ID E1SJL1_PANVC Unreviewed; 347 AA.
AC E1SJL1;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 01-MAY-2013, entry version 19.
DE RecName: Full=Dihydroorotase;
DE Short=DHOase;
DE EC=3.5.2.3;
GN Name=pyrC; OrderedLocusNames=Pvag_0865;
OS Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Pantoea.
OX NCBI_TaxID=712898;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C9-1;
RX PubMed=20952567; DOI=10.1128/JB.01122-10;
RA Smits T.H., Rezzonico F., Kamber T., Goesmann A., Ishimaru C.A.,
RA Stockwell V.O., Frey J.E., Duffy B.;
RT "Genome sequence of the biocontrol agent Pantoea vagans strain C9-1.";
RL J. Bacteriol. 192:6486-6487(2010).
CC -!- CATALYTIC ACTIVITY: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-
CC aspartate.
CC -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC pathway; (S)-dihydroorotate from bicarbonate: step 3/3.
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SIMILARITY: Belongs to the DHOase family. Type 1 subfamily.
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DR EMBL; CP002206; ADO09062.1; -; Genomic_DNA.
DR RefSeq; YP_003930511.1; NC_014562.1.
DR ProteinModelPortal; E1SJL1; -.
DR EnsemblBacteria; ADO09062; ADO09062; Pvag_0865.
DR GeneID; 9789385; -.
DR KEGG; pva:Pvag_0865; -.
DR PATRIC; 42417784; VBIPanVag152020_1009.
DR HOGENOM; HOG000256259; -.
DR KO; K01465; -.
DR BioCyc; PVAG712898:GHQ2-1094-MONOMER; -.
DR UniPathway; UPA00070; UER00117.
DR GO; GO:0004151; F:dihydroorotase activity; IEA:HAMAP.
DR GO; GO:0008270; F:zinc ion binding; IEA:HAMAP.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019856; P:pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR HAMAP; MF_00219; PyrC_type1; 1; -.
DR InterPro; IPR006680; Amidohydro_1.
DR InterPro; IPR004721; DHOdimr.
DR InterPro; IPR002195; Dihydroorotase_CS.
DR Pfam; PF01979; Amidohydro_1; 1.
DR PIRSF; PIRSF001237; DHOdimr; 1.
DR TIGRFAMs; TIGR00856; pyrC_dimer; 1.
DR PROSITE; PS00483; DIHYDROOROTASE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis;
KW Zinc.
FT METAL 17 17 Zinc 1 (By similarity).
FT METAL 19 19 Zinc 1 (By similarity).
FT METAL 103 103 Zinc 1; via carbamate group (By
FT similarity).
FT METAL 103 103 Zinc 2; via carbamate group (By
FT similarity).
FT METAL 140 140 Zinc 2 (By similarity).
FT METAL 178 178 Zinc 2 (By similarity).
FT METAL 251 251 Zinc 1 (By similarity).
FT MOD_RES 103 103 N6-carboxylysine (By similarity).
SQ SEQUENCE 347 AA; 38287 MW; 023173F430A60583 CRC64;
MTAQPQQLTL RRPDDWHIHL RDDEMLKTVL PYTSAVNGRA IVMPNLVPPV TSVAAGEAYR
DRILAALPAD HAFTPLMTCY LTDSLDPDEL ERGFTAGLFT AAKLYPAHAT TNSSHGVTNI
ASIARVLDRM QTLGMPLLIH GEVTDAHIDI FDREARFIET VMVPLRSQFP ALKVVMEHIT
TQDAAEYVAD AGETLGATIT PQHLMFNRNH MLVGGIRPHL YCLPILKRNV HQEALRKVVA
SGNPRFFLGT DTAPHLRHLK EASCGCAGVF NAPTSLPAYA TVFEELNALE HFEAFCSENG
PRFYGLPLNE GTITLVREPW QVPESIALGS HSLVPFLAGE TLNWRIA
//
