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Database: UniProt/TrEMBL
Entry: E8WEJ9_STRFA
LinkDB: E8WEJ9_STRFA
Original site: E8WEJ9_STRFA 
ID   E8WEJ9_STRFA            Unreviewed;       739 AA.
AC   E8WEJ9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-JUL-2017, entry version 41.
DE   SubName: Full=Isocitrate dehydrogenase, NADP-dependent {ECO:0000313|EMBL:ADW02399.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:ADW02399.1};
GN   OrderedLocusNames=Sfla_0943 {ECO:0000313|EMBL:ADW02399.1};
OS   Streptomyces pratensis (strain ATCC 33331 / IAF-45CD).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=591167 {ECO:0000313|EMBL:ADW02399.1, ECO:0000313|Proteomes:UP000002066};
RN   [1] {ECO:0000313|EMBL:ADW02399.1, ECO:0000313|Proteomes:UP000002066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33331 / DSM 40990 / IAF-45CD
RC   {ECO:0000313|Proteomes:UP000002066};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I.,
RA   Brumm P., Mead D., Woyke T.;
RT   "Complete sequence of chromosome of Streptomyces flavogriseus ATCC
RT   33331.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP002475; ADW02399.1; -; Genomic_DNA.
DR   RefSeq; WP_014153074.1; NC_016114.1.
DR   STRING; 591167.Sfla_0943; -.
DR   EnsemblBacteria; ADW02399; ADW02399; Sfla_0943.
DR   KEGG; sfa:Sfla_0943; -.
DR   PATRIC; fig|591167.6.peg.963; -.
DR   eggNOG; ENOG4105E9K; Bacteria.
DR   eggNOG; COG2838; LUCA.
DR   KO; K00031; -.
DR   OMA; RDSGKMW; -.
DR   OrthoDB; POG091H0B3N; -.
DR   BioCyc; SPRA591167:G12Y5-919-MONOMER; -.
DR   Proteomes; UP000002066; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002066};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:ADW02399.1}.
FT   REGION      132    139       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       348    348       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       546    546       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       550    550       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     145    145       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     545    545       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        255    255       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        418    418       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   739 AA;  78978 MW;  8C62C4F70A584A9D CRC64;
     MTDSTIIYTH TDEAPALATY SFLPVIEAYA STAGVTVERR DISLAGRIIA GFPERLEAGQ
     RIDDALAELG ELARTPGANI IKLPNISASI PQLKAAIAEL QAQGYALPDY PDDPRTDEDK
     DVRARYDKVK GSAVNPVLRE GNSDRRAPAS VKNYAKAHPH RMGAWSADSK TNVATMGVDD
     FRSTEKSVVI GEAGSLRIEL AGDDGTTTVL RESVPVLAGE VVDAAVMRVA ALREFFTAQV
     ARAKAEDVLF SVHLKATMMK VSDPIIFGHV VRAFFPNTFA KYGDVLAAAG LTPNDGLGGI
     LKGLDSVDAG AEIKASFEAE LAEGPALAMV DSDKGITNLH VPSDVIVDAS MPAMIRTSGH
     MWGPDGNEAD TIAVLPDSSY AGVYQVVIDD CRANGAFDPS TMGSVPNVGL MAQKAEEYGS
     HDKTFEVPTT GTVRVVDGKG DVLLEQAVGA GDIFRMCQTK DLPIQDWVKL AVTRARATGN
     PAVFWLDEGR AHDANLIAKV NTYLAEHDTD GLDISIRTPE EATAFSLERI RRGEDTISVT
     GNVLRDYLTD LFPILELGTS AKMLSVVPLM NGGGLFETGA GGSAPKHVQQ LVKEDYLRWD
     SLGEFLALAV SFEHLATTTG NARARVLGDT LDRATGTFLN EDKSPSRKLG GIDNRGSHFY
     LALYWAQELA RQTDDAALAE AFGPLAKTLS EQERTIVDEL IAVQGKPADI GGYYQPDPAK
     AEAVMRPSAT FNKAIATLG
//
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