ID D8IVA3_HERSS Unreviewed; 9160 AA.
AC D8IVA3;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Non-ribosomal peptide synthetase protein {ECO:0000313|EMBL:ADJ63842.1};
GN OrderedLocusNames=Hsero_2343 {ECO:0000313|EMBL:ADJ63842.1};
OS Herbaspirillum seropedicae (strain SmR1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Herbaspirillum.
OX NCBI_TaxID=757424 {ECO:0000313|EMBL:ADJ63842.1, ECO:0000313|Proteomes:UP000000329};
RN [1] {ECO:0000313|EMBL:ADJ63842.1, ECO:0000313|Proteomes:UP000000329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SmR1 {ECO:0000313|EMBL:ADJ63842.1,
RC ECO:0000313|Proteomes:UP000000329};
RA Pedrosa F.O., Monteiro R.A., Wassem R., Cruz L.M., Ayub R.A., Colauto N.B.,
RA Fernandez M.A., Fungaro M.H.P., Grisard E.C., Hungria M., Madeira H.M.F.,
RA Nodari R.O., Osaku C.A., Petzl-Erler M.L., Terenzi H., Vieira L.G.E.,
RA Almeida M.I.M., Alves L.R., Arantes O.M.N., Balsanelli E., Barcellos F.G.,
RA Baura V.A., Binde D.R., Campo R.J., Chubatsu L.S., Chueire L.M.O.,
RA Ciferri R.R., Correa L.C., da Conceicao Silva J.L., Dabul A.N.G.,
RA Dambros B.P., Faoro H., Favetti A., Friedermann G., Furlaneto M.C.,
RA Gasques L.S., Gimenes C.C.T., Gioppo N.M.R., Glienke-Blanco C., Godoy L.P.,
RA Guerra M.P., Karp S., Kava-Cordeiro V., Margarido V.P., Mathioni S.M.,
RA Menck-Soares M.A., Murace N.K., Nicolas M.F., Oliveira C.E.C.,
RA Pagnan N.A.B., Pamphile J.A., Patussi E.V., Pereira L.F.P.,
RA Pereira-Ferrari L., Pinto F.G.S., Precoma C., Prioli A.J., Prioli S.M.A.P.,
RA Raittz R.T., Ramos H.J.O., Ribeiro E.M.S.F., Rigo L.U., Rocha C.L.M.S.C.,
RA Rocha S.N., Santos K., Satori D., Silva A.G., Simao R.C.G., Soares M.A.M.,
RA Souza E.M., Steffens M.B.R., Steindel M., Tadra-Sfeir M.Z., Takahashi E.K.,
RA Torres R.A., Valle J.S., Vernal J.I., Vilas-Boas L.A., Watanabe M.A.E.,
RA Weiss V.A., Yates M.A., Souza E.M.;
RT "The genome of Herbaspirillum seropedicae SmR1, an endophytic, nitrogen-
RT fixing, plant-growth promoting beta-Proteobacteria.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP002039; ADJ63842.1; -; Genomic_DNA.
DR RefSeq; WP_013234321.1; NC_014323.1.
DR STRING; 757424.Hsero_2343; -.
DR KEGG; hse:Hsero_2343; -.
DR eggNOG; COG0318; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG2175; Bacteria.
DR HOGENOM; CLU_222728_0_0_4; -.
DR OrthoDB; 8824838at2; -.
DR Proteomes; UP000000329; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd17646; A_NRPS_AB3403-like; 2.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd17649; A_NRPS_PvdJ-like; 1.
DR CDD; cd19543; DCL_NRPS; 3.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 7.
DR Gene3D; 3.40.50.980; -; 10.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 9.
DR Gene3D; 3.60.130.10; Clavaminate synthase-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 9.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR042098; TauD-like_sf.
DR InterPro; IPR003819; TauD/TfdA-like.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 6.
DR NCBIfam; TIGR01720; NRPS-para261; 2.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 7.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 8.
DR Pfam; PF00550; PP-binding; 7.
DR Pfam; PF02668; TauD; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 7.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 7.
DR SUPFAM; SSF47336; ACP-like; 7.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 18.
DR PROSITE; PS00455; AMP_BINDING; 7.
DR PROSITE; PS50075; CARRIER; 7.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 6.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000329}.
