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Database: UniProt/TrEMBL
Entry: E0VJG1_PEDHC
LinkDB: E0VJG1_PEDHC
Original site: E0VJG1_PEDHC 
ID   E0VJG1_PEDHC            Unreviewed;      2688 AA.
AC   E0VJG1;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   05-JUL-2017, entry version 50.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|SAAS:SAAS00591749};
DE            EC=2.1.1.43 {ECO:0000256|SAAS:SAAS00591749};
GN   Name=8230790 {ECO:0000313|VectorBase:PHUM244720-PA};
GN   ORFNames=Phum_PHUM244720 {ECO:0000313|EMBL:EEB13517.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura;
OC   Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|EMBL:EEB13517.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB13517.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB13517.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB13517.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000009046, ECO:0000313|VectorBase:PHUM244720-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046,
RC   ECO:0000313|VectorBase:PHUM244720-PA};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A.,
RA   Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E.,
RA   Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A.,
RA   Veenstra J.A., Walenz B., Tubio J.M., Ribeiro J.M., Rozas J.,
RA   Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L.,
RA   Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M.,
RA   Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P.,
RA   Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M.,
RA   Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F.,
RA   Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G.,
RA   Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C.,
RA   Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L.,
RA   Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C.,
RA   Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [4] {ECO:0000313|VectorBase:PHUM244720-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|VectorBase:PHUM244720-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
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DR   EMBL; DS235222; EEB13517.1; -; Genomic_DNA.
DR   RefSeq; XP_002426255.1; XM_002426210.1.
DR   STRING; 121225.PHUM244720-PA; -.
DR   EnsemblMetazoa; PHUM244720-RA; PHUM244720-PA; PHUM244720.
DR   GeneID; 8230790; -.
DR   KEGG; phu:Phum_PHUM244720; -.
DR   VectorBase; PHUM244720-RA; PHUM244720-PA; PHUM244720.
DR   CTD; 8230790; -.
DR   InParanoid; E0VJG1; -.
DR   KO; K06101; -.
DR   Proteomes; UP000009046; Partially assembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.920.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00384; AT_hook; 4.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009046};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00591173};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:EEB13517.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:EEB13517.1}; Zinc {ECO:0000256|SAAS:SAAS00592951};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00592111}.
FT   DOMAIN     1892   1943       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     1946   2062       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     2070   2086       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2250   2320       Bromo. {ECO:0000259|PROSITE:PS50014}.
