ID D9TN91_THETC Unreviewed; 409 AA.
AC D9TN91;
DT 05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2010, sequence version 1.
DT 01-MAY-2013, entry version 21.
DE RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 2;
DE EC=2.3.1.179;
GN OrderedLocusNames=Tthe_1491;
OS Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM
OS 571 / NCIB 9385 / NCA 3814) (Clostridium thermosaccharolyticum).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family III. Incertae Sedis;
OC Thermoanaerobacterium.
OX NCBI_TaxID=580327;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N.,
RA Mikhailova N., Hemme C.L., Woyke T.;
RT "Complete sequence of Thermoanaerobacterium thermosaccharolyticum DSM
RT 571.";
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC synthesis by the addition to an acyl acceptor of two carbons from
CC malonyl-ACP (By similarity).
CC -!- CATALYTIC ACTIVITY: (Z)-hexadec-11-enoyl-[acyl-carrier-protein] +
CC malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-
CC carrier-protein] + CO(2) + [acyl-carrier-protein].
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC -!- SIMILARITY: Belongs to the beta-ketoacyl-ACP synthases family.
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DR EMBL; CP002171; ADL69001.1; -; Genomic_DNA.
DR RefSeq; YP_003852085.1; NC_014410.1.
DR EnsemblBacteria; ADL69001; ADL69001; Tthe_1491.
DR GeneID; 9707047; -.
DR KEGG; ttm:Tthe_1491; -.
DR PATRIC; 42452329; VBITheThe89703_1511.
DR HOGENOM; HOG000060166; -.
DR KO; K09458; -.
DR UniPathway; UPA00094; -.
DR GO; GO:0033817; F:beta-ketoacyl-acyl-carrier-protein synthase II activity; IEA:EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR017568; 3-oxoacyl-ACP_synth-2.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR016038; Thiolase-like_subgr.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR PIRSF; PIRSF000447; KAS_II; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR TIGRFAMs; TIGR03150; fabF; 1.
DR PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Complete proteome; Fatty acid biosynthesis;
KW Lipid biosynthesis; Transferase.
SQ SEQUENCE 409 AA; 43764 MW; 2E4C56C4671E61F5 CRC64;
MNRVVITGIG AITPIGNSID ELWDSLINGR SGIDKVTRFD VSSYPTKLAA EVKDFEPTEY
IDKKEAKRMD RFTQFALASA KMALIDSGLD LEKEDLDRIG VIYGSGIGGI ETLENQQNIL
KEKGPGRVSP FFVPMMIADM AAGLISITFG LKGHNETIVN ACASSTNAIG DAFKVIERGD
ADVIVTGGSE AAITPLAIAG FCSMKAMSTN DDPKTACRPF DANRDGFIMG EGSATLILES
LEHAIKRGAK IYCEIVGYGA TADAYHITAP APEGAGAARA MKLALKDADI IPEDIDYINA
HGTSTEYNDK YETMAIKNVF GQHAYKLKVS STKSMTGHML GASGAVEAVA TVLAIKNGIV
PPTINYETPD PECDLDYVPN KALEMEINYA LSNSFGFGGH NATLVFKKY
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