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Database: UniProt/TrEMBL
Entry: E4T9U1_RIEAD
LinkDB: E4T9U1_RIEAD
Original site: E4T9U1_RIEAD 
ID   E4T9U1_RIEAD            Unreviewed;       264 AA.
AC   E4T9U1;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   26-NOV-2014, entry version 30.
DE   RecName: Full=Thymidylate synthase {ECO:0000256|HAMAP-Rule:MF_00008, ECO:0000256|SAAS:SAAS00013229};
DE            Short=TS {ECO:0000256|HAMAP-Rule:MF_00008};
DE            Short=TSase {ECO:0000256|HAMAP-Rule:MF_00008};
DE            EC=2.1.1.45 {ECO:0000256|HAMAP-Rule:MF_00008, ECO:0000256|SAAS:SAAS00013228};
GN   Name=thyA {ECO:0000256|HAMAP-Rule:MF_00008};
GN   OrderedLocusNames=Riean_0607 {ECO:0000313|EMBL:ADQ81772.1};
GN   ORFNames=RA0C_0840 {ECO:0000313|EMBL:AFD55782.1};
OS   Riemerella anatipestifer (strain ATCC 11845 / DSM 15868 / JCM 9532 /
OS   NCTC 11014).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Riemerella.
OX   NCBI_TaxID=693978 {ECO:0000313|EMBL:ADQ81772.1, ECO:0000313|Proteomes:UP000010093};
RN   [1] {ECO:0000313|EMBL:ADQ81772.1, ECO:0000313|Proteomes:UP000008719}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11845 / DSM 15868 / JCM 9532 / NCTC 11014
RC   {ECO:0000313|Proteomes:UP000008719}, and DSM 15868
RC   {ECO:0000313|EMBL:ADQ81772.1};
RX   PubMed=21677851; DOI=10.4056/sigs.1553862;
RA   Mavromatis K., Lu M., Misra M., Lapidus A., Nolan M., Lucas S.,
RA   Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA   Pitluck S., Liolios K., Pagani I., Ivanova N., Mikhailova N., Pati A.,
RA   Chen A., Palaniappan K., Land M., Hauser L., Jeffries C.D.,
RA   Detter J.C., Brambilla E.M., Rohde M., Goker M., Gronow S., Woyke T.,
RA   Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P.,
RA   Kyrpides N.C.;
RT   "Complete genome sequence of Riemerella anatipestifer type strain
RT   (ATCC 11845).";
RL   Stand. Genomic Sci. 4:144-153(2011).
RN   [2] {ECO:0000313|EMBL:AFD55782.1, ECO:0000313|Proteomes:UP000010093}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11845 {ECO:0000313|EMBL:AFD55782.1};
RX   PubMed=22628503; DOI=10.1128/JB.00366-12;
RA   Wang X., Zhu D., Wang M., Cheng A., Jia R., Zhou Y., Chen Z., Luo Q.,
RA   Liu F., Wang Y., Chen X.Y.;
RT   "Complete genome sequence of Riemerella anatipestifer reference
RT   strain.";
RL   J. Bacteriol. 194:3270-3271(2012).
RN   [3] {ECO:0000313|EMBL:AFD55782.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 11845 {ECO:0000313|EMBL:AFD55782.1};
RA   Cheng A.-C., Wang M.-S., Zhu D.-K., Wang X.-J.;
RT   "Riemerella anatipestifer ATCC 11845 Complete Genome.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Provides the sole de novo source of dTMP for DNA
CC       biosynthesis. {ECO:0000256|HAMAP-Rule:MF_00008}.
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP. {ECO:0000256|HAMAP-Rule:MF_00008,
CC       ECO:0000256|SAAS:SAAS00013244}.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00008, ECO:0000256|SAAS:SAAS00013251}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00008,
CC       ECO:0000256|SAAS:SAAS00013225}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00008}.
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family. Bacterial-
CC       type ThyA subfamily. {ECO:0000256|HAMAP-Rule:MF_00008}.
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DR   EMBL; CP002346; ADQ81772.1; -; Genomic_DNA.
DR   EMBL; CP003388; AFD55782.1; -; Genomic_DNA.
DR   RefSeq; WP_013446852.1; NC_017045.1.
DR   RefSeq; YP_004045278.1; NC_014738.1.
DR   RefSeq; YP_005394325.1; NC_017045.1.
DR   ProteinModelPortal; E4T9U1; -.
DR   EnsemblBacteria; ADQ81772; ADQ81772; Riean_0607.
DR   EnsemblBacteria; AFD55782; AFD55782; RA0C_0840.
DR   GeneID; 10001352; -.
DR   GeneID; 11995812; -.
DR   KEGG; rai:RA0C_0840; -.
DR   KEGG; ran:Riean_0607; -.
DR   PATRIC; 45351892; VBIRieAna155424_0612.
DR   HOGENOM; HOG000257900; -.
DR   KO; K00560; -.
DR   BioCyc; RANA693978:GHF6-622-MONOMER; -.
DR   UniPathway; UPA00575; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.572.10; -; 1.
DR   HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   InterPro; IPR020940; Thymidylate_synthase_AS.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; SSF55831; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 2.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008719,
KW   ECO:0000313|Proteomes:UP000010093};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00008};
KW   Methyltransferase {ECO:0000256|HAMAP-Rule:MF_00008,
KW   ECO:0000256|SAAS:SAAS00013255};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00008,
KW   ECO:0000256|SAAS:SAAS00013239};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00008,
KW   ECO:0000256|SAAS:SAAS00013237}.
FT   ACT_SITE    146    146       {ECO:0000256|HAMAP-Rule:MF_00008}.
SQ   SEQUENCE   264 AA;  30062 MW;  7510D72A5775F120 CRC64;
     MQNYLDLLQH ILDHGTDKTD RTGTGTRSVF GYQLRYDLSK GFPLVTTKKV HLKSIIYELL
     WFLKGDTNIK YLNDNGVSIW DEWADDNGNL GPVYGAQWRS WKGANGKVID QISEVIHQIK
     TNPDSRRLIV SAWNAAEIPN MALAPCHALF QFYVADGRLS LQLYQRSADV FLGVPFNIAS
     YALLTMMVAQ VCGLQVGEYI HSFGDVHIYN NHFEQVQKQL SREPRPLPTM KLNPSVKDLF
     DFKFEDFTLE NYHPHSGIKA PVAV
//
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