GenomeNet

Database: UniProt/TrEMBL
Entry: D6WZP0_TRICA
LinkDB: D6WZP0_TRICA
Original site: D6WZP0_TRICA 
ID   D6WZP0_TRICA            Unreviewed;      1740 AA.
AC   D6WZP0;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   25-APR-2018, entry version 55.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EFA10454.1};
GN   ORFNames=TcasGA2_TC012700 {ECO:0000313|EMBL:EFA10454.1};
OS   Tribolium castaneum (Red flour beetle).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga;
OC   Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium.
OX   NCBI_TaxID=7070 {ECO:0000313|EMBL:EFA10454.1, ECO:0000313|Proteomes:UP000007266};
RN   [1] {ECO:0000313|EMBL:EFA10454.1, ECO:0000313|Proteomes:UP000007266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA10454.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=18362917; DOI=10.1038/nature06784;
RG   Tribolium Genome Sequencing Consortium;
RA   Richards S., Gibbs R.A., Weinstock G.M., Brown S.J., Denell R.,
RA   Beeman R.W., Gibbs R., Beeman R.W., Brown S.J., Bucher G.,
RA   Friedrich M., Grimmelikhuijzen C.J., Klingler M., Lorenzen M.,
RA   Richards S., Roth S., Schroder R., Tautz D., Zdobnov E.M., Muzny D.,
RA   Gibbs R.A., Weinstock G.M., Attaway T., Bell S., Buhay C.J.,
RA   Chandrabose M.N., Chavez D., Clerk-Blankenburg K.P., Cree A., Dao M.,
RA   Davis C., Chacko J., Dinh H., Dugan-Rocha S., Fowler G., Garner T.T.,
RA   Garnes J., Gnirke A., Hawes A., Hernandez J., Hines S., Holder M.,
RA   Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Jackson L., Kovar C.,
RA   Kowis A., Lee S., Lewis L.R., Margolis J., Morgan M., Nazareth L.V.,
RA   Nguyen N., Okwuonu G., Parker D., Richards S., Ruiz S.J.,
RA   Santibanez J., Savard J., Scherer S.E., Schneider B., Sodergren E.,
RA   Tautz D., Vattahil S., Villasana D., White C.S., Wright R., Park Y.,
RA   Beeman R.W., Lord J., Oppert B., Lorenzen M., Brown S., Wang L.,
RA   Savard J., Tautz D., Richards S., Weinstock G., Gibbs R.A., Liu Y.,
RA   Worley K., Weinstock G., Elsik C.G., Reese J.T., Elhaik E., Landan G.,
RA   Graur D., Arensburger P., Atkinson P., Beeman R.W., Beidler J.,
RA   Brown S.J., Demuth J.P., Drury D.W., Du Y.Z., Fujiwara H.,
RA   Lorenzen M., Maselli V., Osanai M., Park Y., Robertson H.M., Tu Z.,
RA   Wang J.J., Wang S., Richards S., Song H., Zhang L., Sodergren E.,
RA   Werner D., Stanke M., Morgenstern B., Solovyev V., Kosarev P.,
RA   Brown G., Chen H.C., Ermolaeva O., Hlavina W., Kapustin Y.,
RA   Kiryutin B., Kitts P., Maglott D., Pruitt K., Sapojnikov V.,
RA   Souvorov A., Mackey A.J., Waterhouse R.M., Wyder S., Zdobnov E.M.,
RA   Zdobnov E.M., Wyder S., Kriventseva E.V., Kadowaki T., Bork P.,
RA   Aranda M., Bao R., Beermann A., Berns N., Bolognesi R., Bonneton F.,
RA   Bopp D., Brown S.J., Bucher G., Butts T., Chaumot A., Denell R.E.,
RA   Ferrier D.E., Friedrich M., Gordon C.M., Jindra M., Klingler M.,
RA   Lan Q., Lattorff H.M., Laudet V., von Levetsow C., Liu Z., Lutz R.,
RA   Lynch J.A., da Fonseca R.N., Posnien N., Reuter R., Roth S.,
