DPDFNRRDLW DTIEAGQYPE WELGVQLVPE ADEHKFDFDL
     LDATKIIPEE QVPVRPIGRM VLDRNPDNFF AETEQIAFCT ANVVPGIDFT NDPLLQARNF
     SYLDTQLIRL GGPNFAHIPV NRPVVDVRNN QRDGYHQEEI HRGTNYSPNS LGGGCPALGS
     VDEGAYRHLA ERVDGVKIRK RSPSFDDHYT QAALFWHSMA GWEKQHIVDA FRFELGKVGA
     VPVRERTVEQ LARVDHELAT AVAEGIGVAA PARQETPSPQ PSPALSFENN QGESTIATRQ
     IALLVTDGVD AHQATVLRDT LRERGAVAEV LAPHDGTVRA ADGSPLTVDR ALPTVAAVLY
     DAVVLTDGSE PGDGSDGDAA RRFVRNAYRH GKPVAAYGSA TALLTRLLPD GLRLSTPDGE
     VTADRGVVSG GTADSPFTEE LVKAVAAHRF RDRPAPRA
//
DBGET integrated database retrieval system