ID D7BRD4_STRBB Unreviewed; 9950 AA.
AC D7BRD4;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Short-chain dehydrogenase/reductase SDR {ECO:0000313|EMBL:ADI05097.1};
GN OrderedLocusNames=SBI_01976 {ECO:0000313|EMBL:ADI05097.1};
OS Streptomyces bingchenggensis (strain BCW-1).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI05097.1, ECO:0000313|Proteomes:UP000000377};
RN [1] {ECO:0000313|EMBL:ADI05097.1, ECO:0000313|Proteomes:UP000000377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BCW-1 {ECO:0000313|EMBL:ADI05097.1,
RC ECO:0000313|Proteomes:UP000000377};
RX PubMed=20581206; DOI=10.1128/JB.00596-10;
RA Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA Xiang W.S.;
RT "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT bingchenggensis.";
RL J. Bacteriol. 192:4526-4527(2010).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP002047; ADI05097.1; -; Genomic_DNA.
DR STRING; 749414.SBI_01976; -.
DR KEGG; sbh:SBI_01976; -.
DR PATRIC; fig|749414.3.peg.2045; -.
DR eggNOG; COG0300; Bacteria.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_222687_0_0_11; -.
DR Proteomes; UP000000377; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 5.
DR CDD; cd00833; PKS; 6.
DR Gene3D; 3.30.70.3290; -; 6.
DR Gene3D; 3.40.47.10; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 6.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 5.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 5.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 6.
DR Pfam; PF16197; KAsynt_C_assoc; 6.
DR Pfam; PF00109; ketoacyl-synt; 6.
DR Pfam; PF02801; Ketoacyl-synt_C; 6.
DR Pfam; PF08659; KR; 5.
DR Pfam; PF21089; PKS_DH_N; 5.
DR Pfam; PF00550; PP-binding; 6.
DR Pfam; PF14765; PS-DH; 5.
DR SMART; SM00827; PKS_AT; 6.
DR SMART; SM00826; PKS_DH; 5.
DR SMART; SM00822; PKS_KR; 5.
DR SMART; SM00825; PKS_KS; 6.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM01294; PKS_PP_betabranch; 5.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 6.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 10.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 6.
DR SUPFAM; SSF53901; Thiolase-like; 6.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00606; KS3_1; 5.
DR PROSITE; PS52004; KS3_2; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000377};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..428
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 968..1043