RA   Savard J., Schinko J.B., Schmitt C., Schoppmeier M., Schroder R.,
RA   Shippy T.D., Simonnet F., Marques-Souza H., Tautz D., Tomoyasu Y.,
RA   Trauner J., Van der Zee M., Vervoort M., Wittkopp N., Wimmer E.A.,
RA   Yang X., Jones A.K., Sattelle D.B., Ebert P.R., Nelson D., Scott J.G.,
RA   Beeman R.W., Muthukrishnan S., Kramer K.J., Arakane Y., Beeman R.W.,
RA   Zhu Q., Hogenkamp D., Dixit R., Oppert B., Jiang H., Zou Z.,
RA   Marshall J., Elpidina E., Vinokurov K., Oppert C., Zou Z., Evans J.,
RA   Lu Z., Zhao P., Sumathipala N., Altincicek B., Vilcinskas A.,
RA   Williams M., Hultmark D., Hetru C., Jiang H., Grimmelikhuijzen C.J.,
RA   Hauser F., Cazzamali G., Williamson M., Park Y., Li B., Tanaka Y.,
RA   Predel R., Neupert S., Schachtner J., Verleyen P., Raible F., Bork P.,
RA   Friedrich M., Walden K.K., Robertson H.M., Angeli S., Foret S.,
RA   Bucher G., Schuetz S., Maleszka R., Wimmer E.A., Beeman R.W.,
RA   Lorenzen M., Tomoyasu Y., Miller S.C., Grossmann D., Bucher G.;
RT   "The genome of the model beetle and pest Tribolium castaneum.";
RL   Nature 452:949-955(2008).
RN   [2] {ECO:0000313|EMBL:EFA10454.1, ECO:0000313|Proteomes:UP000007266}
RP   GENOME REANNOTATION.
RC   STRAIN=Georgia GA2 {ECO:0000313|EMBL:EFA10454.1,
RC   ECO:0000313|Proteomes:UP000007266};
RX   PubMed=19820115; DOI=10.1093/nar/gkp807;
RA   Kim H.S., Murphy T., Xia J., Caragea D., Park Y., Beeman R.W.,
RA   Lorenzen M.D., Butcher S., Manak J.R., Brown S.J.;
RT   "BeetleBase in 2010: revisions to provide comprehensive genomic
RT   information for Tribolium castaneum.";
RL   Nucleic Acids Res. 38:D437-D442(2010).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; KQ971372; EFA10454.1; -; Genomic_DNA.
DR   RefSeq; XP_008198269.1; XM_008200047.2.
DR   STRING; 7070.TC012700-PA; -.
DR   EnsemblMetazoa; TC012700_001; TC012700_001; TC012700.
DR   GeneID; 662527; -.
DR   KEGG; tca:662527; -.
DR   eggNOG; KOG1081; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   InParanoid; D6WZP0; -.
DR   KO; K11424; -.
DR   PhylomeDB; D6WZP0; -.
DR   Proteomes; UP000007266; Linkage group 9.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00855; PWWP; 2.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00249; PHD; 4.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00293; PWWP; 2.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF57903; SSF57903; 2.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50812; PWWP; 2.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007266};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01011399};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007266};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533};
KW   Zinc {ECO:0000256|SAAS:SAAS01006535};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00146,
KW   ECO:0000256|SAAS:SAAS01007077}.
FT   DOMAIN      573    637       PWWP. {ECO:0000259|PROSITE:PS50812}.
FT   DOMAIN     1126   1171       PHD-type. {ECO:0000259|PROSITE:PS50016}.
FT   DOMAIN     1176   1238       PWWP. {ECO:0000259|PROSITE:PS50812}.
