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Database: UniProt/TrEMBL
Entry: E3J231_FRAIE
LinkDB: E3J231_FRAIE
Original site: E3J231_FRAIE 
ID   E3J231_FRAIE            Unreviewed;       741 AA.
AC   E3J231;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   07-JUN-2017, entry version 42.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ADP84136.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ADP84136.1};
GN   OrderedLocusNames=FraEuI1c_6152 {ECO:0000313|EMBL:ADP84136.1};
OS   Frankia inefficax (strain DSM 45817 / CECT 9037 / EuI1c).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=298654 {ECO:0000313|EMBL:ADP84136.1, ECO:0000313|Proteomes:UP000002484};
RN   [1] {ECO:0000313|EMBL:ADP84136.1, ECO:0000313|Proteomes:UP000002484}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45817 / CECT 9037 / EuI1c
RC   {ECO:0000313|Proteomes:UP000002484};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Beauchemin N., Sen A., Sur S.A., Gtari M., Wall L., Tisa L., Woyke T.;
RT   "Complete sequence of Frankia sp. EuI1c.";
RL   Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002299; ADP84136.1; -; Genomic_DNA.
DR   RefSeq; WP_013427254.1; NC_014666.1.
DR   STRING; 298654.FraEuI1c_6152; -.
DR   EnsemblBacteria; ADP84136; ADP84136; FraEuI1c_6152.
DR   KEGG; fri:FraEuI1c_6152; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; FSP298654:GHN6-6092-MONOMER; -.
DR   Proteomes; UP000002484; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002484};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ADP84136.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002484}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   741 AA;  78382 MW;  A005B1A2E98A469A CRC64;
     MTDSTIIYTF TDEAPALATY SFLPVIQAYA AAAGVPVDSR DISLAGRIIA TFSEYLDESQ
     RIGDALAELG ELALRPEANI IKLPNISASI PQLKAAVAEL QGKGYALPDY PDEPKTDEER
     AVRARYDSVK GSAVNPVLRE GNSDRRAPAS VKNYARNHPH KMGAWSADSK TNVATMGQND
     FASTEKSAVI GAGGALRIEL AAADGTTTVL KGSVKVLAGE VVDASVLRVG PLREFLTAQI
     ARAKAEDVLF SVHLKATMMK VSDPIIFGHV VRAFFPSTFA AYGETIAAAG LTPNDGLGAI
     LAGLAALPEG DAIKASFEAE IAAGPALAMV DSDRGITNLH VPSDIIVDAS MPAMIRTSGH
     MWGPDGSEAD TLAVLPDSSY AGVYQVVLDD CRAHGAYDPA TMGSVPNVGL MAQKAEEYGS
     HDKTFEIAAD GVVRVVDDAG TVVLEQPVAA GDIFRMCQTK DAPIRDWVKL AVTRARATGD
     PAVFWLDENR AHDAQLIAKV KAYLPEYDTT GLTIEILSPV AATAYSLERI RKGQNTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFLALAV SFEQFAQVTG NASAKILGET LDRATGTFLN ENKSPARRVG GIDNRGSHFY
     LALYWAQELA AQTADEQLAS AFAELAKSLA DQETTITGEL LAVQGSPTDI GGYYQPDPVK
     ASAVMRPSAT FNEAIATLNA G
//
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