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1062..1478
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2723..2798
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2815..3231
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4496..4571
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4597..5019
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6251..6326
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6349..6773
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 8023..8098
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 8117..8541
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 9794..9869
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 28..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1482..1507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7325..7380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..959
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7357..7371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 9950 AA; 1035275 MW; 0E35624FADB22C97 CRC64;
MVGLSCRLPS APDPARFWEL LRDGVSAVSE PPPGRRGHAH HENAHHENGD GGPGDGGPGH
RGHGAFLADV DRFDAEFFGI SPREARAMDP QQRLMLELGW EVLEDAGMPP DAVRGSDTGV
FVGVTADDYG TLDRRRGVAG IGHHTLTGLN RSIIANRVSY FLGLRGPSLV VDTGQSSSLV
AVHLACESLR RGESRTALAG GVQLNLTPES TEAAARFGGL SPDGRCFTFD ERANGYVRGE
GGGLVLLKPL ADAVADGDEI YCVIEGGAVN NDGAGDALTT PDQRAQQAVL RAACRRAGAD
PTAVRYVELH GTGTRVGDPV EAAALGAVYG AGRPADEPLL VGSAKTNVGH LEGAAGIVGL
LKVALSLRHG TLPASLNFER PNPRIRFDEW RLDVVTSPRP WPAHNGSVLA GVSSFGMGGT
NCHLVVSDAA SLGRATSAAA GPATDLMAAA DGEGPEPGFV PWLLSGRTPD ALRAQAARLA
AHVTGDGGAA GPDDADGGPE TSPAAIADVG FSLATTRATF DHRAVVLARH RDGALRTLTV
LADGTPGSGA IQGSAPYSAA TTAFLFSGQG SQRAGAGQEL YRRYPVFARA LDDVCSLMDG
HLERPLREVM FAPEGTDDAD LLHRTAYTQP ALFALHVALF RLLESWGTTA DFVAGHSIGA
VAAAHVAGVL SLADACTLVA ARGRLMQALP TGGAMASIQA PEDEVRPLLA GREHEISLAA
VNGPASVVVA GAEDAVEDVV AHFADAGRRT KRLRVSHAFH SPRMDAMLDD FRQVVAGLSL
AGPRIPVVSD LTGELATAEQ LCSAEYWARH ARETVRFADT VRTLRGRGAG AFLELGPDGV
LTGMTRECLD QLPTSAADAE DTQGPIDTPP AVVRTLRPGS DESLTVLTAM AELHVHGVPV
RWDAYFAQRG GRRVALPTYA FQRERHWLDG QPAGQVTEYS PAALPGAPEP VPGEAPAPAE
PAARRPRVDM ARLVRAETAM VLGYAEPERV DTSLTFKQLG FDSTMTVELM SRLRSATGLR
LPDTALFDHP TPDRIAARLA TETSGATGTG ETPPRAPAAP ADEPVVIVGM GCRYPGGVDT
PEALWDLVAS EADAVSAMPA DRGWAAEVLA TQRPGGFLYD ADRFDAALFG ISPREALAMD
PQQRLALEVT WEAVERAGIA PSSLHGSRTG VFVGAMAQDY GPRLHEATGD AEGYVLTGTS
PSVLSGRVAY TLGLRGPALT VDTACSSSLV ALHLAAQSLR SGECSLALAG GVTVMSEPGI
