ID E0VBY4_PEDHC Unreviewed; 405 AA.
AC E0VBY4;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN Name=8231289 {ECO:0000313|EnsemblMetazoa:PHUM075600-PA};
GN ORFNames=Phum_PHUM075600 {ECO:0000313|EMBL:EEB10890.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB10890.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10890.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB10890.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB10890.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM075600-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM075600-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ECSIT family.
CC {ECO:0000256|ARBA:ARBA00007674}.
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DR EMBL; AAZO01000906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235044; EEB10890.1; -; Genomic_DNA.
DR RefSeq; XP_002423628.1; XM_002423583.1.
DR AlphaFoldDB; E0VBY4; -.
DR STRING; 121224.E0VBY4; -.
DR EnsemblMetazoa; PHUM075600-RA; PHUM075600-PA; PHUM075600.
DR GeneID; 8231289; -.
DR KEGG; phu:Phum_PHUM075600; -.
DR CTD; 8231289; -.
DR VEuPathDB; VectorBase:PHUM075600; -.
DR eggNOG; KOG3941; Eukaryota.
DR HOGENOM; CLU_046917_1_0_1; -.
DR InParanoid; E0VBY4; -.
DR OMA; EEDFSHW; -.
DR OrthoDB; 4098911at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR029342; ECIST_C.
DR InterPro; IPR010418; ECSIT.
DR InterPro; IPR046448; ECSIT_N.
DR PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR Pfam; PF14784; ECSIT_C; 1.
DR Pfam; PF06239; ECSIT_N; 1.
DR SMART; SM01284; ECSIT_Cterm; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 272..396
FT /note="ECSIT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01284"
SQ SEQUENCE 405 AA; 47147 MW; 8D58329294171742 CRC64;
MSNFFFKVFS VKSFRPLSKQ WQRKKCQEVI VVGSRKISSH VLSTNFSSNT KILSKTFKHF
KSIQITSQLK YCDEKKNKII TFSDFEKWSV KNKESFLETI RIYEATFPNR KGHVEFVESA
LKQMETYGVH KDIEAYKRII DILPKGVFVV KNKWQATFYN YPRQQFAAIE MLSKMEHYGV
LPDAELGSIL ISIFGKFSQP CLKYFEQLYW CMKFRNKSPW YLPKQVPSDA FLLAQMAMER
ITSVDVKTEI SVYQTDDLLE SIDKTWIISG QSPVQKKLLN KHPSSTPLRV EGGDFVWLRD
QFVNYFVLKA DRDETCNWVP PKENEDLLTM ESQYFNPNYS NPEEPTKTVH HQNDGIVLAI
AITGTSSKDS LLSWIRFLEK NGNSGLKNIP ILFKLKTPER VPVTQ
//
