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Database: UniProt/TrEMBL
Entry: D6ZSQ7_STRP0
LinkDB: D6ZSQ7_STRP0
Original site: D6ZSQ7_STRP0 
ID   D6ZSQ7_STRP0            Unreviewed;       898 AA.
AC   D6ZSQ7;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   27-SEP-2017, entry version 55.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635171};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635171};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595,
GN   ECO:0000313|EMBL:ADI69646.1};
GN   OrderedLocusNames=HMPREF0837_11418 {ECO:0000313|EMBL:ADI69646.1};
OS   Streptococcus pneumoniae serotype A19 (strain TCH8431).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=525381 {ECO:0000313|EMBL:ADI69646.1, ECO:0000313|Proteomes:UP000009083};
RN   [1] {ECO:0000313|Proteomes:UP000009083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TCH8431 {ECO:0000313|Proteomes:UP000009083};
RX   PubMed=20489017; DOI=10.1126/science.1183605;
RA   Nelson K.E., Weinstock G.M., Highlander S.K., Worley K.C.,
RA   Creasy H.H., Wortman J.R., Rusch D.B., Mitreva M., Sodergren E.,
RA   Chinwalla A.T., Feldgarden M., Gevers D., Haas B.J., Madupu R.,
RA   Ward D.V., Birren B.W., Gibbs R.A., Methe B., Petrosino J.F.,
RA   Strausberg R.L., Sutton G.G., White O.R., Wilson R.K., Durkin S.,
RA   Giglio M.G., Gujja S., Howarth C., Kodira C.D., Kyrpides N., Mehta T.,
RA   Muzny D.M., Pearson M., Pepin K., Pati A., Qin X., Yandava C.,
RA   Zeng Q., Zhang L., Berlin A.M., Chen L., Hepburn T.A., Johnson J.,
RA   McCorrison J., Miller J., Minx P., Nusbaum C., Russ C., Sykes S.M.,
RA   Tomlinson C.M., Young S., Warren W.C., Badger J., Crabtree J.,
RA   Markowitz V.M., Orvis J., Cree A., Ferriera S., Fulton L.L.,
RA   Fulton R.S., Gillis M., Hemphill L.D., Joshi V., Kovar C.,
RA   Torralba M., Wetterstrand K.A., Abouellleil A., Wollam A.M.,
RA   Buhay C.J., Ding Y., Dugan S., FitzGerald M.G., Holder M.,
RA   Hostetler J., Clifton S.W., Allen-Vercoe E., Earl A.M., Farmer C.N.,
RA   Liolios K., Surette M.G., Xu Q., Pohl C., Wilczek-Boney K., Zhu D.;
RT   "A catalog of reference genomes from the human microbiome.";
RL   Science 328:994-999(2010).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle. {ECO:0000256|HAMAP-
CC       Rule:MF_00595, ECO:0000256|SAAS:SAAS00730191}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000256|HAMAP-Rule:MF_00595,
CC       ECO:0000256|SAAS:SAAS00635165}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00595, ECO:0000256|SAAS:SAAS00635164};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635168}.
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DR   EMBL; CP001993; ADI69646.1; -; Genomic_DNA.
DR   RefSeq; WP_000058198.1; NC_014251.1.
DR   EnsemblBacteria; ADI69646; ADI69646; HMPREF0837_11418.
DR   KEGG; snc:HMPREF0837_11418; -.
DR   HOGENOM; HOG000238647; -.
DR   KO; K01595; -.
DR   OMA; PWVFGWT; -.
DR   Proteomes; UP000009083; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00635173};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009083};
KW   Kinase {ECO:0000313|EMBL:ADI69646.1};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00635169,
KW   ECO:0000313|EMBL:ADI69646.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00635157};
KW   Pyruvate {ECO:0000313|EMBL:ADI69646.1};
KW   Transferase {ECO:0000313|EMBL:ADI69646.1}.
FT   ACT_SITE    138    138       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10111}.
FT   ACT_SITE    561    561       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10112}.
SQ   SEQUENCE   898 AA;  103280 MW;  2F1E9BE3F09DFF68 CRC64;
     MSLQKLENYS NKSVVQEEVL ILTELLEDIT KNMLAPETFE KIIQLKELST QEDYQGLNRL
     VTSLSNDEMV YISRYFSILP LLINISEDVD LAYEINHQNN IDQDYLGKLS TTIKLVAEKE
     NAVEILEHLN VVPVLTAHPT QVQRKSMLDL TNHIHSLLRK YRDVKLGLIN KDKWYNDLRR
     YIEIIMQTDM IREKKLKVTN EITNAMEYYN SSFLKAVPHL TTEYKRLAQA HGLNLKQAKP
     ITMGMWIGGD RDGNPFVTAK TLKQSALTQC EVIMNYYDKK IYQLYREFSL STSIVNVSKQ
     VREMARQSKD NSIYREKELY RRALFDIQSK IQATKTYLIE DEEVGTRYET ANDFYKDLIA
     IRDSLLENKG ESLISGDFVE LLQAVEIFGF YLASIDMRQD SSVYEACVAE LLKSAGIHSR
     YSELSEEEKC DLLLKELEED PRILSATHAE KSELLAKELA IFKTARVLKD KLGDDVIRQT
     IISHATSLSD MLELAILLKE VGLVDTERAR VQIVPLFETI EDLDHSEETM RKYLSLSLAK
     KWIDSRNNYQ EIMLGYSDSN KDGGYLSSCW TLYKAQQQLT AIGDEFGVKV TFFHGRGGTV
     GRGGGPTYEA ITSQPLKSIK DRIRLTEQGE VIGNKYGNKD AAYYNLEMLV SAAINRMITH
     KKSDTNTPNR YEAIMDQVVD RSYDVYRDLV FGNEHFYDYF FESSPIKAIS SFNIGSRPAA
     RKTITEIGGL RAIPWVFSWS QSRVMFPGWY GVGSSFKEFI NKNPENIAIL RDMYQNWPFF
     QSLLSNVDMV LSKSNMNIAF EYAKLCEDEQ VKAIYETILN EWQVTKNVIL AIEGHDELLA
     DNPYLKASLD YRMPYFNILN YIQLELIKRQ RRGELSSDQE RLIHITINGI ATGLRNSG
//
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