ID E4WJP9_RHOE1 Unreviewed; 343 AA.
AC E4WJP9;
DT 08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT 08-FEB-2011, sequence version 1.
DT 01-MAY-2013, entry version 16.
DE RecName: Full=6-phosphofructokinase;
DE Short=Phosphofructokinase;
DE EC=2.7.1.11;
DE AltName: Full=Phosphohexokinase;
GN Name=pfkA; OrderedLocusNames=REQ_31560;
OS Rhodococcus equi (strain 103S) (Corynebacterium equi).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Nocardiaceae; Rhodococcus.
OX NCBI_TaxID=685727;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=103S;
RX PubMed=20941392; DOI=10.1371/journal.pgen.1001145;
RA Letek M., Gonzalez P., Macarthur I., Rodriguez H., Freeman T.C.,
RA Valero-Rello A., Blanco M., Buckley T., Cherevach I., Fahey R.,
RA Hapeshi A., Holdstock J., Leadon D., Navas J., Ocampo A., Quail M.A.,
RA Sanders M., Scortti M.M., Prescott J.F., Fogarty U., Meijer W.G.,
RA Parkhill J., Bentley S.D., Vazquez-Boland J.A.;
RT "The genome of a pathogenic rhodococcus: cooptive virulence
RT underpinned by key gene acquisitions.";
RL PLoS Genet. 6:E1001145-E1001145(2010).
CC -!- CATALYTIC ACTIVITY: ATP + D-fructose 6-phosphate = ADP + D-
CC fructose 1,6-bisphosphate.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 3/4.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the phosphofructokinase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; FN563149; CBH49157.1; -; Genomic_DNA.
DR RefSeq; YP_004007837.1; NC_014659.1.
DR ProteinModelPortal; E4WJP9; -.
DR EnsemblBacteria; CBH49157; CBH49157; REQ_31560.
DR GeneID; 9967049; -.
DR KEGG; req:REQ_31560; -.
DR PATRIC; 42663775; VBIRhoEqu141084_3153.
DR HOGENOM; HOG000248869; -.
DR KO; K00850; -.
DR OMA; SAQANIC; -.
DR BioCyc; REQU685727:GHKP-4259-MONOMER; -.
DR UniPathway; UPA00109; UER00182.
DR GO; GO:0005945; C:6-phosphofructokinase complex; IEA:InterPro.
DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:HAMAP.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR HAMAP; MF_00339; Phosphofructokinase; 1; -.
DR InterPro; IPR012003; ATP_PFK_prok.
DR InterPro; IPR012829; PFK.
DR InterPro; IPR022953; Phosphofructokinase.
DR InterPro; IPR015912; Phosphofructokinase_CS.
DR InterPro; IPR000023; Phosphofructokinase_dom.
DR Pfam; PF00365; PFK; 1.
DR PIRSF; PIRSF000532; ATP_PFK_prok; 1.
DR PRINTS; PR00476; PHFRCTKINASE.
DR SUPFAM; SSF53784; Ppfruckinase; 1.
DR TIGRFAMs; TIGR02483; PFK_mixed; 1.
DR PROSITE; PS00433; PHOSPHOFRUCTOKINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Glycolysis; Kinase;
KW Nucleotide-binding; Transferase.
FT NP_BIND 20 24 ATP (By similarity).
FT NP_BIND 155 159 ATP (By similarity).
FT NP_BIND 172 188 ATP (By similarity).
FT ACT_SITE 128 128 Proton acceptor (By similarity).
FT BINDING 163 163 Substrate (By similarity).
FT BINDING 267 267 Substrate (By similarity).
FT BINDING 273 273 Substrate (By similarity).
FT BINDING 276 276 Substrate (By similarity).
SQ SEQUENCE 343 AA; 37032 MW; 7A388524966ED249 CRC64;
MRIGILTGGG DCPGLNAVIR AVVRTADSRY GSTVVGFRDG WRGLLEDRKV QMRNEDRIDR
ILARGGTILG TARVNPQKLH DGLDRIKQTL DDNGIDVLIP IGGEGTLTAG SWLAESGVPV
VGVPKTIDND IDCTDVTFGF DTALTIATEA IDRLHTTAES HQRVMLVEVM GRHAGWIALQ
SGMASGAHLT LVPEVPFDVD EVCALVKKRF QRGDSHFICV VAEGAAPDPE SMTLREGGID
EFGHKIFTGV AQQLAVEIER RIGKEVRTTV LGHVQRGGTP TPYDRVLATR FGVHATDAAH
NGQFGQMVAL HGTNIELVPL SEATKQLKTV PVERYREAAA FFG
//
