ID E8R2A0_ISOPI Unreviewed; 332 AA.
AC E8R2A0;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 01-MAY-2013, entry version 16.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein;
GN OrderedLocusNames=Isop_2965;
OS Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B).
OC Bacteria; Planctomycetes; Planctomycetia; Planctomycetales;
OC Planctomycetaceae; Isosphaera.
OX NCBI_TaxID=575540;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43644;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders E.,
RA Brettin T., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Eisen J.A.;
RT "The complete sequence of chromosome of Isophaera pallida ATCC
RT 43644.";
RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43644 / DSM 9630 / IS1B;
RX PubMed=21475588; DOI=10.4056/sigs.1533840;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Goker M., Cleland D., Saunders E., Lapidus A., Nolan M., Lucas S.,
RA Hammon N., Deshpande S., Cheng J.F., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Pagani I., Ivanova N., Mavromatis K., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Beck B., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Isosphaera pallida type strain (IS1B).";
RL Stand. Genomic Sci. 4:63-71(2011).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family.
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DR EMBL; CP002353; ADV63530.1; -; Genomic_DNA.
DR RefSeq; YP_004180079.1; NC_014962.1.
DR ProteinModelPortal; E8R2A0; -.
DR EnsemblBacteria; ADV63530; ADV63530; Isop_2965.
DR GeneID; 10157108; -.
DR KEGG; ipa:Isop_2965; -.
DR PATRIC; 46960702; VBIIsoPal14453_3821.
DR HOGENOM; HOG000136695; -.
DR KO; K03778; -.
DR BioCyc; IPAL575540:GI5T-3009-MONOMER; -.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.50.720; -; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_2_OHA_DH_NAD-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Complete proteome; Oxidoreductase.
SQ SEQUENCE 332 AA; 35953 MW; ED0551F567E2715E CRC64;
MKVAVFGTKR YDREYLERFN AETGAGHELI FREERLSEAT VASASGCAAV CVFVNDDVSA
NVLESLAALG IKGVALRCAG FNNVDLKTAQ RLGMTVARVP AYSPHAVAEH AVALILTLNR
KTHRAFNRVR EGNFELQGLL GFDLHGKTVG TIGTGQIGLI FGRILHHGFG CRWLASDPKP
SDLARASGAE FVELDHLYAE SDIISLHCPL TPQTHHLINT DSIAKMKRGV MLINTSRGAV
VNTRAVIQGL KSGIIGALGL DVYEEEADVF FENLSDQVLQ DDVLARLLSF PNVLVTSHQA
YFTHEAMEAI ARVTLANLTA FETGTPSGNE LV
//
