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Database: UniProt/TrEMBL
Entry: E4RYK6_LEAB4
LinkDB: E4RYK6_LEAB4
Original site: E4RYK6_LEAB4 
ID   E4RYK6_LEAB4            Unreviewed;       916 AA.
AC   E4RYK6;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   28-FEB-2018, entry version 41.
DE   SubName: Full=2-oxoglutarate dehydrogenase, E1 subunit {ECO:0000313|EMBL:ADQ19136.1};
DE            EC=1.2.4.2 {ECO:0000313|EMBL:ADQ19136.1};
GN   OrderedLocusNames=Lbys_3488 {ECO:0000313|EMBL:ADQ19136.1};
OS   Leadbetterella byssophila (strain DSM 17132 / KACC 11308 / 4M15).
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Cytophagaceae;
OC   Leadbetterella.
OX   NCBI_TaxID=649349 {ECO:0000313|EMBL:ADQ19136.1, ECO:0000313|Proteomes:UP000007435};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17132;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ivanova N., Teshima H., Brettin T., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Tindall B., Pomrenke H.G., Brambilla E., Klenk H.-P.,
RA   Eisen J.A.;
RT   "The complete genome of Leadbetterella byssophila DSM 17132.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADQ19136.1, ECO:0000313|Proteomes:UP000007435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17132 / KACC 11308 / 4M15
RC   {ECO:0000313|Proteomes:UP000007435};
RX   PubMed=21475582; DOI=10.4056/sigs.1413518;
RA   Abt B., Teshima H., Lucas S., Lapidus A., Del Rio T.G., Nolan M.,
RA   Tice H., Cheng J.F., Pitluck S., Liolios K., Pagani I., Ivanova N.,
RA   Mavromatis K., Pati A., Tapia R., Han C., Goodwin L., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Goker M., Tindall B.J., Detter J.C., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT   "Complete genome sequence of Leadbetterella byssophila type strain
RT   (4M15).";
RL   Stand. Genomic Sci. 4:2-12(2011).
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DR   EMBL; CP002305; ADQ19136.1; -; Genomic_DNA.
DR   RefSeq; WP_013410160.1; NC_014655.1.
DR   ProteinModelPortal; E4RYK6; -.
DR   STRING; 649349.Lbys_3488; -.
DR   EnsemblBacteria; ADQ19136; ADQ19136; Lbys_3488.
DR   KEGG; lby:Lbys_3488; -.
DR   eggNOG; ENOG4105C7P; Bacteria.
DR   eggNOG; COG0567; LUCA.
DR   HOGENOM; HOG000259586; -.
DR   KO; K00164; -.
DR   OMA; IDMVCYR; -.
DR   OrthoDB; POG091H03SK; -.
DR   BioCyc; LBYS649349:G1GOY-3513-MONOMER; -.
DR   Proteomes; UP000007435; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007435};
KW   Oxidoreductase {ECO:0000313|EMBL:ADQ19136.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007435}.
FT   DOMAIN      582    775       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
SQ   SEQUENCE   916 AA;  104607 MW;  ABE74D2A9E1A4077 CRC64;
     MDQFSYIANG DVSAIEALYK QYLQDPSSVD KSWQFFFKGY EFNNTWGEGP GKAGVSSDSL
     QKEREVVHLI RGYRSRGHLL SQIDPIYSKR KYNANLDLKF FGLSEADYDT VFEAGVEVFG
     RPATLRELET FLKNVYGGKI GYEYLYIRDS KVKNWLRNKV ESDYLNYKPS KEQKLRILGN
     LNKAVAFENF LHTKFLGKKR FSLEGGESTI PALDAAIQHG AKLGVEEVVI GMAHRGRLNV
     LTNIMQKPYE QVFNEFEENV PTLEFSDGDV KYHMGYSSQV ETVEGHRVSL KLMANPSHLE
     TVDPVVLGYA RARADAHFKS EGTKYNSFDD IYDKILPIII HGDASLAGQG VVYEVNQMSN
     LPGYYVGGAI HFIINNQIGF TTDNRDARSS IYSSDVAKML DTPILHVNGD DAEAVVYAME
     LAIEFRQEFN KDIYIDMICY RKYGHNEADE PKFTQPGMYE IISKHPSPRE IYIEKLKSDG
     TITDNDARTL KEQFDNNLQD LLSKVKQNQL PYELPKLERD WAELRRSTVG DFDSSPRTGI
     SREEIELVGK ALSTVPEGFT PIKQIEKVLE ERREIFAGKK PFNWAAAELL AYGSILAEEK
     WVRMSGQDVQ RGTFSHRHAI LHDVKTYEAY NNLAHIKPNQ GKFEIYNSLL SEYAVMGFEY
     GYALANPNAL VIWEAQFGDF ANGAQIMIDQ FVVAAESKWN LMNGLVLLLP HGYEGQGPEH
     SNARPERFLQ LAGEYNIYVC NCTTPANFFH MLRRQLALPF RKPCVHMSPK SMLRHPMAIS
     DISEFETGTS FREVIGDADA DPKKVKRVLL CTGKIYYDLL KRKMDSKRED IAIIRLEQLY
     PLPKVQLLAE LEKYAGAEQI WVQEEPLNMG YWSYLRREYP EANWDVISRK ISASPATGYT
     KNHNEFQNKI LDKAFE
//
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