FVEFAKQGGL SEDGRCKAFA EAADGTGWSE GVGMLVLERL SDARRNGHRV LAVLRGSAVN
SDGASNGLTA PSGVSQQQVI GQALAGAGLV PADVDAVEAH GTGTRLGDPI EAQAILATYG
QGRDAGRPLL LGSIKSNIGH TQAAAGVAGV IKMVMAMRQG TLPRTLHVDA PSSHVDWTAG
AVELLTEPMS WPEAERPRRA GVSSFGISGT NAHVIVEQAP HEPPPATAAE LAPPDTTPEA
APRVVPWPVS GRTDAALRAQ LDRLHSFLAD TRAPAPDIGY SLATTRAQLE HRAVLLSTPD
GVVEAARGVA ASAGPLTLLF AGQGAQRIGM GRELAHRFPV FARALDEVCT LLDGELGRPL
REVMFGADAA ALDRTEYAQP ALFALEVALF RLAESWGIVP DLLIGHSIGE IAAAHIAGVL
SLGDACALVA ARGRLMQALP EGGAMVALRA GEDEVEPLLV DHTDRAQLAA VNGPSSVVLS
GDAETVADIA ARFEARGRKA TRLRVSHAFH SPLMAPMLAD FRAAVERLAF QEPRVPILST
VTGELADAAR ISTPDYWVDH VVRPVRFAAA IAAAASAGSR VFLELGPDAT LTALTGDNLA
ELPGVTAVPM LRTDRGEDDE TAVVTAAARL HAHGVPVQWP ALFTGTGARR VELPTYAFQR
ERYWAGRTAG AADVASAGLD RPEHPLLGAV VRLPDTGGLL CTGVLSTTAQ PWLADHVVAG
QVLFPGTGFV ELAVRAGDEA GCGLVRELTL TAPLVLPEHG GIPVQVALGP PDDTDCRTLG
IYSRPDDAPD APWVRHATGV LAPGEPGAPG RVPVPADEGN AADQWAYGRT WPPADAVPVD
LDDFYERRSA AGFDYGPAFR GVRALWQTEE AVLAEVALPG HIAGDAAAFG LHPALLDAAL
HIVSYTGLDD SAGARLPFAW TEVSLHASGA SVLRVRMSRA GDDTVTLTVA DTEGQVVASV
RSLALLPYTP DGGGRGGQPL LRLDWVAVDA APSAEDGQAR RWSVAGPHAW GLADVLRSAG
ETVIDEATAP ADVVLVPVAA PAGAAAEDDT LDAVRAATSA ALDRLQRHLR DADEPENTPA
VVFVTRGAVA TDADASPDLV GAAVWGLVRS AQHESPGRFV LLDLDPDGTD APPTAGSLRA
ALELDEPQLA VREDRLLTLR LTPVRPSEQV AEPRPEAVWD TDGTVLVTGG LSGLGAQVAR
HLADAHGVRH LVLAGRRGRA TEGADDLVAE LARLGAEVSV VACDVSDRAA VARLIGDIPA
AHPLTGVVHA AGVLDDGLVE ALTEERLDTV FRPKAAGAWH LHELTRSHDL TAFTVFSSVF
GVLGNAGQGS YSAANAFLDA LVRRRAAQGL PGLAIAWGPW PQGSGMTSTL TDAEMRRMTR
AGLPPLTAEQ GLAWFDAAPT AGEPAVVAAQ VDRAALRARG TVPAAFRALV PAPVRRGGAG
GAPGAGAGPL AELAGLTGAD LTDAVSRLVR TAVAAVLGHP SAEAVDPSLT FQDLGLDSLT
SVELRNQLTE TTGVRLPTTL IFDYPTPEAV AHFLSARSQG TTATPQVPAA PTVTGDPIVI
VGMACRYPGG VSSPEELWEL TAQGRDGISD FPDDRGWSLP DVSFARVGGF LYDAGDFDAG
FFGISPREAL AIDPQQRLLL ETSWEALERS GMDPLTLKGS ATGVFAGVMY HDYPVAGDGL
PEALRGFVVN GTSGSVASGR VAYTLGLEGP AVTIDTACSS SLVAVHMAAQ ALRSGECSLA
LAGGVTVMAT PETFVDFDRQ GGLASDGRCK SFSDTADGTG WSEGVGMLVL ERLSDARRLG
HEVLAVVRGS AVNQDGASNG LTAPNGPSQQ RVIRQALASA GLSAGDVDVV EAHGTGTALG
DPIEAQALLA TYGQDREADR PLLLGSVKSN IGHTQAAAGA AGIIKMVMAM RRGAVPRTLH
LEVPSSHVDW SAGAVELVVD QRAWPEVGRA RRAGVSSFGI SGTNAHVILE HVPAEPIAPV
VEEPSSPAVV PLMVSGKTDA ALRAQAERLR SYLAERPEAG RADVGLSLAL SRSRFEYRAV
LLTRDRESAL DALAALAAGE STSDVVLGSV APRPGVTAFL FTGQGSQRPG MGRELAGRYP
VFADALDAVI EELDGHLSRP LREILFAEAG TPEAELLDRT EFTQPALFAV EAALFRLLES
