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Database: UniProt/TrEMBL
Entry: E1QQJ4_VULDI
LinkDB: E1QQJ4_VULDI
Original site: E1QQJ4_VULDI 
ID   E1QQJ4_VULDI            Unreviewed;       438 AA.
AC   E1QQJ4;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   11-JUN-2014, entry version 28.
DE   RecName: Full=Adenosylhomocysteinase;
DE            EC=3.3.1.1;
DE   AltName: Full=S-adenosyl-L-homocysteine hydrolase;
GN   Name=ahcY; OrderedLocusNames=Vdis_1101;
OS   Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 /
OS   IC-017).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales;
OC   Thermoproteaceae; Vulcanisaeta.
OX   NCBI_TaxID=572478;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14429 / JCM 11212 / NBRC 100878 / IC-017;
RX   DOI=10.4056/sigs.1113067;
RA   Mavromatis K., Sikorski J., Pabst E., Teshima H., Lapidus A.,
RA   Lucas S., Nolan M., Glavina Del Rio T., Cheng J., Bruce D.,
RA   Goodwin L., Pitluck S., Liolios K., Ivanova N., Mikhailova N.,
RA   Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.,
RA   Jeffries C., Rohde M., Spring S., Goker M., Wirth R., Woyke T.,
RA   Bristow J., Eisen J., Markowitz V., Hugenholtz P., Klenk H.,
RA   Kyrpides N.;
RT   "Complete genome sequence of Vulcanisaeta distributa type strain (IC-
RT   017T).";
RL   Stand. Genomic Sci. 3:117-125(2010).
CC   -!- FUNCTION: May play a key role in the regulation of the
CC       intracellular concentration of adenosylhomocysteine (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L-
CC       homocysteine + adenosine.
CC   -!- COFACTOR: Binds 1 NAD per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-
CC       homocysteine from S-adenosyl-L-homocysteine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
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DR   EMBL; CP002100; ADN50489.1; -; Genomic_DNA.
DR   RefSeq; YP_003901540.1; NC_014537.1.
DR   ProteinModelPortal; E1QQJ4; -.
DR   EnsemblBacteria; ADN50489; ADN50489; Vdis_1101.
DR   GeneID; 9752032; -.
DR   KEGG; vdi:Vdis_1101; -.
DR   HOGENOM; HOG000227987; -.
DR   KO; K01251; -.
DR   OMA; EAIMDGF; -.
DR   BioCyc; VDIS572478:GHT7-1120-MONOMER; -.
DR   UniPathway; UPA00314; UER00076.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004013; F:adenosylhomocysteinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.50.720; -; 1.
DR   HAMAP; MF_00563; AdoHcyase; 1.
DR   InterPro; IPR000043; Adenosylhomocysteinase.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR   PANTHER; PTHR23420; PTHR23420; 1.
DR   Pfam; PF05221; AdoHcyase; 1.
DR   Pfam; PF00670; AdoHcyase_NAD; 1.
DR   PIRSF; PIRSF001109; Ad_hcy_hydrolase; 1.
DR   SMART; SM00996; AdoHcyase; 1.
DR   SMART; SM00997; AdoHcyase_NAD; 1.
DR   TIGRFAMs; TIGR00936; ahcY; 1.
DR   PROSITE; PS00738; ADOHCYASE_1; 1.
DR   PROSITE; PS00739; ADOHCYASE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
FT   NP_BIND     170    172       NAD (By similarity){EA3}.
FT   NP_BIND     233    238       NAD (By similarity){EA3}.
FT   NP_BIND     313    315       NAD (By similarity){EA3}.
FT   BINDING      53     53       Substrate (By similarity){EA3,EA6}.
FT   BINDING     124    124       Substrate (By similarity){EA3,EA6}.
FT   BINDING     169    169       Substrate (By similarity){EA3,EA6}.
FT   BINDING     199    199       Substrate (By similarity){EA3,EA6}.
FT   BINDING     203    203       Substrate (By similarity){EA3,EA6}.
FT   BINDING     204    204       NAD (By similarity){EA3}.
FT   BINDING     257    257       NAD (By similarity){EA3}.
FT   BINDING     360    360       NAD (By similarity){EA3}.
SQ   SEQUENCE   438 AA;  48295 MW;  20E53065BBA2F71A CRC64;
     MTYKVKDISL AEKGRLLIEW AERHMPVLMK IRERFTREKP LDGIRISASL HVTKETAVLV
     RTLVAGGATV TLVPSNPLST QDEVAAALAE DGIYVYAWKG MNEREYYNAI GFAISQEPVV
     TMDDGADLTV TLHKLALGVK SNEVNYALET AGDRDFAKLI SSVYGGTEET TTGVIRLRAM
     AREGTLRYPI IAVNDSYTKY LFDNRYGTGQ STWDGILRAT NILVAGKVVV VAGYGWVGRG
     IAMRAKGLGA RRVIVTEVNP VRALEAVFDG FEVMPMSEAA EIGDIFITAT GDINAITLDH
     ILKMKDGAVL ANAGHFNVEI DVAGLERVAA EKRKIRDYVV EYRLPNGKRV YLLAEGRLVN
     LVAAEGHPSE VMDMSFSNQA LAVEYIVKNR GKLQLGVHKL PDELDMEVAR LKLETMGIRI
     DQLTEEQRRY ISSWGLGT
//
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