FT DOMAIN 597..672
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1664..1738
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3155..3234
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5068..5143
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6180..6254
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 7703..7777
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 8788..8865
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 3731..3756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3731..3753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 9160 AA; 993755 MW; 17A24DED00E76156 CRC64;
MNQAASPTLP FDPARHFFAD NFVSQFRAIA AEATETGAEA RTLVVADASG ERRFSFAQLD
LRARAYAAAF QQRCPRGARV LLVLENDEHY VQAFLGCLYA GMVAVPVFPP ESVRPQHLKR
LAGIAADAQA ACVVLPEPLR QTCAQAALFG AAELLAAEQV ADADAVHWRE HTPQPQDIAF
LQYTSGSTSA PKGVMVSHGN LMANEAAISA CMRVREDDIF VTWLPLYHDM GLIGGLLQGL
VRGLKTVLCS PRYFLERPLR WLELVARHRG TVSGGPDFAY RLCVERIKPA QLPGVDLSSW
RVAFCGAEPL RADTFPAFIE RFSVAGFSAD AAYPCYGLAE ATLIVSGGPP HGAHATAFHT
AELAAGRAVE GGPDDTRLVA CGDIAPHHEV RIIEDGRVQQ DGAVGEIEVC GPSVTQGYWQ
RPQESAAAFV ERDGRRWLRT GDLGFLRDGQ LYIAGRRKDL IIVRGQNVYP QDIERAVEDQ
VEAVRKGRVA AFAVNTGDGE GIGVAAEISR GMQKLAAPGA IASAIAEAVA QASLEAPQVV
ILLNPGGLPK TSSGKLQRSA CRSGWRNGEL DAWAIVEEGE LKAGPSDAQG GELLAEPPQG
DIETALAAIW QSALKRAIAG RQADFFRSGG SSLAAMQVVA AVVDRWQVEF TPAMLFAAPT
LAASAAQIAA LLEAGAQAAP LPACVDGQSE FPLTQAQQGL WLTWQLQPDS AAYNLAGVLD
LRGELQVEAL EDALCDLAAR HAALRTLFPL RDGTPVQQVL DIDEARPMLL RSDLRRQPAD
KRAQAAASAL QRFHAQAFRL DSETPLRAML VQLEPHHFRL GLCIHHIAAD GWSLGIILDE
LTAAYEARCA GAAPSWPALE LQPGDYAVWQ RQRSQPGSPE FQRQLDYWRA RLEGAPALLP
LPTDRPRQAG AHGGEGQHRW RLSAALSTAL RKLAASQGVT LYGAVLALFT LALQRLSGQS
DLCVGAPLAD RRRRQTQALV AYLINVQVVR TRIDERSDFL ALMRQVQQAV QEAQAHQDLP
LDALMSALQP ERVAGANPLF QVKCTQQQAI ATVRRMGGLD MRVELQANAE SHFDLSLDFT
DADEGIDILL AYAPALFDAE TVAGFAGLLQ ALAQQVVAAP ALALADLQAF PPVSAADQVL
QPAEDVAACW RRQALAQPDA VALRCGAQFI STSSCCNGSM RWRSAWHAAG AGPESRVALY
AGRDIDFVCG MLAVLDTGAA YVPLDPQLPA ERLAWQLQDS GARWVLHEGQ SAPAWLAQAG
VPLLSLEAAG TAPASPWTPF PVHPAQAAYL IYTSGSTGRP KGVLVTRGGL ANYVAAVLEK
LALPAAARSM AMISTVAADL GHTTLYGALC SGRQLHLITH DLAFDPDGFA AYLHEHAVDV
