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Database: UniProt/TrEMBL
Entry: E6WQ47_PSEUU
LinkDB: E6WQ47_PSEUU
Original site: E6WQ47_PSEUU 
ID   E6WQ47_PSEUU            Unreviewed;       215 AA.
AC   E6WQ47;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   19-FEB-2014, entry version 21.
DE   RecName: Full=3-isopropylmalate dehydratase small subunit;
DE            EC=4.2.1.33;
DE   AltName: Full=Alpha-IPM isomerase;
DE   AltName: Full=Isopropylmalate isomerase;
GN   Name=leuD; OrderedLocusNames=Psesu_0437;
OS   Pseudoxanthomonas suwonensis (strain 11-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Pseudoxanthomonas.
OX   NCBI_TaxID=743721;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=11-1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Siebers A.K.,
RA   Allgaier M., Thelen M.P., Hugenholtz P., Gladden J., Woyke T.;
RT   "Complete sequence of Pseudoxanthomonas suwonensis 11-1.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the isomerization between 2-isopropylmalate
CC       and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-
CC       isopropylmalate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-
CC       leucine from 3-methyl-2-oxobutanoate: step 2/4.
CC   -!- SUBUNIT: Heterodimer of LeuC and LeuD (By similarity).
CC   -!- SIMILARITY: Belongs to the LeuD family. LeuD type 1 subfamily.
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DR   EMBL; CP002446; ADV26296.1; -; Genomic_DNA.
DR   RefSeq; YP_004145527.1; NC_014924.1.
DR   EnsemblBacteria; ADV26296; ADV26296; Psesu_0437.
DR   GeneID; 10121979; -.
DR   KEGG; psu:Psesu_0437; -.
DR   PATRIC; 45334630; VBIPseSuw172708_0454.
DR   HOGENOM; HOG000222939; -.
DR   KO; K01704; -.
DR   OMA; AFTTHTG; -.
DR   BioCyc; PSUW743721:GH68-439-MONOMER; -.
DR   UniPathway; UPA00048; UER00071.
DR   GO; GO:0009316; C:3-isopropylmalate dehydratase complex; IEA:InterPro.
DR   GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.19.10; -; 1.
DR   HAMAP; MF_01031; LeuD_type1; 1.
DR   InterPro; IPR004431; 3-IsopropMal_deHydase_ssu.
DR   InterPro; IPR015937; Acoase/IPM_deHydtase.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   PANTHER; PTHR11670; PTHR11670; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   SUPFAM; SSF52016; SSF52016; 1.
DR   TIGRFAMs; TIGR00171; leuD; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Leucine biosynthesis; Lyase.
SQ   SEQUENCE   215 AA;  23961 MW;  2B67338699B86F8D CRC64;
     MKAFTTHTGL VAPLDRANVD TDQIIPKQFL KSIKRTGFGP NLFDEWRYLD VGQPGEDSSR
     RPVNPDFVLN FPRYQGASVL LARENFGCGS SREHAPWALD EYGFRAIIAP SFADIFFNNS
     FKNGLLPIVL EDKEVDALFA QCEATEGYTL TVDLAAQTVT RPDGVQYGFE IDAFRKHCLL
     NGLDDIGLTL QEKDAITAFE ARHRAAQPWL FNAGA
//
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