FT   DOMAIN     1308   1358       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     1360   1477       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     1484   1500       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   COILED      694    721       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1740 AA;  195343 MW;  7F8674C03A212442 CRC64;
     MASPQACLSS SPEIVSPGGK SRYGRTRRPK ISHDFCNIDD VIIDDNPPEV KSPLKARDVV
     FEIKDEFTKL DDLGMKVANN FKTNRGLDAS IKERKFFKSA VVSKAVDVVD VSKVLKLVST
     PGAEAQAKSP PKTVLKTYSN RRKHAENERV VESFGLPDEP IIPVKGHAFQ RHSKIDVDFA
     AENDVSLPNP WTFDEIFTNE MKGPTNGETF DENTDFQQTL TPKGAKNAFE RTTGKKRLFR
     SSAEEGGTIV TVSPVLKKAK VGSSPPKRVL RSNFESNVKI QSSVSPQNET NDSVVEAELP
     SAGNESEEEL PNISHKSLRS STLKNKSPEK RIEISHEKNK IKTKSPEKCK PKKGLNLVKT
     AKEISTETNK IRVGGTECTV KNKSPKKSKT KEALNPVVTV EEISPEKNNV QDDAAEENPL
     KNGSSGKSKT KEALNPVKMV KTSAEKNDGL EAVTKSALTM TQTKTKEVFN PVVIVTEISP
     EKNNVQEDVA ENRTEESGPK NKPKEVFLNP VIIMKEFSAV KNDGPEAAES EPSMTQSKTK
     EVLEISAETN QVPENETKEE LKVIKQEVIE LEVGVLAWAK LGNFPYWPCL ITQEPASGTH
     QKYVVNRIHP LYHVRFFGDK GRRSWVHGPN VMPFYAKDDL ERLAKTLEVE GKFKPSYINE
     CCFIRRTLMK KWQEGVAEAE SLQFKTVDER LNYFSKMFAR KNELKQERQK LKRARLSAAE
     NLSKKVKIEE IETLELIKPE PVEVTSSPDT LIKPPKKKNF LKKEEFSDEQ LEARKKLRNP
     QVREEIPQPS SAPKLRKKPQ GENSNSDTDS KFSDNSSLPP SMQSQAALFR RNNIFRGIPR
     EKVCQICEKS GEIFKCKGPC NGVYHPECAM NRVVEQKSSV EIISLESKQP LPDLGTSPNY
     TGMSLAEKID HRMKEIMKKF DQSVYCESTD SSSDEYVVEE VVRQASPPAQ SKLSLTVTAT
     PTKKEVPIIK HVTADNISYI CVSNEAPKED TTGLKCTWCA SDEAPLCLVC GEMGAQGRQK
     CSLHQCGRFY HPECLKLWPQ TQWSLNASDS FVCPRHVCHT CISDDPRAAN SRCSSDKIVK
     CLKCPATYHS SNYCVPAGTE ILTASQIICP RHFTRNKRNY QSTINANWCF ICSNGGDLIC
     CETCPTSVHR ECLPGDLGEV ETFFCEDCQS GRLPLYDEIV WVKLGSFRWW PAVILFPNEV
     PDNVKNIPHS KGEFVVKFYG TYDHYWVGRG RTFLFQEGDR GHSGSVKKRV DNAFVKAIEE
     AAAAHELKKQ FKARKFEEKN SGMKPPPYVR IKVNKPVGNV RVFDGNTSNT TSCDCDPNQP
     HPCGPDSDCL NRLLLTECNP DVCPAGDRCN NQCFEKREYP PLVPHRTLYR GWGLKTLAPI
     RKGQFVIEYV GEMIDEQEYQ RRVQKMHEQK EENYYFLTID KDRMLDAGPK GNVARFMNHS
     CDPNCETQKW TVNGDTRVGL FANCDIPAGT ELTFNYNLEC IGKEKKICHC GAPNCSGFIG
     VKVKTDNPPK KSTKAKKKKT PPLEYVDNDN PCFICGKQGD VAACNNKICT KYYHLACVGL
     EAWPEGNKWV CQWHNCNICT KRTIRCCVRC INSYCPSHSD GNVRYDKLLG FVCSEHDSSK
     ESNAVVTSHV PAPDSCVSDE GVVTSTTSDD SRMNGFVTST PVKKNDNSYD ESVVSSSEKK
     PKKVKKKKVE NTANFLLENE VKLNNFAPVK YLRTSRSRNS DPERDLPIRK RTRLRCGSSL
//
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