GenomeNet

Database: UniProt/TrEMBL
Entry: E4UB39_LIBSC
LinkDB: E4UB39_LIBSC
Original site: E4UB39_LIBSC 
ID   E4UB39_LIBSC            Unreviewed;       231 AA.
AC   E4UB39;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   09-JUL-2014, entry version 24.
DE   RecName: Full=Orotate phosphoribosyltransferase;
DE            Short=OPRT;
DE            Short=OPRTase;
DE            EC=2.4.2.10;
GN   Name=pyrE; OrderedLocusNames=CKC_03845;
OS   Liberibacter solanacearum (strain CLso-ZC1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Candidatus Liberibacter.
OX   NCBI_TaxID=658172;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLso-ZC1;
RA   Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y.,
RA   Zhou L., Glynn J.;
RT   "Complete genome sequence of Candidatus Liberibacter solanacearum
RT   CLso-ZC1.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CLso-ZC1;
RA   Lin H., Doddapaneni H.V., Lou B., Civerolo E.L., Chen C., Duan Y.,
RA   Zhou L., Glynn J.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from
CC       5-phosphoribose 1-diphosphate to orotate, leading to the formation
CC       of orotidine monophosphate (OMP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Orotidine 5'-phosphate + diphosphate = orotate
CC       + 5-phospho-alpha-D-ribose 1-diphosphate.
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from orotate: step 1/2.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine
CC       phosphoribosyltransferase family. PyrE subfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP002371; ADR52518.1; -; Genomic_DNA.
DR   RefSeq; YP_004063006.1; NC_014774.1.
DR   ProteinModelPortal; E4UB39; -.
DR   EnsemblBacteria; ADR52518; ADR52518; CKC_03845.
DR   GeneID; 10034142; -.
DR   KEGG; lso:CKC_03845; -.
DR   PATRIC; 45199003; VBICanLib97138_0768.
DR   HOGENOM; HOG000037975; -.
DR   KO; K00762; -.
DR   BioCyc; LSOL658172:GHHM-801-MONOMER; -.
DR   UniPathway; UPA00070; UER00119.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_01208; PyrE; 1.
DR   InterPro; IPR023031; OPRT.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycosyltransferase; Magnesium;
KW   Pyrimidine biosynthesis; Transferase.
FT   REGION      133    141       5-phosphoribose 1-diphosphate binding (By
FT                                similarity).
FT   BINDING     107    107       5-phosphoribose 1-diphosphate; shared
FT                                with dimeric partner (By
FT                                similarity){EA3}.
FT   BINDING     108    108       5-phosphoribose 1-diphosphate (By
FT                                similarity){EA3}.
FT   BINDING     111    111       5-phosphoribose 1-diphosphate; shared
FT                                with dimeric partner (By
FT                                similarity){EA3}.
FT   BINDING     113    113       5-phosphoribose 1-diphosphate; shared
FT                                with dimeric partner (By
FT                                similarity){EA3}.
FT   BINDING     137    137       Orotate (By similarity){EA3}.
SQ   SEQUENCE   231 AA;  26173 MW;  4EF4F3073C3224D7 CRC64;
     MIFSDFPEPK FMAELVAKML FEIKAVNFSP EKPYRLTSGI VSPVYIDCRK LISFARVRST
     IMNFATTIVL RNIGFESIDI IAGGETAGIP FAAFLAERLS LPMIYVRKKT KNHGRKSQIE
     GHIFKGARIL IIEDLITLGG SMVDFVQVIR KSGGVVKNGI GLFFYDIFPD ITVRLRENDI
     NLHYLATWND IMKVATNLKI FNQDILDEVQ YFLDNPMIWS EKNGGIGKIE K
//
DBGET integrated database retrieval system