LKIVPSHLQA LLHAARPEQV LPRHTLVLGG EATGWPLLER IAALQPACRV LNHYGPSETT
VGVLVQEAAS ASRRAAVLPV GSALVGVQAW VLDRQLRRAP VGAVGELYLG GAGLARGYHG
RAALTAERFV AHPFASGQRL YRSGDRARYL GDGSIEFLGR IDDQVKIRGH RVEPGEVRQQ
LLRLAGVVDA AVLALPAADD AQRLQLHGFI VCAAGAVADP AGWRATLAAD LPDYLLPTLT
PVPALPLTAN GKLDRQALAG LMAGAMAAPQ QQVPQVQQAH QAGAPQGELE HKLAAIWAEV
LKLPQVGRED NFFELGGDSI LTLKIVARAR KEGLRIAPKA MMEKQTVAAI VAAGAVQGLL
AATPAPAVVA APADIPLTPV QHWFFEQGFA TPQHWNQSVL LNAPGLDADV LRRALALLAQ
RHESLRLRFV QEGGQWRQRR GPALLPLEII DGDEPGAIAA AGELVQRSLD LAQGPLMAAA
WIRLDAQGKQ GRLLLAGHHL VVDGVSWRVL LDDLAGLYHT LQQGGTPAEL PPATDLYTWS
QALRAHAQRP AVTDQLAYWR SVVDTPEPPL ADATANLAGR AADAGFVLDA DVTARLLALG
AHADPAVRVA PQDLLLAVLA RVLCDWSGRD SLLFELEGHG REDIPGGLDV SRATGWFTAL
YPVRLAPGAT STSIPSALEA VRAQLRAVPA NGLGYGLLRY LSGQGQELAQ GAQPQITFNY
LGHFDHRIEP AGWTLADEYA GAQRAADSRR RCLFEAIARV QQGRLQWQWT YCKDLHAAAE
MRALQERLRT ELMRWIEALE ARAGSDAAYA LSPMQAGMFF HSSMNAGDGA YINQLRLDLA
GVDEARLEAV WREAVRRHPI LRTGFRQQGD APEQWVAQPV LHWRVLDLSG QPPQQQAQQA
QLEQLEQLEQ LEQIAAAELA RGFDLAQPGL MRLVLAKMGE GRHHLIWTRH HLLLDGWSSA
QLFAEIVRAY AGEEIAAPTL AYRHYIDWLQ ARDGAAARDF WRAQLQHLEE PTLLAGALPR
PREDASGHAE HLAAISPAQW QALCQAAKAM RITPGTLLQG AWALVLQRCC GQSAVAFGVT
VVDRPAELEG IESTLGLFIN TLPLAVRLHA AQDCSDWLRA LLHQNLAMRE FAHAPLYEIQ
RWSGRAGQAL FDSILVLENY PMDEAIGRAA DYGLHLSGLR LHEQTSYPLT VVATVQDGLS
LRLGYDRSRF GAYQVAQLAD WLAQALVTLT TGGARLGDCA LGSATQRQQA LGWSLNGQRF
DGQEPVHRLF EQQASRRPDA IALQADGAHW TYGQLNAAAN ALARRLQAAG VGPDTVVALL
AERSAAMVTA LLAVLKAGGA YLPLDPDYPA ERLAWMLEDA RPVCLLSHRG LHRRLALPDT
LLLELEDQLP GSQRGDEPQY NPQHNPQPPL HGEHLAYVIY TSGSTGRPKG AGNSHRALYN
RLRWMQQAYA LQEGDAVLQK TPFGFDVSVW EFLWPLMTGA RLVMAPPGAH RDPAELAALI
REHGVSTLHF VPSMLQAFLA SGQAAACTSL RQVICSGEAL PAEARDQFFA LLPQAALHNL
YGPTEAAIDV THWTCQHGDR GPVPIGQPIS GLRAVVLDAD LNVLPCGVAG ELYLGGIGLA
RGYLGRPGLT AERFVASPFG QGERLYRTGD LVRWREDGQI DYLGRLDHQV KIRGLRIELG
EIEAQLLALD EVEEAVVVAH EHGAGPVLAG YVASRRWQRQ DAATLKQALA ARLPDYMVPA
VLTLLPTLPL NANGKIDRKA LPAPRLHSED FAYAAPQGQV EQRLAQIWQA LLGLERVGRF
DHFFELGGHS LLAASLVARL RYQGEAGVGV ALPLRLVFAY PRLHEMAACI EARPPLPPSS
WRLHLRRCCN LASGAPRRCC RRPSIGCGWW TACQARPMRP PTTMSAALML EGVVDAVLLE
QALRLLVARH DILRTGFGED ADGNPVATLH PFDFSLEQHD LAALPPPQRD LQLDRLRRSH
