GenomeNet

Database: UniProt/TrEMBL
Entry: E0VZV0_PEDHC
LinkDB: E0VZV0_PEDHC
Original site: E0VZV0_PEDHC 
ID   E0VZV0_PEDHC            Unreviewed;      1146 AA.
AC   E0VZV0;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   22-NOV-2017, entry version 44.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   Name=8235461 {ECO:0000313|VectorBase:PHUM538580-PA};
GN   ORFNames=Phum_PHUM538580 {ECO:0000313|EMBL:EEB18906.1};
OS   Pediculus humanus subsp. corporis (Body louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Paraneoptera; Psocodea; Phthiraptera; Anoplura;
OC   Pediculidae; Pediculus.
OX   NCBI_TaxID=121224 {ECO:0000313|Proteomes:UP000009046};
RN   [1] {ECO:0000313|EMBL:EEB18906.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB18906.1};
RA   Kirkness E., Hannick L., Hass B., Bruggner R., Lawson D., Bidwell S.,
RA   Joardar V., Caler E., Walenz B., Inman J., Schobel S., Galinsky K.,
RA   Amedeo P., Strausberg R.;
RT   "Annotation of Pediculus humanus corporis strain USDA.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EEB18906.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=USDA {ECO:0000313|EMBL:EEB18906.1};
RG   The Human Body Louse Genome Consortium;
RA   Kirkness E., Walenz B., Hass B., Bruggner R., Strausberg R.;
RT   "The genome of the human body louse.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000009046, ECO:0000313|VectorBase:PHUM538580-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA {ECO:0000313|Proteomes:UP000009046,
RC   ECO:0000313|VectorBase:PHUM538580-PA};
RX   PubMed=20566863; DOI=10.1073/pnas.1003379107;
RA   Kirkness E.F., Haas B.J., Sun W., Braig H.R., Perotti M.A.,
RA   Clark J.M., Lee S.H., Robertson H.M., Kennedy R.C., Elhaik E.,
RA   Gerlach D., Kriventseva E.V., Elsik C.G., Graur D., Hill C.A.,
RA   Veenstra J.A., Walenz B., Tubio J.M., Ribeiro J.M., Rozas J.,
RA   Johnston J.S., Reese J.T., Popadic A., Tojo M., Raoult D., Reed D.L.,
RA   Tomoyasu Y., Krause E., Mittapalli O., Margam V.M., Li H.M.,
RA   Meyer J.M., Johnson R.M., Romero-Severson J., Vanzee J.P.,
RA   Alvarez-Ponce D., Vieira F.G., Aguade M., Guirao-Rico S., Anzola J.M.,
RA   Yoon K.S., Strycharz J.P., Unger M.F., Christley S., Lobo N.F.,
RA   Seufferheld M.J., Wang N., Dasch G.A., Struchiner C.J., Madey G.,
RA   Hannick L.I., Bidwell S., Joardar V., Caler E., Shao R., Barker S.C.,
RA   Cameron S., Bruggner R.V., Regier A., Johnson J., Viswanathan L.,
RA   Utterback T.R., Sutton G.G., Lawson D., Waterhouse R.M., Venter J.C.,
RA   Strausberg R.L., Berenbaum M.R., Collins F.H., Zdobnov E.M.,
RA   Pittendrigh B.R.;
RT   "Genome sequences of the human body louse and its primary endosymbiont
RT   provide insights into the permanent parasitic lifestyle.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:12168-12173(2010).
RN   [4] {ECO:0000313|VectorBase:PHUM538580-PA}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|VectorBase:PHUM538580-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
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DR   EMBL; DS235854; EEB18906.1; -; Genomic_DNA.
DR   RefSeq; XP_002431644.1; XM_002431599.1.
DR   ProteinModelPortal; E0VZV0; -.
DR   STRING; 121225.PHUM538580-PA; -.
DR   EnsemblMetazoa; PHUM538580-RA; PHUM538580-PA; PHUM538580.
DR   GeneID; 8235461; -.
DR   KEGG; phu:Phum_PHUM538580; -.
DR   VectorBase; PHUM538580-RA; PHUM538580-PA; PHUM538580.
DR   CTD; 8235461; -.
DR   InParanoid; E0VZV0; -.
DR   KO; K11407; -.
DR   OMA; QPHGFCI; -.
DR   PhylomeDB; E0VZV0; -.
DR   Proteomes; UP000009046; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.40.800.20; -; 2.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR10625; PTHR10625; 3.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF52768; SSF52768; 2.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009046};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009046};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    977   1007       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1050   1111       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   ZN_FING    1050   1111       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
SQ   SEQUENCE   1146 AA;  129337 MW;  A3809B9688E520E8 CRC64;
     MDKSTSNKPL NRRSPRTCAA RTSSSILAAK ESMKMKMKKN QDDDFIRDDY ATAQEAKTII
     AGKTGIVYDD QMVKHFCMWD KNYPENPERF SKIIERCKEL KLIDRCTRIE SRLATEEEIL
     TQHTIDKIKV LKETQNENDE TKLEQLSSKY DSVYVNNFTY ECSLLAVGST IDLVDAICKG
     EIQNGMAIIR PPGHHAMRDE YCGYCFYNNV AIAAQLALKK FNLQRILIVD WDIHHGQATQ
     QMFYDDKRVV YFSIHRYDHG SFWPELRESN FHYIGDSAGK GKNFNIPLNE TGMKDADYLA
     IFQQVLLPMA YEFQPELIII SAGYDAAINC PEGSMEVSPA CYSHLLSPLM GLAGGKVAVI
     LEGGYCLKSL SEGVALTLRT LLGDPAPSLI DFGLPCDSVV ESILNVIYVH KPYWQCFQLQ
     DAYDVDVNEG GGIKTRKKST EKPSIAPTTK RHHPVVKFIG NETKLDFYPT RDCYPIQEEE
     TFKKLDQKLN HLKLVTDLRV PPNRVAFGYD EKMTEHRNNQ ESNHPEKPER ITKIFLMHRD
     YNLLERCLSI KSRMATEEEI LLSHTNSHLE DMKKLPTMSA EELNEKGNSY DSIYLHSKSY
     ECALLAAGTL LQVVDSVING EARSGVAVVR PPGHHAEDDT ACGFCLFNNV SIAAKYAIEV
     HSLKRILVLD WDVHHGNGTQ KIFEEDDRVL YISLHRYNHG RFFPTTKEGD HDRVGIGRGE
     GFNVNIPWNR PGGGMSDGDY IAAFHSIVLP IAYQFNPELV LVSAGFDACI HDPLGHCKVT
     PEAYAHMTHW LTTLANGKVI LSLEGGYNVT SISYALTLCT KALLGDPLPP LTTTLAPCSS
     AVETIQNVLN TQEKYWPCLK FNVALPKDYV LKNSESNMGD SPKLVNNSYE KNEDLIEKMQ
     SLKFENITLK GDQEVCDAPE DGNPRDARSR EGRSSRDSDH ESGAAARPNA QTLVVDPVII
     SSLRVVGLQE YTTTPGWFFF LLVSSSVQLV FFLLSSSVQF FFFFFSLKGY LSDNMQRLLN
     QEMFAVVPLP GCPHLVQVQA VPQSGIDVNT PCGTCDSQQE NWICLICYLV FCGRYINQHM
     MFHNEESTHP LALSFTDLSV WCYVCEAYID NMILYPAKNA VHRSKFGSDL EWSYGDRTPN
     TRLSNR
//
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