ID D7EB19_METEZ Unreviewed; 225 AA.
AC D7EB19;
DT 10-AUG-2010, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 1.
DT 01-MAY-2013, entry version 23.
DE RecName: Full=Triosephosphate isomerase;
DE Short=TIM;
DE EC=5.3.1.1;
DE AltName: Full=Triose-phosphate isomerase;
GN Name=tpiA; OrderedLocusNames=Metev_1697;
OS Methanohalobium evestigatum (strain DSM 3721 / OCM 161 / Z-7303).
OC Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC Methanosarcinaceae; Methanohalobium.
OX NCBI_TaxID=644295;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3721 / OCM 161 / Z-7303;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Sieprawska-Lupa M.,
RA Whitman W.B., Anderson I., Woyke T.;
RT "Complete sequence chromosome of Methanohalobium evestigatum Z-7303.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone
CC phosphate.
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate from glycerone phosphate: step 1/1.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
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DR EMBL; CP002069; ADI74536.1; -; Genomic_DNA.
DR RefSeq; YP_003727332.1; NC_014253.1.
DR ProteinModelPortal; D7EB19; -.
DR EnsemblBacteria; ADI74536; ADI74536; Metev_1697.
DR GeneID; 9347341; -.
DR KEGG; mev:Metev_1697; -.
DR HOGENOM; HOG000223030; -.
DR KO; K01803; -.
DR OMA; IPVYAQH; -.
DR BioCyc; MEVE644295:GHG3-1854-MONOMER; -.
DR UniPathway; UPA00109; UER00189.
DR UniPathway; UPA00138; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:HAMAP.
DR GO; GO:0006094; P:gluconeogenesis; IEA:HAMAP.
DR GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:HAMAP.
DR Gene3D; 3.20.20.70; -; 1.
DR HAMAP; MF_00147_A; TIM_A; 1; -.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000652; Triosephosphate_isomerase.
DR InterPro; IPR022891; Triosephosphate_isomerase_arc.
DR PANTHER; PTHR21139; PTHR21139; 1.
DR Pfam; PF00121; TIM; 1.
DR SUPFAM; SSF51351; Triophos_ismrse; 1.
DR TIGRFAMs; TIGR00419; tim; 1.
DR PROSITE; PS51440; TIM_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase;
KW Pentose shunt.
FT ACT_SITE 96 96 Electrophile (By similarity).
FT ACT_SITE 144 144 Proton acceptor (By similarity).
FT BINDING 12 12 Substrate (By similarity).
FT BINDING 14 14 Substrate (By similarity).
SQ SEQUENCE 225 AA; 23080 MW; 85A8DCF078DBBEE6 CRC64;
MNSSKSPLIV VNLKTYLQGT GEKAVTIAKA CKNVSEKYNV DIGVSPQFCD IYQVASQVDV
PVYSQHIDGI DGGSHTGQIL AQCVKDAGAI GTLVNHSERR LTLADIDSSV KAAGKAGLST
IVCTNNVNTS ASAASLGPDY IAIEPPELIG TGVPVSSADP QVVKGSVDAV KNVNEDVKVL
CGAGISKGED LQAALELGSA GVLLASGVVK AEDPEKALEH LVSQI
//
