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Database: UniProt/TrEMBL
Entry: E6R5L9_CRYGW
LinkDB: E6R5L9_CRYGW
Original site: E6R5L9_CRYGW 
ID   E6R5L9_CRYGW            Unreviewed;       510 AA.
AC   E6R5L9;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   22-NOV-2017, entry version 44.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   OrderedLocusNames=CGB_D1760C {ECO:0000313|EMBL:ADV21566.1};
OS   Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS   (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV21566.1, ECO:0000313|Proteomes:UP000007805};
RN   [1] {ECO:0000313|EMBL:ADV21566.1, ECO:0000313|Proteomes:UP000007805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T.,
RA   Sawkins J., McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q.,
RA   Bartlett K., Li W., Wang X., Heitman J., Stajich J.E., Fraser J.A.,
RA   Meyer W., Carter D., Schein J., Krzywinski M., Kwon-Chung K.J.,
RA   Varma A., Wang J., Brunham R., Fyfe M., Ouellette B.F., Siddiqui A.,
RA   Marra M., Jones S., Holt R., Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WM276;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T.,
RA   Sawkins J., McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q.,
RA   Bartlett K., Li W., Wang X., Heitman J., Stajich J.E., Fraser J.A.,
RA   Meyer W., Carter D., Schein J., Krzywinski M., Kwong-Chung K.J.,
RA   Varma A., Wang J., Brunham R., Fyfe M., Ouellette B.F.F., Siddiqui A.,
RA   Marra M., Jones S., Holt R., Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 0:0-0(2011).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
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DR   EMBL; CP000289; ADV21566.1; -; Genomic_DNA.
DR   RefSeq; XP_003193353.1; XM_003193305.1.
DR   ProteinModelPortal; E6R5L9; -.
DR   STRING; 367775.XP_003193353.1; -.
DR   EnsemblFungi; ADV21566; ADV21566; CGB_D1760C.
DR   GeneID; 10191033; -.
DR   KEGG; cgi:CGB_D1760C; -.
DR   EuPathDB; FungiDB:CGB_D1760C; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   eggNOG; COG0123; LUCA.
DR   KO; K06067; -.
DR   OrthoDB; EOG092C386A; -.
DR   Proteomes; UP000007805; Chromosome D.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 2.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007805};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007805};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290}.
FT   DOMAIN       31    445       Hist_deacetyl. {ECO:0000259|Pfam:
FT                                PF00850}.
SQ   SEQUENCE   510 AA;  56672 MW;  261498BDA0F45A01 CRC64;
     MAPDTRFTNR SKIRVSYLWS PSLQRLSDDL PSNVGRSSMV HDLIKSLGLL DFEELKGSLS
     GRGKKGDGDG ESEDDDDNEG DRDEIQNEDK QEADGESQRT PVSPTELSTH AQDEKATVVL
     PDPSLGTKTC LIRYHDRSYI ERLLKAHTDE DPNDPTHLPS SPLSSTSSPR RAKIARTDPY
     NLSHDNPVFP SLSSYISHIA AATSTACRLL ATDETDWAVC WDGGRHHAKR KEAGGFCYVN
     DLVLGGLLLA REGRIPLQLK EGEDVKRQRT RAPRIFYLDM DLHYSDGVSA AFHSPTVYPY
     PMEEGVNPPK PPNVLTLSVH HSSPIFFPPP TPLSLLPSPG TESPFSLSIP LSAYPSRQTY
     AKVFNQCIQP IREAWDPDYV ILQLGTDGLP GDRVGQYGNW SVAGEGGIKW VVERVKEWGK
     KVCVTGGGGY RHDNAARAWA EVMGVLLDRD FEEDMPIPHH DHFEQYAPSF TLQVPDSHMR
     DENKPEDLEK AAEVFNVLAE RIKVIVDANS
//
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