GenomeNet

Database: UniProt/TrEMBL
Entry: E4N6K4_KITSK
LinkDB: E4N6K4_KITSK
Original site: E4N6K4_KITSK 
ID   E4N6K4_KITSK            Unreviewed;       739 AA.
AC   E4N6K4;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   07-JUN-2017, entry version 39.
DE   SubName: Full=Putative NADP(+)-dependent isocitrate dehydrogenase {ECO:0000313|EMBL:BAJ26835.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:BAJ26835.1};
GN   Name=icd {ECO:0000313|EMBL:BAJ26835.1};
GN   OrderedLocusNames=KSE_09990 {ECO:0000313|EMBL:BAJ26835.1};
OS   Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC
OS   A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Kitasatospora.
OX   NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ26835.1, ECO:0000313|Proteomes:UP000007076};
RN   [1] {ECO:0000313|EMBL:BAJ26835.1, ECO:0000313|Proteomes:UP000007076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC   KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX   PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA   Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA   Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA   Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T.,
RA   Horinouchi S., Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A.,
RA   Nomoto F., Miura H., Takahashi Y., Fujita N.;
RT   "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT   snapshot of the family Streptomycetaceae.";
RL   DNA Res. 17:393-406(2010).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AP010968; BAJ26835.1; -; Genomic_DNA.
DR   RefSeq; WP_014134154.1; NC_016109.1.
DR   STRING; 452652.KSE_09990; -.
DR   EnsemblBacteria; BAJ26835; BAJ26835; KSE_09990.
DR   KEGG; ksk:KSE_09990; -.
DR   PATRIC; fig|452652.3.peg.991; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000007076; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007076};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:BAJ26835.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007076}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  78409 MW;  36244A79F1795590 CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVVQAYA ATAGVSVETR DISLAGRIIA VFPEYLQEDQ
     RIADALAELG ELAKTPGANI IKLPNISASV PQLKAAIAEL QAQGYALPEY PDEPQTDEER
     DVRARYDKVK GSAVNPVLRE GNSDRRAPLS VKNYAKTHPH RMGAWTADSK TNVATMGEND
     FASTEKSAVI AADGALRIEL VAEDGTVTVL REKVPVLAGE VVDASVMRAA ALNEFLAAQV
     ARAKAEGVLF SVHLKATMMK VSDPILFGHV VRAFFPKTFA AFGADLAAAG LNPNNGLGGI
     LAGLDKLANG AEIKASFDAE LADGPALAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGQEAD TLAVIPDSSY AGVYQATIDD CRTNGALDPA TIGSVPNVGL MAQAAEEYGS
     HDKTFEIPAA GTVRLVDADG ETVLEQAVAP GDIFRACQTK DLPIQDWVKL AVTRARATGD
     PAVFWLDAER AHDAVLIEKV KAYLPEHDTE GLDIRILTPV EATKLSLERI RRGENTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKENYLRWD
     SLGEFFALAA SFEHLAATTG NAGAQVLADT LDRATGTFLN EDKSPSRRLG GIDNRGSHFY
     LALYWAQELA AQTEDAALAA AFAPLAQTLT EQEQVIVDEL IAVQGQPAEL GGYYQPDPAK
     AAAVMRPSKT LNDALGSLA
//
DBGET integrated database retrieval system