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Database: UniProt/TrEMBL
Entry: E1SZR9_THESX
LinkDB: E1SZR9_THESX
Original site: E1SZR9_THESX 
ID   E1SZR9_THESX            Unreviewed;       791 AA.
AC   E1SZR9;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   16-APR-2014, entry version 26.
DE   RecName: Full=Endonuclease MutS2;
DE            EC=3.1.-.-;
GN   Name=mutS2; OrderedLocusNames=Thet_0890;
OS   Thermoanaerobacter sp. (strain X513).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacter.
OX   NCBI_TaxID=573062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=X513;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Daligault H., Davenport K., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA   Mikhailova N., Hemme C.L., Woyke T.;
RT   "Complete sequence of Thermoanaerobacter sp. X513.";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endonuclease that is involved in the suppression of
CC       homologous recombination and may therefore have a key role in the
CC       control of bacterial genetic diversity (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 Smr domain.
CC   -!- SIMILARITY: Contains Smr domain.
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DR   EMBL; CP002210; ADN54516.1; -; Genomic_DNA.
DR   RefSeq; YP_003903807.1; NC_014538.1.
DR   ProteinModelPortal; E1SZR9; -.
DR   EnsemblBacteria; ADN54516; ADN54516; Thet_0890.
DR   GeneID; 9760659; -.
DR   KEGG; thx:Thet_0890; -.
DR   PATRIC; 42445911; VBITheSp37765_0925.
DR   HOGENOM; HOG000135096; -.
DR   KO; K07456; -.
DR   OMA; HDQSSTG; -.
DR   BioCyc; TSP573062:GHR1-928-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00092; MutS2; 1.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR005747; MutS2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002625; Smr/MutS2_C.
DR   PANTHER; PTHR11361:SF14; PTHR11361:SF14; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   Pfam; PF01713; Smr; 1.
DR   PIRSF; PIRSF005814; MutS_YshD; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01069; mutS2; 1.
DR   PROSITE; PS50828; SMR; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA-binding; Endonuclease; Hydrolase;
KW   Nuclease; Nucleotide-binding.
FT   DOMAIN      714    789       Smr (By similarity).
FT   NP_BIND     335    342       ATP (By similarity).
SQ   SEQUENCE   791 AA;  89753 MW;  DAA0DA95124CD857 CRC64;
     MVRGINSRAI KSLEFDKIVE FIVGYCDSDL GKQKALDIVI KKDIEEIERE LDLLNEAISF
     ISSYGGISFA FEDIRDYIKK AQIDSVLYNQ ELLKIKKFLN LVSQIKGYFK NLQESDRFVR
     LKEYDKKVLP IKNLEKRIEN IIISEDEIAD DASPMLKALR RQKLSINEKI RATLNSIIST
     RQKELQEPII TVRQGRYVVP VKQEYRSTFK GIVHDQSSSG ATLFIEPMQV VDLNNELRQV
     ELKEKQEIQR ILFELSQEVK KYSQILFNDI EIVSELDFIF AKAKYSLKLK AVRPELNTMG
     YINLKKARHP LINQEVVVPI DIHIGKQFNT LVITGPNTGG KTVTLKTVGL LTLMAMAGLN
     IPAEEKSQVS IFEEVFVDIG DEQSIEQSLS TFSSHMTNIV SILQKVNKNC LVLLDELGAG
     TDPIEGAALA MSILDTLHKI GAKTIATTHY SELKQYALKI PGVENASVEF DVETLKPTYK
     LIISLPGKSN AFEISKRLGL PQQIIENARK YISGEALKFE DIIADVESKR RELEKANHEI
     AFLKKDVEIL KEELEKEKKK LQSERDKILK EAKEKARKII QEAKFTAEEI IKKIREAEES
     TQNKDRIIQE VREELKKNLE ELEEEVLKPK EAHYSRIPDN LKEGQTVYIV PLDQNGIVLS
     LPDKSGNVEV QAGILKMTVH ISNLRVAEEK EEEEVKKGYS KFVHEKSQSI STSIDVRGKN
     LDDALLEVEK YIDDAYLAGL KEVTIIHGRG TGVLRTGISQ FLRSNKHVKS FRLGKYGEGG
     DGVTIVELAN K
//
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