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Database: UniProt/TrEMBL
Entry: E6S9C5_INTC7
LinkDB: E6S9C5_INTC7
Original site: E6S9C5_INTC7 
ID   E6S9C5_INTC7            Unreviewed;       734 AA.
AC   E6S9C5;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ADU47101.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ADU47101.1};
GN   OrderedLocusNames=Intca_0556 {ECO:0000313|EMBL:ADU47101.1};
OS   Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS   NBRC 12989 / 7 KIP).
OC   Bacteria; Actinobacteria; Micrococcales; Intrasporangiaceae;
OC   Intrasporangium.
OX   NCBI_TaxID=710696 {ECO:0000313|EMBL:ADU47101.1, ECO:0000313|Proteomes:UP000008914};
RN   [1] {ECO:0000313|EMBL:ADU47101.1, ECO:0000313|Proteomes:UP000008914}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP
RC   {ECO:0000313|Proteomes:UP000008914};
RX   PubMed=21304734; DOI=10.4056/sigs.1263355;
RA   Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA   Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA   Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA   Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Intrasporangium calvum type strain (7
RT   KIP).";
RL   Stand. Genomic Sci. 3:294-303(2010).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002343; ADU47101.1; -; Genomic_DNA.
DR   RefSeq; WP_013491422.1; NC_014830.1.
DR   ProteinModelPortal; E6S9C5; -.
DR   STRING; 710696.Intca_0556; -.
DR   EnsemblBacteria; ADU47101; ADU47101; Intca_0556.
DR   KEGG; ica:Intca_0556; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   HOGENOM; HOG000240860; -.
DR   KO; K00031; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; ICAL710696:GH9U-569-MONOMER; -.
DR   Proteomes; UP000008914; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008914};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ADU47101.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008914}.
FT   REGION      125    132       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       343    343       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       541    541       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       545    545       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     138    138       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     540    540       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        248    248       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        413    413       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   734 AA;  78276 MW;  CF8F7CC4B5DAEAA9 CRC64;
     MTDSKIIYTY TDEAPALATA SLLPIVQAFA SKAGVDVETR DISLAGRILA AFGLADDALA
     ELGALAKRPE ANIIKLPNVS ASIPQLKAAV KELQDEGHAV PDYPDNPTTD EEKAARAAYD
     KIKGSAVNPV LREGNSDRRA PASVKNYARR HPHSMGAWSP DSKTNVATMD ADDFAHNEKS
     VILAQDDTLR MEHVAADGTT TVLKESLPVL AGEVVDATFM NAAALRQFLA AQVQRAKDEG
     VLFSVHLKAT MMKVSDPIMF GHAVRAFFPD VFETYAAELA SVGASPNDGL GAVLSSIEAL
     PQDKRAEIEA AFEKGFAEGP AIAMVNSDKG ISNLHVPSDI IVDASMPAMI RTSGHMWNAA
     GEEEDTLAVL PDSSYSGIYQ VVLDDCRAHG AFDPATMGSV ANVGLMAQAA EEYGSHDKTF
     EIAADGVVRV VDGSGTALLE HEVSAGDIWR ACQTKDIPVR DWVKLAVTRA RATGNPAVFW
     LDEARAHDAN LIAKVTEYLG EHDTDGLDIQ ILKPTEAIAF SLERIRRGED TISVTGNVLR
     DYLTDLFPIL ELGTSAKMLS VVPLINGGGL FETGAGGSAP KHVQQLVKEN YLRWDSLGEF
     LALAVSLEHL AGATGNAKAQ ILADTLDRAT GKVLDENRSP ARRVGQIDNR GSHFWLAVYW
     AQELAAQTED AELAGAFTDV AAQLTENADA IDAELIAVQG QPADIGGYYK PDADKVDAVM
     RPSQTFNGII ASLA
//
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