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Database: UniProt/TrEMBL
Entry: E4WJP9_RHOE1
LinkDB: E4WJP9_RHOE1
Original site: E4WJP9_RHOE1 
ID   E4WJP9_RHOE1            Unreviewed;       343 AA.
AC   E4WJP9;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   19-FEB-2014, entry version 19.
DE   RecName: Full=6-phosphofructokinase;
DE            Short=Phosphofructokinase;
DE            EC=2.7.1.11;
DE   AltName: Full=Phosphohexokinase;
GN   Name=pfkA; OrderedLocusNames=REQ_31560;
OS   Rhodococcus equi (strain 103S) (Corynebacterium equi).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=685727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=103S;
RX   PubMed=20941392; DOI=10.1371/journal.pgen.1001145;
RA   Letek M., Gonzalez P., Macarthur I., Rodriguez H., Freeman T.C.,
RA   Valero-Rello A., Blanco M., Buckley T., Cherevach I., Fahey R.,
RA   Hapeshi A., Holdstock J., Leadon D., Navas J., Ocampo A., Quail M.A.,
RA   Sanders M., Scortti M.M., Prescott J.F., Fogarty U., Meijer W.G.,
RA   Parkhill J., Bentley S.D., Vazquez-Boland J.A.;
RT   "The genome of a pathogenic rhodococcus: cooptive virulence
RT   underpinned by key gene acquisitions.";
RL   PLoS Genet. 6:E1001145-E1001145(2010).
CC   -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC       fructose 1,6-bisphosphate.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 3/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the phosphofructokinase family.
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DR   EMBL; FN563149; CBH49157.1; -; Genomic_DNA.
DR   RefSeq; YP_004007837.1; NC_014659.1.
DR   ProteinModelPortal; E4WJP9; -.
DR   EnsemblBacteria; CBH49157; CBH49157; REQ_31560.
DR   GeneID; 9967049; -.
DR   KEGG; req:REQ_31560; -.
DR   PATRIC; 42663775; VBIRhoEqu141084_3153.
DR   HOGENOM; HOG000248869; -.
DR   KO; K00850; -.
DR   OMA; WVGLMED; -.
DR   BioCyc; REQU685727:GHKP-3047-MONOMER; -.
DR   UniPathway; UPA00109; UER00182.
DR   GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046835; P:carbohydrate phosphorylation; IEA:GOC.
DR   GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00339; Phosphofructokinase; 1.
DR   InterPro; IPR012003; ATP_PFK_prok.
DR   InterPro; IPR012829; PFK.
DR   InterPro; IPR022953; Phosphofructokinase.
DR   InterPro; IPR015912; Phosphofructokinase_CS.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   Pfam; PF00365; PFK; 1.
DR   PIRSF; PIRSF000532; ATP_PFK_prok; 1.
DR   PRINTS; PR00476; PHFRCTKINASE.
DR   SUPFAM; SSF53784; SSF53784; 1.
DR   TIGRFAMs; TIGR02483; PFK_mixed; 1.
DR   PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase;
KW   Nucleotide-binding; Transferase.
FT   NP_BIND      20     24       ATP (By similarity).
FT   NP_BIND     155    159       ATP (By similarity).
FT   NP_BIND     172    188       ATP (By similarity).
FT   ACT_SITE    128    128       Proton acceptor (By similarity).
FT   BINDING     163    163       Substrate (By similarity).
FT   BINDING     267    267       Substrate (By similarity).
FT   BINDING     273    273       Substrate (By similarity).
FT   BINDING     276    276       Substrate (By similarity).
SQ   SEQUENCE   343 AA;  37032 MW;  7A388524966ED249 CRC64;
     MRIGILTGGG DCPGLNAVIR AVVRTADSRY GSTVVGFRDG WRGLLEDRKV QMRNEDRIDR
     ILARGGTILG TARVNPQKLH DGLDRIKQTL DDNGIDVLIP IGGEGTLTAG SWLAESGVPV
     VGVPKTIDND IDCTDVTFGF DTALTIATEA IDRLHTTAES HQRVMLVEVM GRHAGWIALQ
     SGMASGAHLT LVPEVPFDVD EVCALVKKRF QRGDSHFICV VAEGAAPDPE SMTLREGGID
     EFGHKIFTGV AQQLAVEIER RIGKEVRTTV LGHVQRGGTP TPYDRVLATR FGVHATDAAH
     NGQFGQMVAL HGTNIELVPL SEATKQLKTV PVERYREAAA FFG
//
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