FT   DOMAIN     2443   2583       BAH. {ECO:0000259|PROSITE:PS51038}.
SQ   SEQUENCE   2688 AA;  306122 MW;  B999A46F4626BEFE CRC64;
     MPHNKGGPCV RSDILASTAW NALIHHPVED SDAEELPSTV DIDAIKGAPI TGHTGHWNSL
     NSNITKSNVE EKNESDSDDD KKISDSNSRS SSDSQSEDSE SGSCSWSSSS ESSSRSSSCS
     SQSAVQSRIS SPPSQTFSIR ESNFEQSSSR SQTGTESDSC SSMKHEKFKL GQLYMDEKEK
     MKKPTKVKSR LRFSGINDAK KKLHVDQGVD NKSLKETSMS SLKLTTSVTQ ISSTKKINKN
     GESKSSVNVK SKNDNLKTFN CNKTEETSKS ISMCEGPIIV GNKLNDSKSL SKKFNGKSII
     NKKLDSSTIK RDLDINKCCS IVMPSNKKLS EASKLRCVRK NTGSQYNKPQ SAIKPEAYSE
     SSESENDCSK DEAAHYTALA QQLSHIGNSE TLSSMSEHLQ VINQEDLAAI LPDVVTAENH
     GSFDGFEDVS LECGKNEKKN VNQDSGSDVE LPDQIVNDAI KRIHIDSEEM ENSESEKGNQ
     SSSDEDVEFR RGYSSSLLQQ FVEKTEILSA QCERLINVSR SRKIASQNSL LMENILERRI
     KRGRPPKIVK NSTSNNVESA QVVLGSVDRT NNKLMPELEA YRLDSSLSNV SPDSGIQSVP
     GSPVNENIHV SPCRDVTPPI LRPVTPVTGI PNKLSYLTKK SDISKKRPGR PKKIKLEVFR
     NLLQNNNQSE TKKDKNVKSE DRPPIHSLIP ERRGPGRPKK APPILEPNIP MVCRNELCKK
     ETRNNINIVL NEICERVSRQ LDFPSLSKES MRNVELNKED IERILLHHKS KKSRNLKFDA
     IFSKSMRLSN PPNVAIVKPM QHHRVEDNNV ENDKLNKKSG KKCKNGNLDE NTWYSVKLAC
     EKLNIAEKEK DFTDKKSRSF MDEKLNKGNK CKKKTEGKSK TKDLGHKSVG FVSTPRTFPT
     YKTLSTNDQL SKYFEKAKPN LQKKIHSLKK PRKNLKKSIK RKNGKTIHNL LHRKHKKCKR
     SMKHLKCKQK KLDNEWFFKE LEELITEFQK FSIGIVKKSI SLVTGNNLCT MQTVNSVQNE
     MGLPADFRVK RAVKKRKGSE KSRGSDRESG AEKSKLSDRE SGPELPENEV LREKPKRKQK
     KNHVEVINQG ADTNSNEQRL PLKKRHYHLT SASNQQLLPS WTSDSTQSIV KSINADKPIN
     KEVNSHLKKE AVEKIKCADS QKIQRNSIDE AIEATITRYT TKSCNVSPET NSDSNSTQSQ
     FNNQQCVITT PKKRHRVPDL VAKTVFQSNI CKNNNDVKSI LKNSDINVKT MLSLRHGAGN
     YTKVEPSCVQ NLIKTSNFIK ETNNKLFLPI ESKKKTGIKN ISKDIKGDKY VTGSTKGDIE
     KSDNDEIFTR NNDKIKKYGL KNSEHSEHLH FSKTSEERLK KYEFKNVLFE KTLSKTSQKQ
     HYTRSSSKTD MTPSDQTQSN NSKEVHLCKF NGSKESNEND HDDDKISEKL PEIEIFDSSL
     DAKYDGKTLS PTVNLQNEND KNSSNLKKYR DGRILQSVEE KRKDKSHKKL FTQKKGIRKS
     NYFKKPRCLK SCKEVRVNVK ESTPKDILIT KGVVEKKKVK RRKAINRTGF PSNKKKKKKM
     SIKLDEIEDK TASEMTKFSN PDGSATKLQE CETDKFSEDS NNKKNNLNLS TNTTDLNKSL
     DCPTNESVKT DDDENNLENN RGNQISLEET TVQDSITEER ESKVEGKVSE SSGTKRVRKN
     SSSLSDLVAK KVKTIKTENE EPKVKNNADL HKGIETTTGT ISTRKRKSLN TTKNINFGLN
     RYQYPLLSMK KFKRAKEELR AQSEESICDS VEEEVSKIKK SHPRWRKKYL AAGLFSDFYK
     QDPPQKVNKV NEKSLSKLVY LLADQELDLL PPPSYCNKYV RLRRVDYQLP FDLWWLHTHS
     QLPGRDIVPS WNYKKIRTNI YYDVKPQMTG TYEAQACNCT VPLNTKQKGC GEECINRMVF
     AECSPQLCPC KEKCSNQRIQ KHEFAPGLQK FMTKNKGWGI RTKQPIKAGD FILEYVGEVV
     SDKEFKDRMA SIYVNDKHHY CLHLDGGLVI DGHRMGGDGR FVNHSCNPNC EMQKWSVNGL
     FRMALFALRN IPAHQELTYD YNFSLFNPAE GQPCYCGTNE CRGVIGGKSQ RIPLGNGQNV
     VTSEKKEKKM VGRPRKTGKA KKHNVRDKNK IETVTVKPST KPMSHQQRCF VQMHHCFLLR
     NVDKVKRNKN NSKWNWKQSN NEVQSFSRQL PEIKQSDVFY TQLNALSTLR SIKTRRLAQA
     EDNPELTKVA KLAYIFKDLY SAVISAKDEK GELLSAPFTN LPPKRKLPAY YQRVSDPIDL
     ITIEQNINTG NYKTIEAFDQ DMTKLFNNNV KFYGRTSELG IASTRLRRVY CLAKYDSASE
     LEKVLGDAIP SSFIPENANP GDEEEDVIRC ICGLYKDEGV MIQCERCLVW QHCDCVKADD
     SVEHYLCERC DPREVNLEIL IDPQPEYATE DTTHYISLLR GDLQLRIGDA VYVLRDMIEE
     NTPKTSPPTK VTYKTIQNVN YADLDIFRIE RLWIDKKGDK FAFGHHYLRP HETYHEPTRK
     FFHNEVMRVP LYEVVPLDLI MNHCWVLDLN TYCKGRPIGA PEEHIYICEY RVDKSAHLFA
     KIAKPYLICT KTYAFEKFDV RLKPTRTYTV HEAKSESLKQ SESDEELPLA KIKENVHAAK
     RDEQKKRLNS ILLKLLSRLP NKQPLDLSYL LEPVKRFRGK AQQQGKRT
//
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