ID E6SBW1_INTC7 Unreviewed; 302 AA.
AC E6SBW1;
DT 08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT 08-MAR-2011, sequence version 1.
DT 01-MAY-2013, entry version 17.
DE RecName: Full=Methylenetetrahydrofolate reductase;
DE EC=1.5.1.20;
GN OrderedLocusNames=Intca_1959;
OS Intrasporangium calvum (strain ATCC 23552 / DSM 43043 / JCM 3097 /
OS NBRC 12989 / 7 KIP).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Micrococcineae; Intrasporangiaceae; Intrasporangium.
OX NCBI_TaxID=710696;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23552 / DSM 43043 / JCM 3097 / NBRC 12989 / 7 KIP;
RX PubMed=21304734; DOI=10.4056/sigs.1263355;
RA Del Rio T.G., Chertkov O., Yasawong M., Lucas S., Deshpande S.,
RA Cheng J.F., Detter C., Tapia R., Han C., Goodwin L., Pitluck S.,
RA Liolios K., Ivanova N., Mavromatis K., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Rohde M., Pukall R., Sikorski J., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Intrasporangium calvum type strain (7
RT KIP).";
RL Stand. Genomic Sci. 3:294-303(2010).
CC -!- CATALYTIC ACTIVITY: 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-
CC methylenetetrahydrofolate + NAD(P)H.
CC -!- COFACTOR: FAD (By similarity).
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC family.
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DR EMBL; CP002343; ADU48470.1; -; Genomic_DNA.
DR RefSeq; YP_004099197.1; NC_014830.1.
DR EnsemblBacteria; ADU48470; ADU48470; Intca_1959.
DR GeneID; 10084779; -.
DR KEGG; ica:Intca_1959; -.
DR PATRIC; 45245470; VBIIntCal153415_1999.
DR HOGENOM; HOG000246233; -.
DR KO; K00297; -.
DR BioCyc; ICAL710696:GH9U-1996-MONOMER; -.
DR UniPathway; UPA00193; -.
DR GO; GO:0005829; C:cytosol; IEA:InterPro.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR InterPro; IPR003171; Mehydrof_redctse.
DR InterPro; IPR004620; MTHF_reductase_bac.
DR Pfam; PF02219; MTHFR; 1.
DR TIGRFAMs; TIGR00676; fadh2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Complete proteome; FAD; Flavoprotein;
KW Oxidoreductase.
SQ SEQUENCE 302 AA; 32905 MW; 0788992F6A6319CB CRC64;
MAHGTASSMT RAERFTRSLA AMVKADTPTF SFEFFPPKDD AAAEQLWGAI RSLEKVSPSF
ISITYGAGGS TRDRTVRLTQ RVLEETSLTP MAHLTCVGHS VGELRQVVGH YAAAGVRNIL
ALRGDPQGGL GQPWVAHPQG LNHADELVGL IKGLGDFTVG VAAFPDGHPE SRSVEDDVET
LLRKEREGAE FAITQMVFDV DNYLRLRDEL ARRGSQLPVV PGLMPITNAR QVVRMAELAG
QPMPQAVIDR LERHRDDAEA VRREGLAIAT EAARRMLDEG APGIHFITMN RSSATLEVYG
NL
//
