ID E1QQJ4_VULDI Unreviewed; 438 AA.
AC E1QQJ4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 01-MAY-2013, entry version 23.
DE RecName: Full=Adenosylhomocysteinase;
DE EC=3.3.1.1;
DE AltName: Full=S-adenosyl-L-homocysteine hydrolase;
GN Name=ahcY; OrderedLocusNames=Vdis_1101;
OS Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 /
OS IC-017).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales;
OC Thermoproteaceae; Vulcanisaeta.
OX NCBI_TaxID=572478;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14429 / JCM 11212 / NBRC 100878 / IC-017;
RX DOI=10.4056/sigs.1113067;
RA Mavromatis K., Sikorski J., Pabst E., Teshima H., Lapidus A.,
RA Lucas S., Nolan M., Glavina Del Rio T., Cheng J., Bruce D.,
RA Goodwin L., Pitluck S., Liolios K., Ivanova N., Mikhailova N.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.,
RA Jeffries C., Rohde M., Spring S., Goker M., Wirth R., Woyke T.,
RA Bristow J., Eisen J., Markowitz V., Hugenholtz P., Klenk H.,
RA Kyrpides N.;
RT "Complete genome sequence of Vulcanisaeta distributa type strain (IC-
RT 017T).";
RL Stand. Genomic Sci. 3:117-125(2010).
CC -!- FUNCTION: May play a key role in the regulation of the
CC intracellular concentration of adenosylhomocysteine (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L-
CC homocysteine + adenosine.
CC -!- COFACTOR: Binds 1 NAD per subunit (By similarity).
CC -!- PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-
CC homocysteine from S-adenosyl-L-homocysteine: step 1/1.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
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DR EMBL; CP002100; ADN50489.1; -; Genomic_DNA.
DR RefSeq; YP_003901540.1; NC_014537.1.
DR ProteinModelPortal; E1QQJ4; -.
DR EnsemblBacteria; ADN50489; ADN50489; Vdis_1101.
DR GeneID; 9752032; -.
DR KEGG; vdi:Vdis_1101; -.
DR HOGENOM; HOG000227987; -.
DR KO; K01251; -.
DR OMA; TIGMALH; -.
DR UniPathway; UPA00314; UER00076.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004013; F:adenosylhomocysteinase activity; IEA:HAMAP.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:HAMAP.
DR Gene3D; 3.40.50.720; -; 1.
DR HAMAP; MF_00563; AdoHcyase; 1; -.
DR InterPro; IPR000043; Adenosylhomocysteinase.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR PANTHER; PTHR23420; PTHR23420; 1.
DR Pfam; PF05221; AdoHcyase; 1.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR PIRSF; PIRSF001109; Ad_hcy_hydrolase; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR TIGRFAMs; TIGR00936; ahcY; 1.
DR PROSITE; PS00738; ADOHCYASE_1; 1.
DR PROSITE; PS00739; ADOHCYASE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
FT NP_BIND 170 172 NAD (By similarity).
FT NP_BIND 233 238 NAD (By similarity).
FT NP_BIND 313 315 NAD (By similarity).
FT BINDING 53 53 Substrate (By similarity).
FT BINDING 124 124 Substrate (By similarity).
FT BINDING 169 169 Substrate (By similarity).
FT BINDING 199 199 Substrate (By similarity).
FT BINDING 203 203 Substrate (By similarity).
FT BINDING 204 204 NAD (By similarity).
FT BINDING 257 257 NAD (By similarity).
FT BINDING 360 360 NAD (By similarity).
SQ SEQUENCE 438 AA; 48295 MW; 20E53065BBA2F71A CRC64;
MTYKVKDISL AEKGRLLIEW AERHMPVLMK IRERFTREKP LDGIRISASL HVTKETAVLV
RTLVAGGATV TLVPSNPLST QDEVAAALAE DGIYVYAWKG MNEREYYNAI GFAISQEPVV
TMDDGADLTV TLHKLALGVK SNEVNYALET AGDRDFAKLI SSVYGGTEET TTGVIRLRAM
AREGTLRYPI IAVNDSYTKY LFDNRYGTGQ STWDGILRAT NILVAGKVVV VAGYGWVGRG
IAMRAKGLGA RRVIVTEVNP VRALEAVFDG FEVMPMSEAA EIGDIFITAT GDINAITLDH
ILKMKDGAVL ANAGHFNVEI DVAGLERVAA EKRKIRDYVV EYRLPNGKRV YLLAEGRLVN
LVAAEGHPSE VMDMSFSNQA LAVEYIVKNR GKLQLGVHKL PDELDMEVAR LKLETMGIRI
DQLTEEQRRY ISSWGLGT
//
