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Database: UniProt/TrEMBL
Entry: E3D7T3_GARV3
LinkDB: E3D7T3_GARV3
Original site: E3D7T3_GARV3 
ID   E3D7T3_GARV3            Unreviewed;       918 AA.
AC   E3D7T3;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   22-NOV-2017, entry version 43.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|SAAS:SAAS00946768};
DE            EC=4.1.1.31 {ECO:0000256|SAAS:SAAS00946768};
GN   Name=ppc {ECO:0000313|EMBL:ADP38241.1};
GN   OrderedLocusNames=HMPREF0421_20155 {ECO:0000313|EMBL:ADP38241.1};
OS   Gardnerella vaginalis (strain ATCC 14019 / 317).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Gardnerella.
OX   NCBI_TaxID=525284 {ECO:0000313|EMBL:ADP38241.1, ECO:0000313|Proteomes:UP000001453};
RN   [1] {ECO:0000313|EMBL:ADP38241.1, ECO:0000313|Proteomes:UP000001453}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14019 / 317 {ECO:0000313|Proteomes:UP000001453};
RX   PubMed=20865041; DOI=10.1371/journal.pone.0012411;
RA   Yeoman C.J., Yildirim S., Thomas S.M., Durkin A.S., Torralba M.,
RA   Sutton G., Buhay C.J., Ding Y., Dugan-Rocha S.P., Muzny D.M., Qin X.,
RA   Gibbs R.A., Leigh S.R., Stumpf R., White B.A., Highlander S.K.,
RA   Nelson K.E., Wilson B.A.;
RT   "Comparative genomics of Gardnerella vaginalis strains reveals
RT   substantial differences in metabolic and virulence potential.";
RL   PLoS ONE 5:E12411-E12411(2010).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle.
CC       {ECO:0000256|SAAS:SAAS00946761}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000256|SAAS:SAAS00946751}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00946766};
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|SAAS:SAAS00946753}.
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DR   EMBL; CP002104; ADP38241.1; -; Genomic_DNA.
DR   RefSeq; WP_004116485.1; NC_014644.1.
DR   RefSeq; YP_003985264.1; NC_014644.1.
DR   EnsemblBacteria; ADP38241; ADP38241; HMPREF0421_20155.
DR   GeneID; 9903691; -.
DR   KEGG; gvg:HMPREF0421_20155; -.
DR   PATRIC; fig|525284.18.peg.151; -.
DR   HOGENOM; HOG000238647; -.
DR   KO; K01595; -.
DR   OMA; PWVFGWT; -.
DR   OrthoDB; POG091H040O; -.
DR   Proteomes; UP000001453; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PTHR30523; 2.
DR   Pfam; PF00311; PEPcase; 2.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|SAAS:SAAS00946757};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001453};
KW   Kinase {ECO:0000313|EMBL:ADP38241.1};
KW   Lyase {ECO:0000256|SAAS:SAAS00946754, ECO:0000313|EMBL:ADP38241.1};
KW   Magnesium {ECO:0000256|SAAS:SAAS00946750};
KW   Pyruvate {ECO:0000313|EMBL:ADP38241.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001453};
KW   Transferase {ECO:0000313|EMBL:ADP38241.1}.
FT   ACT_SITE    181    181       {ECO:0000256|PROSITE-ProRule:PRU10111}.
FT   ACT_SITE    580    580       {ECO:0000256|PROSITE-ProRule:PRU10112}.
SQ   SEQUENCE   918 AA;  103252 MW;  B503CE7CE964BC27 CRC64;
     MTTQNQQVTP ADATIVTSGL GRKGPEEREL PASLKQDMDL CLHILRDVLG EFDEKLLTVF
     DEVRLNAVNA STAHFAQMVD AQGTEDDGLN KAVEKINGMD LPDMQLLARA FATYFHLANL
     CEENYRVSVL HQRECEVEES NPVDPVNELT CAYHKLLTEM SPAQAKELLN KLEFHPVFTA
     HPTEARRKAV AGKIRRISKL LSKHNRLGGS DKRENYRRLY NEIDALLRTS PIALKKPTPV
     EEADTILDIF DATLFNTIPL VYRRFDDWLL GKKAGLVPPR CPAFFHPGSW IGSDRDGNPN
     VTAKVSRQVA SKFSNHVLKA LEERTREVGK CLTMETRTTP PSVELLELWN RQREMSEQLT
     ENASDVSNSE PHRAVMLVMA DRLHHTISRN TDLMYHSCEE FIEDLRIVQR SLAEAGDARA
     AYGPLQDLIW QAQTFGFHMV EMEFRQHSLV HSRALEDIRE HGLHGERGPL QPMTREVLDT
     FRALGAIQKR NGMRAARRYI ISFAKSAQHV RDVFELNRLA FAHPQDAPTI DVIPLFEQLE
     DLQNSVNVLE EIIKIPEVQA RLKATGRKME VMLGYSDSSK DAGPTSATLA LHSAQERIAQ
     WAKDHDIDLT LFHGRGGAVG RGGGPANRAV LAQPVGSVNC RFKLTEQGEV IFARYGNPIL
     AIRHLESVAA ATLLQSAPSV EKTNTEMTHK YADMAQKLDV AAHNRFIDLL QTDDFTPWFS
     TVTPLSEIGL LPIGSRPAKR GLGAKSLDDL RTIPWVFSWA QARINLAAWY GLGTACEKFG
     DLETLRRAYE EWPLFSTFID NIEMSLAKTD ERIARMYLSL GDREDLSDKV LSEMQLTRKW
     VLQIVGDKWP LQHRHVLGQA IRVRSPYVDA LSVIQSLALH KLRNKVDKEE LSESQQAEFI
     YLILCTVSGV AAGLQNTG
//
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