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Database: UniProt/TrEMBL
Entry: D6EDR8_STRLI
LinkDB: D6EDR8_STRLI
Original site: D6EDR8_STRLI 
ID   D6EDR8_STRLI            Unreviewed;       739 AA.
AC   D6EDR8;
DT   13-JUL-2010, integrated into UniProtKB/TrEMBL.
DT   13-JUL-2010, sequence version 1.
DT   07-JUN-2017, entry version 39.
DE   SubName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000313|EMBL:AIJ11872.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:AIJ11872.1};
GN   Name=icd {ECO:0000313|EMBL:AIJ11872.1};
GN   ORFNames=SLIV_04245 {ECO:0000313|EMBL:AIJ11872.1};
OS   Streptomyces lividans TK24.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=457428 {ECO:0000313|EMBL:AIJ11872.1, ECO:0000313|Proteomes:UP000028682};
RN   [1] {ECO:0000313|EMBL:AIJ11872.1, ECO:0000313|Proteomes:UP000028682}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TK24 {ECO:0000313|EMBL:AIJ11872.1,
RC   ECO:0000313|Proteomes:UP000028682};
RG   StrepSynth;
RA   Ruckert C., Fridjonson O.H., Lambert C., van Wezel G.P., Bernaerts K.,
RA   Anne J., Economou A., Kalinowski J.;
RT   "Complete genome sequence of Streptomyces lividans TK24.";
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP009124; AIJ11872.1; -; Genomic_DNA.
DR   RefSeq; WP_003972144.1; NZ_GG657756.1.
DR   EnsemblBacteria; AIJ11872; AIJ11872; SLIV_04245.
DR   GeneID; 29662276; -.
DR   KEGG; slv:SLIV_04245; -.
DR   PATRIC; fig|457428.16.peg.910; -.
DR   KO; K00031; -.
DR   Proteomes; UP000028682; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028682};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:AIJ11872.1}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79534 MW;  DCDF3EAD6B6C4FA3 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA LFPEYLTEDQ
     RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAVAEL QGQGYALPAY PDDPKTDEER
     DIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWTGESK TNVATMGEND
     FRSTEKSAVI AEDGTLRIEL VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV
     ARAKAEGILY SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGDVLAKAG LTPNDGLGGI
     YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS MPAMIRTSGH
     MWGADGGEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEIPTT GTVRLVDAAG NAVLEQTVSA GDIFRACQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDEGR AHDANLIAKV KQYLTEHDTE GLDIRILDPV EATKLSVERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKEDYLRWD
     SLGEFFALVP SLEKYAEATG NGKAKVLADT LDRATATFLN EDKSPTRRVG GIDNRGSHFY
     LSLYWAQELA KQTDDADLAK AFAPLAETLT ASEQKIVEEL NAVQGKPAEI GGYYQPDPAK
     AAKIMRPSTT WNEALASLA
//
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