ID E0VXW7_PEDHC Unreviewed; 1289 AA.
AC E0VXW7;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=8232943 {ECO:0000313|EnsemblMetazoa:PHUM506080-PA};
GN ORFNames=Phum_PHUM506080 {ECO:0000313|EMBL:EEB18223.1};
OS Pediculus humanus subsp. corporis (Body louse).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura; Pediculidae;
OC Pediculus.
OX NCBI_TaxID=121224;
RN [1] {ECO:0000313|EMBL:EEB18223.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18223.1};
RA Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA Amedeo P., Strausberg R.;
RT "Annotation of Pediculus humanus corporis strain USDA.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEB18223.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=USDA {ECO:0000313|EMBL:EEB18223.1};
RG The Human Body Louse Genome Consortium;
RA Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT "The genome of the human body louse.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:PHUM506080-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:PHUM506080-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AAZO01006149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS235841; EEB18223.1; -; Genomic_DNA.
DR RefSeq; XP_002430961.1; XM_002430916.1.
DR STRING; 121224.E0VXW7; -.
DR EnsemblMetazoa; PHUM506080-RA; PHUM506080-PA; PHUM506080.
DR GeneID; 8232943; -.
DR KEGG; phu:Phum_PHUM506080; -.
DR CTD; 8232943; -.
DR VEuPathDB; VectorBase:PHUM506080; -.
DR eggNOG; KOG4258; Eukaryota.
DR HOGENOM; CLU_000288_166_0_1; -.
DR InParanoid; E0VXW7; -.
DR OMA; HRCWHHR; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000009046; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR CDD; cd00064; FU; 1.
DR CDD; cd05032; PTKc_InsR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF525; INSULIN-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00261; FU; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EEB18223.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW Transferase {ECO:0000313|EMBL:EEB18223.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 879..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1228..1255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 771..871
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 937..1212
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1265..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 971
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1289 AA; 147281 MW; DD6F34E0C7F91DE3 CRC64;
MTNRACKSCN ELINNITFPE LREVTGYVIF WRVQGLRSFG TLFPNLSVIR GKTLFHNYAL
VIYESKALQE IGLYSLTHIL RGSVRFDENS NLCFVDTIDW DWIAPQGAKE HFIGDNRPIE
ECLKCPISVN NEKCPLSSSG EPLCWNKEHC QKDFRDCVKD ENGECCHESC LGGCSGKLSK
DCYVCKNVVF KNDCTQECPE NMYKYLDRRC VTESECFNMT KPLDVEKRDI ASPFPFRPIL
DMCTLECPAN FSEYEKETEY GLRFQCRPCD GPCKKECPGG SINSISSAQK FAGCTHIKGS
LEIHLRFAGN IVTELQESLR SVEEISGYLK VARSLPLLSL DFLKNLKVIR GEELHNNKSA
FVLLDNERLE ELWDWDAREK DLRILNGRLA IHFNPKLCFY KIEKFVEIVK IKGFTEDEVP
RGTNGDKEAC ELSVVGCCRL FSFPNKVVIR FEKFQHYDQR TLLGYVLYFK KAPNKNVTLY
YGRNACGGDG WMDKDVPAPK QDNHQNEISY DLIGLKPFTQ YAYFIKTYAI SSERSGARSG
IQYFITNPGT PTSPRSLFAF SNSTSEVVIS WEPPAEMNGN FTHYFVEAEA MEDHPKSRDF
CSEPLVIATK KLEIPTSPPP AVKTSSDSCA CEAPRKVDLK VSEAVRDSEI YFENALQNSF
IVRSCYHHYH YFLSFFRTDN KRTKREMNYA EGSHPQILQK NHFFNEGVGG KSFGNTKKEK
VSFTFEVRTN KLVVRNLNYF TNYKIQVQAC RAVVEGENGV HSPCKTADKI PVITLIPLTS
NGTVEETNLR WEEPPNPNGL ILSYQIEYRR VDNDKYKSVV ECIVREKFLE QKKEYVLKHL
PPGNYSVRVL ASSLAGDGPY SSPLTFYIRQ PPHPSTIDIL GIGLGAICGI AFIFILYMFW
KRKTSGVPKL FANVNPEYVS AATIYVPDEW EVPRENIELI RELGQGSFGM VYEGIARDIV
QGEPEVRCAV KTVNEVSTDR DRMEFLNEAS VMKAFNTHHV VQLLGVVSEG QPTLVVMELM
VNGDLKTYLR SHRPEFCEDK KKQPPTLRRI IRMAMEIADG MAYLAAKKFV HRDLAARNCM
VAEDLTVKIG DFGMTRDIYE TDYYKKGTKG LLPVRWMAPE SLKDGVFTTH SDVWSYGIVL
WEMVTLASQP YQGLSNDQVL RYVIEGGVME RPENCPNKLY DLMKLCWQHK PSSRPHFMSF
VTKLLPDASP EFCEKSYYHS REGQELRWFI IFSLSLSLSF SFVLYRLIFF CFWNVQSAFR
SSGKFENESI SNDGGDDSDD DDRDSITIS
//