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Database: UniProt/TrEMBL
Entry: D7BYQ3_STRBB
LinkDB: D7BYQ3_STRBB
Original site: D7BYQ3_STRBB 
ID   D7BYQ3_STRBB            Unreviewed;       739 AA.
AC   D7BYQ3;
DT   10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT   10-AUG-2010, sequence version 1.
DT   07-JUN-2017, entry version 43.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ADI05612.1};
GN   OrderedLocusNames=SBI_02491 {ECO:0000313|EMBL:ADI05612.1};
OS   Streptomyces bingchenggensis (strain BCW-1).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=749414 {ECO:0000313|EMBL:ADI05612.1, ECO:0000313|Proteomes:UP000000377};
RN   [1] {ECO:0000313|EMBL:ADI05612.1, ECO:0000313|Proteomes:UP000000377}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCW-1 {ECO:0000313|EMBL:ADI05612.1,
RC   ECO:0000313|Proteomes:UP000000377};
RX   PubMed=20581206; DOI=10.1128/JB.00596-10;
RA   Wang X.J., Yan Y.J., Zhang B., An J., Wang J.J., Tian J., Jiang L.,
RA   Chen Y.H., Huang S.X., Yin M., Zhang J., Gao A.L., Liu C.X., Zhu Z.X.,
RA   Xiang W.S.;
RT   "Genome sequence of the milbemycin-producing bacterium Streptomyces
RT   bingchenggensis.";
RL   J. Bacteriol. 192:4526-4527(2010).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002047; ADI05612.1; -; Genomic_DNA.
DR   RefSeq; WP_014175089.1; NC_016582.1.
DR   STRING; 749414.SBI_02491; -.
DR   EnsemblBacteria; ADI05612; ADI05612; SBI_02491.
DR   KEGG; sbh:SBI_02491; -.
DR   PATRIC; fig|749414.3.peg.2579; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; SBIN749414:GHKA-2502-MONOMER; -.
DR   Proteomes; UP000000377; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000377};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000377}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  79388 MW;  2C4D0EFC4B557DBD CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVQAYA STAGVTVETR DISLAGRLIA VFPEYLEEGL
     RIPDALAELG ELAKTPEANI IKLPNISASI PQLKAAVAEL QQQGYALPDY PDDPKTDEER
     EIRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKTHPH RMGAWSADSK TNVATMGVDD
     FRSTEKSAVI SEAGSLRIEL AGDDGSTTVL RESVPVLAGE VVDASVMRVA ALREFLTAQV
     ARAKAEDVLF SLHLKATMMK VSDPIVFGHG VRAFFPKTFA AYGEVFAAAG LTPNDGLGGI
     LKGVESLPEG AKIKESFEAE LAEGPRLAMV DSDRGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEAD TLAVLPDSSY AGVYQAVLDD CRANGALDPA TIGSVPNVGL MAQKAEEYGS
     HDKTFEIPAT GTVRVLDEAG NVVLEQVVGA GDIFRMCQTK DLPIRDWVKL AVTRARATGD
     PAVFWLDENR AHDAQLIEKV KAYLPEHDTE GLRIEIMAPV EATKFSLERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALVP SLEQYAKTTG NARATVLADT LDRATATFLN EDKSPSRRVG GIDNRGSHFY
     LALYWAQELA KQTDDADLAK AFAPLAETLA AQEQTIVDEL IAVQGEPADI GGYYQPDPAK
     AAAVMRPSAT FNEALATLG
//
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