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Database: UniProt/TrEMBL
Entry: D6B9G6_9ACTN
LinkDB: D6B9G6_9ACTN
Original site: D6B9G6_9ACTN 
ID   D6B9G6_9ACTN            Unreviewed;       740 AA.
AC   D6B9G6;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   07-JUN-2017, entry version 51.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:EFE80256.2};
GN   ORFNames=SSHG_00698 {ECO:0000313|EMBL:EFE80256.2};
OS   Streptomyces albus J1074.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=457425 {ECO:0000313|EMBL:EFE80256.2, ECO:0000313|Proteomes:UP000005105};
RN   [1] {ECO:0000313|Proteomes:UP000005105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J1074 {ECO:0000313|Proteomes:UP000005105};
RA   Molnar K.;
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000005105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J1074 {ECO:0000313|Proteomes:UP000005105};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center;
RA   Fischbach M., Ward D., Young S., Kodira C.D., Zeng Q., Koehrsen M.,
RA   Godfrey P., Alvarado L., Berlin A.M., Borenstein D., Chen Z.,
RA   Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Lewis B.,
RA   Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.D.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J.,
RA   Yandava C., Straight P., Clardy J., Hung D., Kolter R., Mekalanos J.,
RA   Walker S., Walsh C.T., Wieland B.L.C., Ilzarbe M., Galagan J.,
RA   Nusbaum C., Birren B.;
RT   "Annotation of Streptomyces albus strain J1074.";
RL   Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; DS999645; EFE80256.2; -; Genomic_DNA.
DR   RefSeq; WP_003947137.1; NZ_DS999645.1.
DR   ProteinModelPortal; D6B9G6; -.
DR   STRING; 457425.SSHG_00698; -.
DR   EnsemblBacteria; EFE80256; EFE80256; SSHG_00698.
DR   GeneID; 31256000; -.
DR   KEGG; salb:XNR_5251; -.
DR   PATRIC; fig|457425.27.peg.5416; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   Proteomes; UP000005105; Unassembled WGS sequence.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005105};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       547    547       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       551    551       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     546    546       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   740 AA;  79273 MW;  3F14FC5A5A71685E CRC64;
     MTDSTIFYTH TDEAPALATY SFLPVVEAYA STAGVTVERR DISLAGRIIA SFPERLAEGQ
     RIEDALAELG ELAKTPQANI IKLPNISASI PQLKAAIAEL QGQGYALPDY PDDPKTDEDK
     DVRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKAHPH RMGAWTADSK TNVATMGVDD
     FRSTEKSAVV AEDGTLRIEL VGDDGSTTVL RESVPVLAGE VVDASVLRVA ALREFLTAQI
     AKAKAEDVLF SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGPALAAAG LSPNDGLGGI
     YKGLEGLAEG AEIKASFDAE LAEGPALAMV DSDRGISNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGEEAD TLAVLPDSSY AGVYQAVIED CRANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEVPTT GTVRVVDTKS GEAVLEQTVG AGDIFRMCQT KDAPIKDWVK LAVTRARATG
     NPAVFWLDED RAHDARLIEK VQAYLPEHDT EGLEIKILSP VEATRFSLER IRRGEDTISV
     TGNVLRDYLT DLFPILELGT SAKMLSVVPL MNGGGLFETG AGGSAPKHVQ QLVKEDYLRW
     DSLGEFLALA VSFEHLAQTT GNARAQVLAD TLDRATGTFL NEDKSPSRKL GGIDNRGSHF
     YLALYWAQEL AQQTDDAQLA EAFAPLAATL AEQEGTIVAE LAAVQGKPVD IGGYYQPDPA
     KAEAVMRPSK TLNQAIATLA
//
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