ID E8XZT2_RAHSY Unreviewed; 307 AA.
AC E8XZT2;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 01-MAY-2013, entry version 20.
DE RecName: Full=2-dehydropantoate 2-reductase;
DE EC=1.1.1.169;
DE Flags: Precursor;
GN OrderedLocusNames=Rahaq_4763;
OS Rahnella sp. (strain Y9602).
OG Plasmid pRAHAQ01.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Rahnella.
OX NCBI_TaxID=741091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y9602;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA Pitluck S., Lu M., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Sobecky P.A.,
RA Martinez R.J., Woyke T.;
RT "Complete sequence of plasmid1 of Rahnella sp. Y9602.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the NADPH-dependent reduction of ketopantoate
CC into pantoic acid (By similarity).
CC -!- CATALYTIC ACTIVITY: (R)-pantoate + NADP(+) = 2-dehydropantoate +
CC NADPH.
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis;
CC (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
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DR EMBL; CP002506; ADW76343.1; -; Genomic_DNA.
DR RefSeq; YP_004215470.1; NC_015062.1.
DR EnsemblBacteria; ADW76343; ADW76343; Rahaq_4763.
DR GeneID; 10215878; -.
DR KEGG; rah:Rahaq_4763; -.
DR PATRIC; 47407781; VBIRahSp167412_4728.
DR HOGENOM; HOG000050222; -.
DR KO; K00077; -.
DR BioCyc; RSP741091:GHHP-463-MONOMER; -.
DR UniPathway; UPA00028; UER00004.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.1040.10; -; 1.
DR Gene3D; 3.40.50.720; -; 1.
DR InterPro; IPR008927; 6-PGluconate_DH_C-like.
DR InterPro; IPR003710; ApbA.
DR InterPro; IPR013752; ApbA_C.
DR InterPro; IPR013332; ApbA_N.
DR InterPro; IPR013328; DH_multihelical.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6DGDH_C_like; 1.
DR TIGRFAMs; TIGR00745; apbA_panE; 1.
PE 3: Inferred from homology;
KW Complete proteome; NADP; Oxidoreductase; Pantothenate biosynthesis;
KW Plasmid; Signal.
FT SIGNAL 1 23 Potential.
FT CHAIN 24 307 Potential.
FT /FTId=PRO_5000703766.
SQ SEQUENCE 307 AA; 33367 MW; 884D3995545E7995 CRC64;
MRILVVGAGA TGGYFGARLA QAGQDVTFLL REKRALVVEQ NGLTIHSPHG DFHFQPNVLQ
ASQLTGPYDL ILLTVKSFGL EAAMKDIAPV VGENTMVMPV LNGMKHMETL SLRFGEHALI
GGLCKINATL DTDGHIHQMT PMHQIIYGEL SGEKTERILK VDQAFQSADI EAVLSETIIS
DLWEKWLLLS SFGAITCTMR GNIGQVASEP GGTEFANAIV TEALTTMKAF GYAERAAAVA
KVREAVTDKS SPQTSSMYRD MMQGYPIEAE QIIGDLVERA TRVGITIPLL QAAYTHLCVY
QKNGVKQ
//