AAARFALRQP PLLRAALVRL ASQQQVLLLA IHHIVADGWS VALMMEEIAA AYSALQEGRS
YAPPPLPLQY ADYAAWQVAG AGSRMLEDSI AWWRDALAGV PATPYLPSTR PRPARATYAG
QRLRMHLPAH LRSGVQALAR REGVTAYAVL LASFAWLLHQ RSGAGDFVVG TDVAGRSHPD
LERLVGFFVN VLPLRLRPQT LAPRASFVAW LRHCADVAVN AFDHQEPGFD RIVEAAGVPR
ERRWNPLVQV LFVLQNTPRA ALALPGVRAE LLEPLENWSK FDLALFVEDH AGAGDAADGP
GWRADWVYAD ALFDAATVAA LGRDWQRLLE QVLASPWTPL DAALPSSPSD TKAEVPSQVL
LDEITDMTLT SSSAPAAPAG MQQPPSSTSC AKLKGSPAIA AETPRAQVKT SFLQAGREFP
LVIEPAAAGL DMAEWARRER GYIADMLCKH GGVLFRNFGL RTPADFESFA EAIEPELYGG
YGDLPKNEGG KNTYRSTPYP EKEMILFHNE SAHMERWPRK QWFFCELPSP VGGATPIVDC
REVYRRLPAE LAQRFEQKQL LYIRTFTERL DVSWRDFFKT DDRRAVEARL QAAGTQYRWL
AGDELQTRTL CPAVITHPQT GEKVFFNQVQ LHHIACLDPS VRRDLLAMVG MERMPRHVTY
GDGSEIDEQT MALVGQLYEQ CAVRFTWQQG DVVMLDNMIA AHARDPYEGP RKIVVAMGAM
FERKDLLTPA YGVSSIEEGV ASHVSSITLT EGRGEPAPRL LPENPMHPQE QIPSDDVGFP
LTAAQRSLLQ QAAPALHLRL RLPAALDAAR LTLLLERLAR RHQILRCQLR QVPGYRELRL
VDGPPTIRLE GIAHEDENAI AAWRAQAFGQ PQTALWRAAL LEHAGHGQGR ELWLACSPLV
ADYRSLATLA GELMQPEHIV AEEVLQFGAF SDWLDDLVSG ADNRDAAAAG LAYWQAQAQP
AGEAAPWPAS RRNGLATAAP RIELFECALD APLAQALPSS PAAAAERLHA VWLALLARLS
QAFGEDGPRT LASGWLHDCR TDEHLQDMLE GAVGRFERVL PLRLNLGPQA GLRQWQAQLA
QALQQHREQQ EYLPEGAALP LLFGWRDEAA QPAGWATLEL PGPPPGAELT LLALRRPEGW
RLAWHFDTQH YGRQEIAVLA GQYRQLLARA LAVPEQPLLT LPLHGEALAA ATLGQTESCL
PTLTVAQMIA HRAAAQPQSP ALAAGGAVLD YAGLERRVEH LAHALRSLGV APGDIVALQL
PRCAELVLAL LATWRCGAAY LPLDTDSPVA RRQQILQAAK VHLLVMEAGQ SAEGLPADCT
AVAWDELANS PVQASAPLPG SRMDATAYVL FTSGSTGAPK GVLIGHAQLA AYVQGVTQAL
RLDACRHWAL TGTVAADLGN TALFGALANG ACLHVASAED MRDGERFAKF LRQHGIDALK
IVPSHLDALL ETPAPYLPAT LVLGGEATAP AQLARIRALA PQCRVFNHYG PTECTVGVLV
HRAATEAEAE AEADPGASLP LTEALPHAYV RVLDAQLRPT PAGAIGQLWL GGAQLARGYL
DAQQDREAFI DDPWLPGRRL YRSGDLAVLL PQGGVRLAGR ADHQVKVRGF RIEPGEIEAA
LRTQPGVRQA LVLAAPDGAL AACLAADHGQ ALPAWRAALA EVLPAQMQPS RWLVLPELPR
LGNGKVDRKA LLEQLGRQDS GTPDVVAQAQ GALAALLAQQ MAQLLERPAI AANEDFFELG
AHSLLVIKLI ARIRQSLALE AAPALVFDHP NAIALAAALQ AAAPDPDALE RLAQSRLESA
APAQADSMNA LTAGFPARHT RIPYRSMNDM SRPPHEHAPL SYSQQQLWFL QQYEPGLTAY
NLTRAFRLTG ALDRAALSAA LDALQARHAI LRTRFAETDG LPYQQAVPPF PVQLAWLDLR