WGITPRFVAG HSIGELAAAH AAGVLSLPDA CTLVAARARL MQALPEAGVM VSVQATEEEV
APLLAGREHL IGIAAVNGPE AVVIAGDESA VRDVADEIAA RGRRTKRLSV SHAFHSPLMD
PMLDDFRTVA EGLTYHAPRI PMVSMVTGTP VTGSGTDGDD ETASADYWVR HARAAVRFAD
GLRALEDAGV DTFLEIGPDG VLSAMARDSL SPGTALLPLL RRDRSEELSA ATALARLHVR
GTSPDWAAFL AGNGTGRAAY RVELPTYAFQ HERYWPQATS STAGDITAAG LGSADHPMLG
ASVELADGEG ALFTSRLSLR THPWLAQHAV MGAVLLPGTA LLELAIRAGD EVGCDHVEEL
TLATPLVLPE HGAIQVQLRV GAADEAGRRP VVVSARPEGA AGQEWVRHAD GVLGVRAHTT
APDTAFDAVQ WPPTGAAPLA LEGLYDRLAE DGFGYGPLFQ GLTAAWRRGT AIFAEIALPD
VGDDGTSVAD AEDIDGFGLH PALLDSSLRA VALLDGDIPR TALPFSWENV TLHASGARAL
RIRLAPAGRH TVSLGLADTS GTPVATVGSL ALRPLSAEQL SSAAGAAERD SLFRLDWTAA
TVDHAAPPAD AGPLTVVGPD SLGLAGALEA AGHTVRPYAD LADLIQVVGD EAVAPGVVLI
PLTGAVDAAE AADTVVAAAH RLSAQVLTYL QTWLAEEERL AGSRLVFITR GAAGDPPGAH
DVAAATVWGL VRSAQAEHPD RFVLADLDAR PESAAALPGA LGSAEPQLVI RDGAVHVGRL
ARVPVPGEPG AEWDPEGTVL ITGGTGGLGG ILARHLVTDH QVRHLLLASR RGRAAAGADR
LVDELTALGA QVTVASCDMA DRDALAELVA GVERDHPLTA VVHTAGVLDD GVIETLTPQR
MAAVLRPKAD AAWHLHELTR HLDLTAFITF SSVVGTFGGA GQANYAAGNA FLDALAEHRR
TAGLPAVSLA WGPWTQAGGM TSTLTEADMR RLAREGMPAL PAERGVALFD AALATPDAVL
LPVPLDLPAL RARGEIPPLL RGLIRTPLRR SAATGSGTSA SLAQRLSALP RAERSEAALD
LVRTHVALVL GHATADVVAP TRAFQELGFD SLTAVELRNR LGAASGLRLP ATVVFDYPTA
EALAGYLLDE LLGREATDTA DAGEAGNTAH ALLPVADDPV VVVGMPCRYP GGVRTPEDLW
RLVDGSQDAV SGFPDNRGWD LEALYDPDPD HAGTSYTRQG GFLHDAGEFD AAFFGLSPRE
ALATDAQQRL LLETSWEAFE RAGIDPVSLR GSRTGVFAGV MYNDYGTLLR GAEFEGYQTN
GSAGSVVSGR VSYTLGLEGP AVTVDTACSS SLVAMHLAAQ ALRSGECSLA LAGGVTVMST
PASFVEFSRQ RGLSPDGRCK AFSESADGVG WSEGVGVVVL ERLSDARRNG HDVLAVVRGS
AVNQDGASNG LTAPNGPSQQ RVIRQALASA ALSAADVDVV EAHGTGTTLG DPIEAQALLA
TYGQDRERPL LLGSVKSNIG HTQAAAGAAG IIKMVMAMRQ GTVPRTLHLE APSSHVDWSA
GAVELVVEQR AWPEVGRARR AGVSSFGISG TNAHVILEHV SAEPTALAAE EPSSPAVVPL
MVSGKTDAAL RAQAERLRSH LAEWPEAGRA DVALSLALSR SRFEHRAVLL TRDRESALDG
LAALAAGEPA ADVVLGAAAL RPGATAFLFT GQGSQRPGMG RELAGRYPVF ADALDTAIEE
LDGQLSRRLR EILYAEVGTP EAELLDRTEF TQPALFAVEV ALFRLLESWA IVPDYLVGHS
VGEIAAAHVA GVLSLADACA LVVARGRLMQ GLPAGGAMVA VQAAEDEVAP LLSDGVSIAA
VNGPGSVVVS GAEREVLELA ERFAAQGRKT SRLRVSHAFH SPLMDPMLDE FRTVAEGLSY
QPPAIPVVSN VTGGPATEEQ LCSADYWVEH VRATVRFSDA IAALGDTGVR RFLEVGPDAS
LLALAAETAS DDAVLVPVLR KDRGEEHAVT AALAQLYVDG VEADWAALFP GARRVDLPTY
AFQRRWFWPR TEPSVEDAVA FGLTSAEHPL LNGAVELAGS EGRLFTGRLS LPLRSHAWLA
DHRVSGRVLV PGTALLELAV RAGDEVGCDR VEELTLAAPL TLPEQGAVQV QLVVGDPDEA
GRRPVSVYSR PEGRSEEWVL HAGGVLAEAG RADHVGGWPV WPPEGAERVD LTGCYERFAE
