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Database: UniProt/TrEMBL
Entry: E6RDT0_CRYGW
LinkDB: E6RDT0_CRYGW
Original site: E6RDT0_CRYGW 
ID   E6RDT0_CRYGW            Unreviewed;      1073 AA.
AC   E6RDT0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   25-OCT-2017, entry version 44.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   OrderedLocusNames=CGB_K3320W {ECO:0000313|EMBL:ADV24969.1};
OS   Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS   (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=367775 {ECO:0000313|EMBL:ADV24969.1, ECO:0000313|Proteomes:UP000007805};
RN   [1] {ECO:0000313|EMBL:ADV24969.1, ECO:0000313|Proteomes:UP000007805}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM276 / ATCC MYA-4071 {ECO:0000313|Proteomes:UP000007805};
RX   PubMed=21304167; DOI=10.1128/mBio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T.,
RA   Sawkins J., McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q.,
RA   Bartlett K., Li W., Wang X., Heitman J., Stajich J.E., Fraser J.A.,
RA   Meyer W., Carter D., Schein J., Krzywinski M., Kwon-Chung K.J.,
RA   Varma A., Wang J., Brunham R., Fyfe M., Ouellette B.F., Siddiqui A.,
RA   Marra M., Jones S., Holt R., Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WM276;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T.,
RA   Sawkins J., McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q.,
RA   Bartlett K., Li W., Wang X., Heitman J., Stajich J.E., Fraser J.A.,
RA   Meyer W., Carter D., Schein J., Krzywinski M., Kwong-Chung K.J.,
RA   Varma A., Wang J., Brunham R., Fyfe M., Ouellette B.F.F., Siddiqui A.,
RA   Marra M., Jones S., Holt R., Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 0:0-0(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CP000296; ADV24969.1; -; Genomic_DNA.
DR   RefSeq; XP_003196756.1; XM_003196708.1.
DR   STRING; 367775.XP_003196756.1; -.
DR   EnsemblFungi; ADV24969; ADV24969; CGB_K3320W.
DR   GeneID; 10185288; -.
DR   KEGG; cgi:CGB_K3320W; -.
DR   EuPathDB; FungiDB:CGB_K3320W; -.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000007805; Chromosome K.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 2.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007805};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:ADV24969.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN      383    522       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      693    783       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      962   1072       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   1073 AA;  123876 MW;  C24415B1B5D3DCDD CRC64;
     MAVHAPYYHA PPPTQEINGE KPTLTAATTL ERPADCINRG QYPAFYIICG YLNRLRADAP
     HKKYELLMRI FGNWREKVGP DLYPLIRLLL PDKDRERPVY NLKESMLARC YIDILSLEKH
     SEAAQRLIKW KQPAEGSSNP TGDFAKVCYN EIKARSTVEE GQLSVEAVNM LLDKLAVGKM
     KQAEYVPILK AINMQCTAEE QEWIIRIILK DLHISIRERG VLSAFHPDAI DLYNICSDLK
     RVCWTLYDPG FRLNKNETHL ELFHSFVPQL CGRMNDTSLE NIAKAIGAPK EFIMEEKLDG
     ERIQLHMRGN GAQWFYCSRK AKDYTYLYGA HPGEGSLTRY IANAFQDNVR NIILDGEMMV
     WDPVVERYLA FGTLKSAALD HFNDETAPRP CFKVFDILFL NDHCLSRKRL SERKRLLRSG
     KIFKNIEDYK GRLEFVDEKR GKSAKDIREY LERVVETKGE GLVVKKTDVI YQTNSRGYDW
     IKVKPEYSDQ MGENLEVLVL GGWWGKGGRS GKISRLLCGL REQAFDDGTL QDFLFNRFWN
     ELFRLRVDFH KKHWKPFDRS NPPAFMKLGP VGLDDKPDVY IEPENSFVIE VKASEIVPAG
     GGYGIGFTLR FPRCKYIYYD RNSRDYELDD DWDFCGTRKL TEWADFMDLF SRPKRSYDDS
     QGPGKKKKRK VVRSKKNHIT TNFRGQKLSN IDVETSIFSD MTFYIAKGTS EYPKADLEAL
     VHKHGADFTQ AQLSDLSAIV ISPDQKSPLV RAQIRHGVNV IKPEWIFESI ARRKALPLLK
     EFLVYASEEA QEGRYYNKTL EQYDKISFVR DRTGETLFEE DGDADVEEEA MDDEDKDEID
     MEEAREAKDR RMAREDLKER ESNRSLEQKK LQEAWGLRSR ASTGGSDSEA EEIKSLKEES
     DTDSERIRRL RAIYQDEEDE ENDSHESDVG VDGDGYRLVP LNELNDKEEG FMGESPEAMH
     YDEDRIFYHL AFYIDTPENA AVNGLESSSP SLNAQERLAK IEKLLVEKGG RAVKSISDPK
     LTHIIMDDED SGRYVELTRK TALPKRKHIV TPKWVEDCVD EETLLDEDLY KPR
//
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