ID   E4TRW9_MARTH            Unreviewed;       264 AA.
AC   E4TRW9;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   01-MAY-2013, entry version 18.
DE   RecName: Full=Thymidylate synthase;
DE            Short=TS;
DE            Short=TSase;
DE            EC=2.1.1.45;
GN   Name=thyA; OrderedLocusNames=Ftrac_0718;
OS   Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB
OS   1408 / VKM B-1430 / H-43) (Microscilla tractuosa) (Flexibacter
OS   tractuosus).
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Flammeovirgaceae;
OC   Marivirga.
OX   NCBI_TaxID=643867;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 /
RC   H-43;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA   Chertkov O., Held B., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D.,
RA   Spring S., Schroeder M., Schneider S., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of chromosome of Marivirga tractuosa DSM 4126.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Provides the sole de novo source of dTMP for DNA
CC       biosynthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP =
CC       dihydrofolate + dTMP.
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family. Bacterial-
CC       type ThyA subfamily.
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DR   EMBL; CP002349; ADR20720.1; -; Genomic_DNA.
DR   RefSeq; YP_004052828.1; NC_014759.1.
DR   EnsemblBacteria; ADR20720; ADR20720; Ftrac_0718.
DR   GeneID; 10010846; -.
DR   KEGG; mtt:Ftrac_0718; -.
DR   PATRIC; 45214663; VBIMarTra126157_0755.
DR   HOGENOM; HOG000257899; -.
DR   KO; K00560; -.
DR   BioCyc; MTRA643867:GI2X-730-MONOMER; -.
DR   UniPathway; UPA00575; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:HAMAP.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:HAMAP.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.572.10; -; 1.
DR   HAMAP; MF_00008; Thymidy_synth_bact; 1; -.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   InterPro; IPR020940; Thymidylate_synthase_AS.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; Thymidylat_synth_C; 1.
DR   TIGRFAMs; TIGR03284; thym_sym; 2.
DR   PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Methyltransferase;
KW   Nucleotide biosynthesis; Transferase.
FT   ACT_SITE    146    146       By similarity.
SQ   SEQUENCE   264 AA;  30353 MW;  68297BF7C67FBB86 CRC64;
     MKQYHELMKH ILDKGVQKGD RTGTGTISVF GYQMRFDLSE GFPVVTTKKL HLRSIIHELL
     WFLKGETNIK YLKENGVSIW DEWADENGEL GPVYGSQWRN WPTPDGQHID QISQIIDQIK
     NTPNSRRIMV SAWNVADVPN MALPPCHALF QFYVADGKLS CQLYQRSADV FLGVPFNIAS
     YALLTMMVAQ VCDLEPGDFI HTLGDAHLYS NHLEQTELQL SREPYPLPKM KINPNVKNIF
     DFKFEDFELV DYQYHPHIKA PVAV
//