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Database: UniProt/TrEMBL
Entry: D7B558_NOCDD
LinkDB: D7B558_NOCDD
Original site: D7B558_NOCDD 
ID   D7B558_NOCDD            Unreviewed;      1219 AA.
AC   D7B558;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   07-JUN-2017, entry version 44.
DE   SubName: Full=2-oxoglutarate dehydrogenase, E1 subunit {ECO:0000313|EMBL:ADH69079.1};
GN   OrderedLocusNames=Ndas_3681 {ECO:0000313|EMBL:ADH69079.1};
OS   Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / CIP 107115
OS   / JCM 7437 / KCTC 9190 / NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU
OS   509) (Actinomadura dassonvillei).
OC   Bacteria; Actinobacteria; Streptosporangiales; Nocardiopsaceae;
OC   Nocardiopsis.
OX   NCBI_TaxID=446468 {ECO:0000313|EMBL:ADH69079.1, ECO:0000313|Proteomes:UP000002219};
RN   [1] {ECO:0000313|EMBL:ADH69079.1, ECO:0000313|Proteomes:UP000002219}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23218 / DSM 43111 / CIP 107115 / JCM 7437 / KCTC 9190 /
RC   NBRC 14626 / NCTC 10488 / NRRL B-5397 / IMRU 509
RC   {ECO:0000313|Proteomes:UP000002219};
RX   PubMed=21304737; DOI=10.4056/sigs.1363462;
RA   Sun H., Lapidus A., Nolan M., Lucas S., Del Rio T.G., Tice H.,
RA   Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Pagani I.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Djao O.D., Rohde M., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Nocardiopsis dassonvillei type strain
RT   (IMRU 509).";
RL   Stand. Genomic Sci. 3:325-336(2010).
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DR   EMBL; CP002040; ADH69079.1; -; Genomic_DNA.
DR   RefSeq; WP_013154686.1; NC_014210.1.
DR   STRING; 446468.Ndas_3681; -.
DR   EnsemblBacteria; ADH69079; ADH69079; Ndas_3681.
DR   KEGG; nda:Ndas_3681; -.
DR   eggNOG; ENOG4105C7P; Bacteria.
DR   eggNOG; COG0508; LUCA.
DR   eggNOG; COG0567; LUCA.
DR   HOGENOM; HOG000259587; -.
DR   KO; K00164; -.
DR   OMA; IDMVCYR; -.
DR   OrthoDB; POG091H03SK; -.
DR   BioCyc; NDAS446468:GHUM-3671-MONOMER; -.
DR   Proteomes; UP000002219; Chromosome 1.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002219};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002219}.
FT   DOMAIN      879   1072       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
FT   COILED      784    811       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1219 AA;  134997 MW;  07865C67524C8595 CRC64;
     MSSEASQPLT DFGPNEWLVE ELYQKYLNDP NSVDKAWWNF FADYKPAETA GAKGGSGAKA
     QGEKAPAASA PKKKPTAPAA PAPSAKPKSK DDKEGKDEAL QVKQERLRGA PARTATNMES
     SLGLPTATSV RAVPVKLLFD NRIVINNHLR RGRGGKVSFT HLIGYAMVKA LKALPEMNHS
     YVEVDGKPGV AKPEHVNFGL AIDLQKPDGS RQLVVPSIKK SDEMDFTEFW SGYEDLVRKA
     RSNKLGVPDF QGTTISLTNP GGIGTVHSVP RLMPGQGTIL GVGAMEYPAE FQGASSDTLA
     ELGISKVMTL TSTYDHRIIQ GAQSGEFLRR IHQLLLGEDG FYDEIFNSLR IPYEPVRWVQ
     DIHVNKATQL DKTTRVQELI HAYRVRGHLM ADTNPLDHEQ RKHPDLDVLE HGLTLWDLDR
     EFPTGGFGGK QVMKLRDVLG VLRDTYCRTV GIEYMHIQSP EEREWIQAHV EREHEKLDRD
     EQLHILHRLN SAEAFETFLQ TKYVGQKRFS LEGGESLIPL LDGVISKAAK AELDEAVIGM
     AHRGRLNVLA NICGKSYAQI FGEFEGNLDP RSAHGSGDVK YHLGTEGTFE THDGQKIRIS
     LAANPSHLET VDPVAEGIVR AKQDVLNKGP QGFTVLPILI HGDAAFAGQG VVAETLNLSQ
     LRGYRTGGTV HVIVNNQVGF TTSPSDSRSS VYATDVARMV QAPIFHVNGD DPEAVVRVAH
     LAFAYRQAFN KDVVIDLVCY RRRGHNEGDN PAFTQPLMYD VIDAKRSTRK LFTEALIGRG
     DITVEEAESA LRDYQSELER AFTETREVEK KPIEPGSVVK PEVFTEGRLE HSAVETAIST
     ETVKRVIDTQ VSLPEGFTPH PRLAPQLSRR ATMVETDAID WATGELLAFG SLLLDGHPVR
     LIGQDSRRGT FGQRHATLMD RETGETHTPL KQFDDGITRF HVHDSLLSEY AALGFEYGYS
     LTRPDALVMW EAQFGDFVNG AQTIIDEYIS AGEQKWGQRS SVTLLLPHGY EGQGPDHSSA
     RIERFLQQCA QENMTVAHPS TPASYFHLLR WQAKSPLERP LVVFTPKSLL RLKAATSAAA
     DFTSGHFEPL IKDDSIAPDK VRRVVLCSGK IYYDLDAARR KSGDKHTAII RAERLYPLPI
     EEIREQLKAY PNAGEVLWVQ EEPANMGPWP FVALVFSEQL DRPFTRISRP ASSAPAAGSA
     KRHEAEQRAL VDTVFPPAD
//
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