ID E8RSP3_ASTEC Unreviewed; 212 AA.
AC E8RSP3;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 03-APR-2013, entry version 14.
DE RecName: Full=Thymidylate kinase;
DE EC=2.7.4.9;
DE AltName: Full=dTMP kinase;
GN Name=tmk; OrderedLocusNames=Astex_2877;
OS Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724 / VKM B-1370 /
OS CB 48).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Asticcacaulis.
OX NCBI_TaxID=573065;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15261 / DSM 4724 / VKM B-1370 / CB 48;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Teshima H., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N.,
RA Ovchinnikova G., Brun Y.V., Woyke T.;
RT "Complete sequence of chromosome 2 of Asticcacaulis excentricus CB
RT 48.";
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC salvage pathways of dTTP synthesis (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR EMBL; CP002396; ADU14514.1; -; Genomic_DNA.
DR RefSeq; YP_004088665.1; NC_014817.1.
DR EnsemblBacteria; ADU14514; ADU14514; Astex_2877.
DR GeneID; 10054475; -.
DR KEGG; aex:Astex_2877; -.
DR PATRIC; 45153711; VBIAstExc23432_2817.
DR HOGENOM; HOG000229078; -.
DR KO; K00943; -.
DR BioCyc; AEXC573065:GJ7A-2925-MONOMER; -.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR10344; PTHR10344; 1.
DR TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW Nucleotide-binding; Transferase.
FT NP_BIND 10 17 ATP (By similarity).
SQ SEQUENCE 212 AA; 23233 MW; 2DEF695583E8A166 CRC64;
MTGRFITFEG GEGAGKSTQV KALVAHLREL ALEVVQTREP GGSSGAEALR DLLVTGEAGR
WSPMSETLMM YAARANHLEQ VIRPALERGA WIVCDRFSDS TRAYQGAGGG VTPELIESID
AAVVADTQPD LVIVMDMPPE AGLKRALARG DAENRFESKG LAFHERLREG FRRRAAAHPE
RYRLIDADRS IEDIKADVWR VVSGRFAELK VS
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