ID E3RSC8_PYRTT Unreviewed; 1159 AA.
AC E3RSC8;
DT 11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTT_11781 {ECO:0000313|EMBL:EFQ91369.1};
OS Pyrenophora teres f. teres (strain 0-1) (Barley net blotch fungus)
OS (Drechslera teres f. teres).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=861557 {ECO:0000313|Proteomes:UP000001067};
RN [1] {ECO:0000313|EMBL:EFQ91369.1, ECO:0000313|Proteomes:UP000001067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0-1 {ECO:0000313|EMBL:EFQ91369.1,
RC ECO:0000313|Proteomes:UP000001067};
RX PubMed=21067574; DOI=10.1186/gb-2010-11-11-r109;
RA Ellwood S.R., Liu Z., Syme R.A., Lai Z., Hane J.K., Keiper F., Moffat C.S.,
RA Oliver R.P., Friesen T.L.;
RT "A first genome assembly of the barley fungal pathogen Pyrenophora teres f.
RT teres.";
RL Genome Biol. 11:R109.1-R109.14(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL534775; EFQ91369.1; -; Genomic_DNA.
DR RefSeq; XP_003300533.1; XM_003300485.1.
DR AlphaFoldDB; E3RSC8; -.
DR STRING; 861557.E3RSC8; -.
DR EnsemblFungi; EFQ91369; EFQ91369; PTT_11781.
DR KEGG; pte:PTT_11781; -.
DR eggNOG; KOG3417; Eukaryota.
DR eggNOG; KOG3655; Eukaryota.
DR HOGENOM; CLU_002632_0_0_1; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000001067; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001067};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 723..853
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 892..1129
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 70..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1159 AA; 129453 MW; 99350280AC72AFE6 CRC64;
MNGFSGTTDA GGMYVKALYD YQADDRTSLS FRTGDIIQVI TQLESGWWDG VIHGVRGWFP
SNYCAVVQRP SEDVEDDRDG ADADDDHDAR SVSGAEGDYS DADSLSAGND TILPIERNGP
HDKEEEAAFW IPQATPDGRL FYFNTLTGVS TMNLPLESPS ANESGPRNRT DVFIPEMSRP
PAELLASGSG YNMEDTDDET SASDFEGPGN KGSYSSRHRQ RLSGGLSSAT SMESMNAGYP
NRSYDQSGMS FAASTAIPPT GTTATSFANS PGLTGADGTS RKFYDDVSPV PLTWNRMVED
MRRAIERYKQ AINNSDRSEF VKRAEDISDH LRLLLAAGSG TTDNHSGNPS IISTNKALYP
HFRETMSRFS KLVLSSHIAA SDFPPPDSYS KCLKEAEGVL NGVFGFVEVA RQQRGEEIPR
LVPGFVVGNL TGGSWQNNGT DSHDANTSIF SDQDDYEPPV EPTLKLDSRI LERLQDLKRL
ITSNLRRLDE QLVLRDTVIS HRKHQAIGEH VCNAAGKVLE SCRPWLSTIE QINLASLDVE
VNGQQLNEFS VQKQKAYDVV SELVIACQGV AAPLGDEWAE LRGDSLEDRI NAVRAVTRDL
EATCNHQYGL LQSLSDTVPL SDIVNRGESR RNTDGELASH ARGPSGPERP LLGNIPKAET
YSAGTPLTGD DSKVEPVRSA NSNKKIKDFF GEVPVIPQQA IEETPEFLKL DHEGEISYDH
KSTPPQLKGG TLAGLVEQLT RHDRLDPAFN NTFLLTYRSF TTASELFEML VKRWSIQPPH
GLDKDDYQHW VDKKQKPIRF RVVNILKSWF DNYWMEGNDE EARILIQRVY NFAKDHVATT
STPGAAPLMT SVEQRSRGPD MPTKRLVLTL SAQTPQPILP KHMKKLKFLD IDATEFARQL
TIIESRLYGK IRPTECLNKT WQKKLSPGEP DPAANVKALI LHSNQLTNWV AQMILTQQDV
KRRVIVIKHF VNVADKCRQL NNFSTLTSII SALGTAPIHR LNRTWSAVNQ RSMATLESMR
KLMGSTKNFA EYRDTLHRAN PPCIPFFGVY LTDLTFIEDG IPSLIKRTNL INFAKRAKTA
EVIRDIQQYQ NVPYPLQPVP ELQDYILTNM QSAGDVHEMY EMSLSVEPRE REDEKIARYT
SYFSLDRMKR DQEDVVEVI
//