ID D8JYT6_HYPDA Unreviewed; 209 AA.
AC D8JYT6;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 01-MAY-2013, entry version 15.
DE RecName: Full=Thymidylate kinase;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=tmk; OrderedLocusNames=Hden_1731;
OS Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NCIB
OS 11706 / TK 0415).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Hyphomicrobiaceae; Hyphomicrobium.
OX NCBI_TaxID=582899;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51888 / DSM 1869 / NCIB 11706 / TK 0415;
RX PubMed=21705585; DOI=10.1128/JB.05453-11;
RG US DOE Joint Genome Institute;
RA Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT "Genome sequences of eight morphologically diverse
RT alphaproteobacteria.";
RL J. Bacteriol. 193:4567-4568(2011).
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR EMBL; CP002083; ADJ23538.1; -; Genomic_DNA.
DR RefSeq; YP_003755859.1; NC_014313.1.
DR EnsemblBacteria; ADJ23538; ADJ23538; Hden_1731.
DR GeneID; 9387623; -.
DR KEGG; hdn:Hden_1731; -.
DR PATRIC; 42372095; VBIHypDen91677_1783.
DR HOGENOM; HOG000229078; -.
DR KO; K00943; -.
DR OMA; ITLEGPE; -.
DR BioCyc; HDEN582899:GIWL-1750-MONOMER; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR10344; PTHR10344; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW Nucleotide-binding; Transferase.
FT NP_BIND 11 18 ATP (By similarity).
SQ SEQUENCE 209 AA; 23213 MW; 081DE5C54E7C1181 CRC64;
MKRGKFITFE GGEGVGKSTQ AKRLAERLER AGVPVIITRE PGGTPVGEDV RDLIMKDRPT
DPMTELLLFA AARAEHVTSV IRPALDDGTW VISDRFIDST RVYQGKRYGL EPELISLLER
YTVSPDFPDL TLILDLPATE GVERAQNRGT LSRYDAERIE THEVLRKGFL EIATSEPKRC
VLIDASLPVS SVETAVWQAV SAHLLVEAR
//