FGFDYGPLFQ GLRSVWRRGT DVFAEVALPD GPEADAAAFG LHPALLDAAL HAASWAGTEV
RPGVLPFSWS GVCLYGAGAS ALRVRLSSAG PDTLSLEATD PSGRPVLSVE SLALRAMSAE
TTGDTGGAVA DSLFRLDWTP VRASTVPPAS VAVVGPDDGG LVEGLRTTGP AVVGCEDLAA
LAAGEDAPPA VVLMPVSRPA GDVVGATHEV TSRILGVLQA WLTDERWTRS RLVFMTRGAT
TGEDLAAASV WGLVRVAQSE HPDRFALLDL DGGQPSAAAV AQALGSDEPQ TAVRDGAVLV
GRLVRTPAVR TPAVRTSAVG EETAGVEWDP EATVLITGGT GGLGGVLARH LVVEYGVRHL
LLASRSGGAA NGAAELVTEL TDHGADVRAV ACDVADRDAV AALLADVPAD RPVRAVVHTA
GVLDDGVLEA LTPERLAKVA RPKVDAAWAL HEATRELDLT AFVTFSSVAG TFGSAGQGNY
AAANAFLDAL AEHRRAAGLP AVSLAWGPWS RAGGMTSGLT DADMERMTRA GTPPLSVEEG
VALFDAALAT GEAAVVPVRL DLPALRARGE IPPLLRSLIR TRTRRHTLPS SGEAATLVGR
LSGLTDTDRR EALVDLVRVQ VALVLGHTGS GEVGVSRSFQ DLGFDSLTAV ELRNRLNTAT
GLRLPATLVF DYPTVVALSE HLHRELFGVR TDGPAPDQAR DQALPVVSDD PVVVVGMACR
YPGGVRSPED LWRLVVGGQD AISGFPSDRG WDLEALYDPD PDHFGTSYTR EGGFLQDAAE
FDAAFFGLSP REALATDAQQ RLLLETSWEA FERAGIDPVS LRGSRTGVFA GVMYNDYGTL
LQGPEFEGYQ ANGSAGSVVS GRVSYTLGLE GPAVTVDTAC SSSLVSMHLA AQALRAGECS
LALAGGVTVM STPVAFVEFS RQRGLSPDGR CKAFSESADG VGWSEGVGVV VLERLSDARR
NGHEVLAVMR GSAINQDGAS NGLTAPNGPS QQRVIRQALA SGGLSASDVD VVEAHGTGTR
LGDPIEAQAL LATYGQERKA DRPLLLGSVK SNIGHTQAAA GVAGVIKMVM AMRHGLLPRT
LHVDAPSSEV DWEDGAVELL TQAVEWPGTG HPRRAGVSSF GISGTNAHLI VEQPGLSDPV
DGGLEEPSDG AGVVPWVVSG ASPAALRAQA GRLLSHVRAD GELGLRDVGF SLATGRSVFE
HRAVVLAEDL EGVARGVAAL AAGEADGGVV EGSVSDQGRK AFLFTGQGAQ RLGMGRELYE
RFPVFAGAWD EVVAGLDPLL GVALRDVVWG EEEGLLNRTE FAQPALFAVE VALFRLLESW
GIVPDYLVGH SVGEIAAAHV AGVLSLADAC ALVVARGRLM QGLPVGGAMV AVQAAEDEVV
PLLSDGVSIA AGNGPGSVGV SGAEREVLEL AERFAAQGRK TSRLRVSHAF HSPLMDPMLD
EFRTVAEGIS YQPPAIPVVS NVTGGLAVEA QLCSADYWVA HVRQAVRFAD GVRTLADAGV
TVFVELGPDG VLSALAQESA PEEAALVPVL RKDQGEERSA LTALARLHVR GVEVDWSPLF
AGARRVALPT YAFQHERFWP KGTATRAGDV RAAGLGAADH PLLGAAVELA GAGGHLFTSL
LSARSHPWLV DHRVMGRLVV PGTALVELAL RAGDQVGCDR VDELTLTAPL VLPEQGSVQL
QLTVGEPDET GSRPVSVHSR PEGAEDTPWL RHATGTLTAA ASPSSTELGD ATPETGVWPP
TGAVPLDLDG FYERRAAEGF GYGPAFQGLR AAWRLGGELL AEVDLPERME ADAATFGLHP
ALLDAALHAA VLDDSDSGSD TDTSAVPFSW SGVSLRAVGA SSVRVRLSRR ADGALSIALA
DPSGAPVATV DSLVVAELPA EHGDGGDGAP DIARTSMFRL DWVATPAAAP VGERLAVVGP
DPLGLVALIE EGGATVETHA DLASLAAASE AAAPGIVLVP VVGGDSGSPV VESVRTMTTS
VLGQLRTWLA EDRWADCRLV FVTRGATAAG DLAAAPVWGL VRSAQTEHPG RFGLIDLDLD
LDPQPGATAD RALDGARTPG ALLLEALASA EPQLALRDGA IRAARLARVP APDGTSPAWD
SEGTVLITGG TGGLGRLVAR HLVTECGIRH LMLLSRSGPA ADGAGDLVAE LTAHGADVTV
