ID E2A6C2_CAMFO Unreviewed; 795 AA.
AC E2A6C2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Carnitine O-palmitoyltransferase I, liver isoform {ECO:0000313|EMBL:EFN71007.1};
GN ORFNames=EAG_09896 {ECO:0000313|EMBL:EFN71007.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN71007.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; GL437123; EFN71007.1; -; Genomic_DNA.
DR RefSeq; XP_011252290.1; XM_011253988.2.
DR AlphaFoldDB; E2A6C2; -.
DR STRING; 104421.E2A6C2; -.
DR EnsemblMetazoa; XM_011253988.3; XP_011252290.1; LOC105248916.
DR GeneID; 105248916; -.
DR KEGG; cfo:105248916; -.
DR InParanoid; E2A6C2; -.
DR OMA; NTEHSWG; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EFN71007.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..46
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 174..774
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT COILED 765..792
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 471
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 795 AA; 90962 MW; D13A8DB5DF5C4329 CRC64;
MAEAHSAVAF SFAITHEGWD VNFDREVLHL VWLSGVRSWK KRFFRFLNNL KSGVYPASLE
SLWITIMLVT AVHFAGYKVP YDLVGKVSPY LSGTSILAHL AGSFLVALFL WLAVIYAIRY
TLKLLLMYKG WIYESRGKTY KPSSLTKIWL LMVKLFSGWH KPMLYSFQGS LPRLPLPSVA
DTMTRYLRTV RPLLDDENYA RMERLATEFQ NGIGVKLQRY LILKSWWSTN YVSDWWEEYV
YLRGRSPLMV NSNFYGIDAI LSHPTNLQSA RAAAVIYSCL KYRRLIERQE LEPILVQGLV
PLCSWQYERV FNTTRIPGIE VDKIVHYQDA KHIVVYHKGR YFKVLIYYRN RILQACEIEL
QIQQILNDDS TPAEGEEKLA ALTAGERTIW AQTRKDFFAK GVNKASLDII EKAAFVVALD
DVAYEYDPNH PEKLDHYGRI LLHGKGYDRW FDKSFTLCIG TNGRIGFNAE HSWADAAVMS
HLWEYVICSE FLDREADAPV MGTLWEFIMA ADNEIGYQDG HNIGTPEFTP PAPLRLQWDL
NAKCIEAIEQ SYQVAHNILN DVELRIYVHD AYGKGLMKAN SVSPDAYIQM ALQLAYYRDA
GKFSLTYEAS MTRLFREGRT ETVRPCTIES SKWVKAMENK TITIDEKVKL LMDAVARHQK
SYQDAMCGKG IDRHLFCLYV VSKYLEVDSP FLKEVLSEPW RLSTSQTPHG QTAKLDLKKY
PNCISAGGGF GPVAHDGYGV SYIIAGENLI FFHVSSKRSS SKTDAARFAK EIEKALDDMK
NLLGQKKKIH QNGSA
//