QLPPQQREQR LQEELQAAAA HVFDLGQAGQ LDVRLIALGP QEHVLVIGMH HIVSDAWSNP
LVIRDLAEAY RQARRDGQAQ LPALPMQYAD YAHWQRQRVQ GAWLADELRY WDDYLGPVNS
SLDLPTDRPR PARQSFRGAV HAFTLDSALA QQMQAFCRAQ HCTPFVALMA AWQVLLSRYS
GQSDFLVGAP NAGRNHAELQ DLVGFFVTTQ LYRARLTPEL TVRELVRQVR GDMLAALEHG
DLPFEALLEH RKVERDPGRN PLFQVMFGLQ MVGEGASALA FDDIVTAPLP LAQDSAKFDL
SLDVKVIKGE VHCRLEYASD LFDAATIAAM AGHYRNLLRG FAEAPERPVA QLALLDQDEQ
ARLRSWGDPQ LREALPPTSS ASLAGLIEAQ AAAIPDAVAV VCGPQQMSYA QLNRAANRLA
HRLLQQGVGL EDRIGLAAPR SLEMIVGLLA ILKAGAAYVP LDPDYPADRL AYMVQACRRH
PGVDGRARVS LPGPRKACAH WRSPRPWADD AAPAHNPGVV LHPDNLAYII YTSGSTGRPK
GAQLSHANVL RLLGQTAAWF DFGREDVWTL FHSYAFDFSV WEIFGALCYG GRLVVVPFAV
SRSPEDFLAL LVEQRVTVLN QTPSAFRQLL QLPALRQLPS EALALRTVIF GGEALEPEML
RPWITQFGDQ RPALINMYGI TETTVHVTYR RLLRADLDAS RSPIGAAIPD LGLYVLDQQL
NLAPAGVPGE LYVSGAGLAR GYLNRAALSA ERFVANPFAR AGEEGSRLYR TGDLVRWRHD
GQMDYLGRID QQVKIRGFRI ELGEIEAQLL AQPGVGAATV MVRQDAATPR LVGYLSPQAG
IAPEALDTGA LRTALGAVLP DYMVPAALVM LPALPLNING KVDRKALPAP ELAARTAYAA
PQGALEEQLA AIWREVLKGG AVGRDDNFFE LGGDSILSLQ IVSRARRAGI AITARQMFER
QTVAELAAVA SEAVAAATPR AITHTAQAGQ ACRLLPIQQD FFEADIPRRA HWNQSVLLHS
DAPIDPAALA AALQALMQAH PALTMRYAQH SDGWRQLHGE LPTLQAIAER IVSARAADAE
QLLALCESAQ RSLDLEHGLV LRAVLVDMGQ AGWRLLLVAH HLVIDGVSWR VLLEDLQHAY
AHACATPHEA PQLPAEEAGP AEWGEALAAY APVAAQRIDH WLGLAGCPVQ LPSDPARAGE
EGASARLVDQ QSVLLRLTPA LTQTLIGEAH SAWRTQVNDL LLAALARALA AWGAPQPLLV
DLEGHGREAL GDGAATPDLS RTVGWFTSVF PLALEASGTP LATLLRTKES LRALPNKGLD
FGVLRRFGTA EQRAALQALP RAQVAFNYLG QFQSGEEGGW RLASESAGTP MDPQAAMRHA
LTINGQVHEG VLQLRLNYCS KRYGRAMVET LAAHLQAQLE ELAALCSQHA GGLTPSDLPL
AGLDQAQLDA LPLAARNVDD IYPLSPMQAG MLFHSVFEPG GSAYINQLRV DIDGLDAARF
EQAWQDTVAA HDILRTGFLH QPRPLQWVAR RVASPLSQLD WRDAAAGQSL GGELDALAQR
QLAQGFDLAA PPLMRLVLVR TGAQRHHLIW TVHHLLLDGW STSMLLGEVL RRYAQATAAG
QAKPTKLALR YRDYIGWLQG RDQEATRRFW EIQLARLQQP TRLADAMPRP STPESGHGEH
RELLDAALTA RLNEAARAQR ITLNTLVQAA WALLLQRYTY AAHDQGVVFG ATVAGRPAEL
TGVEQLLGLF INTLPVIVAT PPHQPAGDWM RALQAQNLQA REYEHTPLVD IQRWSGQGAQ
ALFDSILVFE NYPVDATLSQ GAPAGLAFSS VRHREETNYP MTVVVNAGDT LQLQLRYARA
QFAHEMVERI GAHLRHLLQV LAEHPQQAIG SLGLLPGDEL AAWRESGVNR ELHAFDAPVH
RLIERQAAAT PSAAALLYED LVLDYRSLNQ QANRLAHRLL AEGAGPERIV GVAARRAPEM
