ID D7D332_GEOSC Unreviewed; 307 AA.
AC D7D332;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 01-MAY-2013, entry version 25.
DE RecName: Full=2-dehydropantoate 2-reductase;
DE EC=1.1.1.169;
GN OrderedLocusNames=GC56T3_2948;
OS Geobacillus sp. (strain C56-T3).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=691437;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C56-T3;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Kourtz L., Brumm P., Mead D.,
RA Woyke T.;
RT "Complete sequence of Geobacillus sp. C56-T3.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate
CC into pantoic acid (By similarity).
CC -!- CATALYTIC ACTIVITY: (R)-pantoate + NADP(+) = 2-dehydropantoate +
CC NADPH.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
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DR EMBL; CP002050; ADI27889.1; -; Genomic_DNA.
DR RefSeq; YP_003672466.1; NC_014206.1.
DR ProteinModelPortal; D7D332; -.
DR EnsemblBacteria; ADI27889; ADI27889; GC56T3_2948.
DR GeneID; 9238046; -.
DR KEGG; gct:GC56T3_2948; -.
DR PATRIC; 38173130; VBIGeoSp154431_3200.
DR HOGENOM; HOG000050222; -.
DR KO; K00077; -.
DR BioCyc; GSP691437:GI2V-3040-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR013752; ApbA_C.
DR InterPro; IPR013332; ApbA_N.
DR InterPro; IPR013328; DH_multihelical.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR TIGRFAMs; TIGR00745; apbA_panE; 1.
PE 3: Inferred from homology;
KW Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis.
SQ SEQUENCE 307 AA; 34016 MW; 976F3B6D6628FA6B CRC64;
MRILFVGAGA VGGYFGGRLL EKGVDVTFLV RERRKQELEK YGLVIHSIHG DAVLAPKLLV
AGESAEPFDL VVFSNKAYHL DGAIADAKPY VGEATMILPL LNGMAHMEAL WKAFGRENVL
GGLCFIETTL NERGEIIQTS PAHEMRFGEW PNGRSERTEV LASLFAGANA CFRLSEQIAA
DMWNKYLFIA TMSGVTTLFR APIGPIRSGE YGSVIIDRLF REIKTIIQAH GAPLTDEMAE
RQRTQLEQIA PTMKSSMQRD MEKGQLIEAD HLQGYLLALA KRHGIHAPML EAVYHNLKIY
EASRATS
//
