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Database: UniProt/TrEMBL
Entry: E0VAB8_PEDHC
LinkDB: E0VAB8_PEDHC
Original site: E0VAB8_PEDHC 
ID   E0VAB8_PEDHC            Unreviewed;       627 AA.
AC   E0VAB8;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   05-JUL-2017, entry version 43.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   Name=8232297 {ECO:0000313|VectorBase:PHUM034490-PA};
GN   ORFNames=Phum_PHUM034490 {ECO:0000313|EMBL:EEB10324.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura;
OC   Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|EMBL:EEB10324.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB10324.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB10324.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB10324.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000009046, ECO:0000313|VectorBase:PHUM034490-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046,
RC   ECO:0000313|VectorBase:PHUM034490-PA};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A.,
RA   Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E.,
RA   Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A.,
RA   Veenstra J.A., Walenz B., Tubio J.M., Ribeiro J.M., Rozas J.,
RA   Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L.,
RA   Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M.,
RA   Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P.,
RA   Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M.,
RA   Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F.,
RA   Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G.,
RA   Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C.,
RA   Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L.,
RA   Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C.,
RA   Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [4] {ECO:0000313|VectorBase:PHUM034490-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|VectorBase:PHUM034490-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; DS235005; EEB10324.1; -; Genomic_DNA.
DR   RefSeq; XP_002423062.1; XM_002423017.1.
DR   ProteinModelPortal; E0VAB8; -.
DR   STRING; 121225.PHUM034490-PA; -.
DR   EnsemblMetazoa; PHUM034490-RA; PHUM034490-PA; PHUM034490.
DR   GeneID; 8232297; -.
DR   KEGG; phu:Phum_PHUM034490; -.
DR   VectorBase; PHUM034490-RA; PHUM034490-PA; PHUM034490.
DR   CTD; 8232297; -.
DR   InParanoid; E0VAB8; -.
DR   KO; K01283; -.
DR   OMA; AYIVDQW; -.
DR   PhylomeDB; E0VAB8; -.
DR   Proteomes; UP000009046; Partially assembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   CDD; cd06461; M2_ACE; 1.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144,
KW   ECO:0000313|EMBL:EEB10324.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009046};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144,
KW   ECO:0000313|EMBL:EEB10324.1};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
SQ   SEQUENCE   627 AA;  73489 MW;  830344A1E3864A2B CRC64;
     MFLLFLFLFA KFAFSQDTTN IEGNNESLEE ALQFLREYDV EGSAICTRVT LAQWNFSTNV
     STINRKKMVC YNKCGNDYGR TVMEQTLYDK FQKLSRRKAT EFAWTKLPDP DVRRQMKKLI
     TQGRFSLHDD QFNELKDVIS QMKEIYTKGT ICPYNKNPVY CDQKLEPTLT KIMAKSRDYH
     ELLHVWKSWR DAVGPPIRQK YIRYVELANQ AARLDGFNDA GDQMKSVYEI PNFEDHLSEL
     WNMIEPFYKQ LHAYVRRKLI KFYGSKYIRH DGPIPAHLLG NMWAQSWKNI EELIIPYPGK
     TIGDITPELI RQVAEEFFIS LGLKPMPPEF WRHSLLEKPI GREVVCRASA WDFCNKMDYR
     IKQCTEVTME DFLTIHHEMA HIEYYLQYAD QPYLYREGAN PAFHEAVGDV IVLSVQTPRH
     LQRIGLLNNI TDDYETNINY LLSMALEKVV YLPFAYIVDK WRWNVFAEGI NNMNSKWWEL
     KLNYQGLIPP VPRSESDFDA AAKYHVASDT PYIRYFLSVI IQFQLYESLC EASGHYGPLH
     TCDIYRSREA GRLLREILQS GSSRSWSDVI NVMTKGKIKK ISASSLLNYF KPLLTWLEVQ
     NKEELYVGWT TGPHDTGKIM DDVITRR
//
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