TACDIADRDG LAEVLAGVPE AHPLRGVVHT AGVLDDGVVE ALSPGRMESV LRPKADAAWH
LHELTRDMDL SVFALFSSVA GVFGGAGQAN YAAGNAFLDA LAEHRRTAGL PAVSLAWGPW
EPAGGMTSAL SEADLRRMAR SGMHALSAEQ GVALFDAALA SGEAAVVPVR LDLPALRNQD
EIPWLLRGLV RAKARRAAVV GSGAATSLIR RLSALTHREE RRDALLSLVR GQVALVLGHA
GAESVEPSRS FQDLGFDSLT AVELRNRLNS ATGFRLPATL VFDYPRPTTL ADYLLDELFG
VETEMPAPTH TLPATSDDPV VVVGMACRYP GGVRTPEDLW RVVFEGVDVV SGFPTDRGWD
LEALYDPDPD HLGTSYTREG GFLQDVGEFD AAFFGLSPRE ALATDAQQRL LLETSWEAFE
RAGIDPVSLR GSRTGVFAGV MYNDYADLLG GGEFEGYQGN GSAASMASGR VSYTLGFEGP
AVTVDTACSS SLVSMHLAAQ ALRAGECSLA LAGGVTVMST PVAFVEFSRQ RGLSPDGRCK
AFSESADGVG WSEGVGVVVL ERLSDARRNG HEVLAVMRGS AINQDGASNG LTAPNGPSQQ
RVIRQALASG GLSASDVDVV EAHGTGTRLG DPIEAQALLA TYGQERKADR PLLLGSVKSN
IGHTQAAAGV AGVIKMVMAM RHGVLPGTLH VDAPSSHVDW EAGAVELLTG PAEWPSADRV
RRAGVSSFGI SGTNVHLIVE QPEPSDAVGG ASEELSEGSG LVPWVVSGAS SAALRAQAGQ
LLSHVRAGGE LGLRDVGFSL ATGRSVFEHR AVVLAEDLEG VARGVAALAA DESHVDVIEG
SATSEGRTAF LFAGQGAQRL GMGRELCERF PVFAGAWDEA VAELDPLLGV SLRDVVWGDD
EGLLNRTEFA QPALFAVEVA LFRLVESWGI APDYLVGHSV GEIAAAHVAR ALSLADACAL
VVARGRLMQG LPVGGAMVAV QAAEDEVVPL LSSEVSIAAV NGPGSVVVSG AEETVLEIAE
RFAAQGRKTS RLRVSHAFHS PLMDPILDEF RTVAEGLSYQ PPAIPAVSTL TGGPAKSTDL
CSADYWVEHV RSTVRFSDAM AVLGDAGVRR FLEVGPDGSL SALAAESLAD EPLLVPVVRK
GRGEERSALT AMARLFANGA EVCWAALFPG ARRVPLPTYA FQHERFWPTG TVSRAGDVRA
AGLGDAHHPL LGASVELADS QRALFTSRLS VGSHAWLADH VVMGRVVVPG TALLELTLRA
ADEVGCDRVE ELTLAAPLVL PEQGAVQLQL AVHEADDSGR RPVSVHSRPE GTAREWTLHA
SGVLTEGERT ATATPLGVWP PESAEHIDVG DCYDRFADIG FDYGPLFQGL RAAWRRGDEL
FAEVALPERG EADAAAYGLH PALLDAVLHT ALLAGLDKAD GGGGGDDGAA GTGAMASLPF
SWEGVSLHAS GASALRVRLS PAGDNAMSIT LADTAGGPVG SIDSLVVRSM SADQLGAAAD
TSEGDALFRV DWTPLAPAVD TPDAVTAVVL GSERSWLAEA LRAAGTPVEV CAEIAGVTSP
PTGADVPEVV LVPVGDGTPE DPVIPEDPAF PEDPVRSAHQ AVSWALHLAQ SWLADEGAAA
SCLVFVTRGA TTGEDLAAAS VWGLVRSAQT EHPGRFGLVN LDDTDASVAA LRKALASGEP
QLDVRAGAIT VPRLVRASTS VADPDTSAVV WDPEGTVLVT GGTGGLGREV ARHLVTEHGV
RNLILASRSG PNADGVGELV AELARHGADA QAVACDVADR DAVAALLAGV APERPVRAVV
HTAGVLDDGV LESLSPERVA AVLRPKADAA WVLHEATREL DLTAFVLFSS VAGVFGGAGQ
ANYAAGNAFL DALAEHRRTA GLPAVALVWG PWTQTEGMTS TLAEADLARL ARSGMPPLSI
EEGLALFDAA LATGAAAVVP VRLDLPAWRA QGEVPALLRG LIRTRTRRAA GAGVGTRASL
ADRLIGLGDT ERAEAVRELV SAQAADVLGH AGADAIEPTR EFKTLGFDSL TAIELRNRLN
AATGLRLPAT LIFDYPTPDA LADHIRTQLV PEDAGPMSIL AELDRLELAF AQVPVDPELH
ERVAGRLEVL RSRWGALQGD PDQKADHEFD FDAATDSEVF EMLDNELGLS
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