VVALLAVLKA GAAYLPLDPD LPPARLADMM ADSGLSLLLT QTALRAELTA PAAVRVLELD
APGQPWAEGM PDHDPGIEVA PDGLAYVIYT SGSTGKPKGA GNRHVSLHNR LAWMQEAYPI
GPGNTVLQKT PFGFDVSVWE FFWPLMTGAR LALAAPDEHR DPALLAARIR RHAVDTLHFV
PSMLQGFVAH PDSAQCHSLR QVICSGEALP AELQEQAFAR LPQIALHNLY GPTEAAIDVT
HWTCRPGERS VPIGRPISHT AAYVLDGGLN PLPHGIAGEL YLGGIGLARG YLGRPGLSAE
RFVADPFAAD GSRMYRTGDL VRRRADGEIE YLGRTDHQVK IRGLRIELGE IEAQLLAQPG
VAAAVVVALV EPGRPARLVG YAADPGGMLE AEALRAALLQ SLPDYMVPQR LILLPALPLN
ANGKVDRKAL PRPDFNEQGG YEAPQGQTEI GLAAIWAEVL RLQRVGRHDN FFELGGDSIL
SLQIVARAHE QGWPLTPRQL FQSQTVAELA QQCDQLQPPA PTQAVTAARG RLEDYLSAAQ
TAQLALQGEL EDVYPLSPMQ QGMLFHTMES PGSGLYVNQL SVRVEGLDEA RFAQAWQSVL
ARHPVMRTGF LWQADYAQPL QAVWRTLAFG IEVQDWSARA TMPSCRRRLP PLRRPILRAA
STCCNRPLVR ATLLRLGPGQ HQLVWTMHHI LLDGWSTSAL MQELMLAYGG QPLPAPGPDY
AQYIGWLATL DPQAAQRYWM GALQALDGPS LLAEGVRPDP ARRGFGKLYG HCDAAATRRL
EQFARSQRVT LNTLVQGAWS LALARHKRST AVAFGATVSG RPAALPGVEK SLGLFINTIP
IVVEVDGQRR VGDWLRTLQQ TNIDSREHEH TPLYDIQRWS GMAGRALFDS IIVFENFPIS
RSLEARAQAG LRFGQAEGEG LTGFAMDLQV VARETLDIEF CYDRSLFGDA EVEALREQVM
LNLDALSASG ERALGELARL SPQALAAVLE LGRGAHDYPA DLPAHLLIAQ RAAQTPDAIA
LVLEEQSLSY GELNVRANRL AHHLMSLGVG AEQRVGVAVE RSFDMVVGLL AVMKAGAAYV
PLDLDYPPER LAYMVADSRI RVLLTHARAR RLLAAQAQPG LRCLALDDAD LAAQLAGLPA
HDPVVAVAPQ QMAYVIYTSG STGQPKGVAV SHGPLVMHCQ ATAALYEMTP QWRELQFMSF
SFDGAHERWI TTLISGAALV LRGPEMWSIE QSWQALHQQR VSNAVFPPAY LGQLAQWGEQ
HGDAPPLELY VFGGEAMPRA SFERVRRHLA PRLLINGYGP TETVVTPLIW KGTSAAGVDF
DGPFVPIGKP VGRRNAYILD ACLQPVAPGE AGELYIGGDG LARGYLERPA QSAERFVADP
FGEPGARMYR TGDLARWLPD GNVEYLGRLD HQVKIRGFRI ELGEIEALLR RQPGVAEAAV
VVRSDGQGEE TVRQLVAYVG APQAVAAPET AQRDFSDSLR AALRAGLPEY MLPAHFVLLA
ALPVTHNGKL DRKALPAPQA APARSYVAPA TPAAQALAEI WQTVLKRERV GQEDNFFELG
GDSLLCLQVI ARARGQRQWN FNFKLADLMQ RPTIAALLGL ESRPADGPAL VAMNAGPQDV
APLFCLHAGM GTVFDYRPLA QALQGRRRVY GLPCAMLQDP AQAAPTLAQL ADHYTAQLRS
VQPQGPYHLL GWSLGATLAA QVAQRLEAQG TQVAFLGLVD GYVPQSEAAD ARDWLDDLQD
FVSVMLPASW DGAAGSKRWL ALQALQARQS GALPSEAAAL AMLSAMLEQA GELPASLPSA
GELARIFVVA RHLRQISAQA PALEAVAASP HYWWIARRKP AHRAELKRQL GQTGCAEVLL
ETDHFSIMKQ ARLLDEVVQA LEVLAGDCAD IAGAAMGRSS
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