ID E9AF25_LEIMA Unreviewed; 1420 AA.
AC E9AF25;
DT 05-APR-2011, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 1.
DT 13-SEP-2023, entry version 57.
DE RecName: Full=EF-hand domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LMJF_35_2030 {ECO:0000313|EMBL:CBZ12829.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12829.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CBZ12829.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CBZ12829.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796431; CBZ12829.1; -; Genomic_DNA.
DR RefSeq; XP_003722595.1; XM_003722547.1.
DR EnsemblProtists; CBZ12829; CBZ12829; LMJF_35_2030.
DR GeneID; 12982499; -.
DR KEGG; lma:LMJF_35_2030; -.
DR VEuPathDB; TriTrypDB:LmjF.35.2030; -.
DR VEuPathDB; TriTrypDB:LMJFC_350027600; -.
DR VEuPathDB; TriTrypDB:LMJLV39_350026800; -.
DR VEuPathDB; TriTrypDB:LMJSD75_350026100; -.
DR eggNOG; ENOG502SK9B; Eukaryota.
DR HOGENOM; CLU_253148_0_0_1; -.
DR InParanoid; E9AF25; -.
DR OMA; WLRYACR; -.
DR Proteomes; UP000000542; Chromosome 35.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 257..292
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 937..978
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 138..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1420 AA; 151269 MW; C5DEABA37DF801F3 CRC64;
MPSCVFTRTQ VLESLSDEDA RQEAESIPEF IYFFLRDVFL AVDEDGDGYV TGDAVSRLFP
ALAPVRATKD AASCPAASSL MTPTVHPTWW SPTSYVAPTR CAAASQQRPL DLCGFMQTYW
PMVSDKMAHF VGDTWSRHSS DNLSDSRGQR ASVNQQPILS PSPFRDVSAS PLREQPTSPL
AAFVTGGRLA PSPVCGSSPL MERETVSPEQ HRLYREAVRC LWTSSCPLSP HALTPSPAPS
VPSPMLLPCP QRLLTESDME ELLVAFSYLD RNHSGYVGVA DVAAALRSLL RAAACAGQAI
VSTDTPAEVS DEVLQLANAM LRMALSSTTT ADEAVATQGV PASSAPSSSS GSPAVPSSSR
SSPCVSWTAF ARSFQCDTGA FPAELIAWCA ACARASRELP ARALATSPQW MSPVECAYVQ
QLLVSYVDLL CAEKGSVSPH PSSTATEKAQ PVPAAALSPR LSVNTHFTKK PPQSCGSAGT
CGDRRHSRYV CQTHATAAAL QQWCQCANAQ AKHLAESDMN TVPLTLLEAS LRRDLQAFLF
PKAFEFSAAA GAALAEVLEH HVQAVCALAQ GAARLPALCH SPNARMEGKA SALRGLAGHC
WESVHVDLDK LVDVITADPR YLQLEVLVPL ESRLTAVVDA ARHHPRRLVE EAVRLISVFV
HSARLGDSEL ADVLELRRAL STVSPSLARL ITGATSFCEG RLRLEECMIT ISTHVLSVPP
PLPVAVFPAF AGSVLPSAPV TKHDDAVMAL CDHPCYAMLQ DTRLLKASHG WLRYACRRMP
PREQRTVIDA LRLSCGSSSR GGSLFEAAAR GFGVILDARL DNREQQRSLS ACDVYSAMLP
RVRASCWVCR MDPVVAAHAT LVLIAASGSA DMTDLTEESV WWAGVHTLLG QWVHAQHSRR
CLLESADAWA MDAIKCTAAE LGLPCCRAVS QVLSHLPVAS STASRVVVVE EEELTQSLSC
VVESLSLWAT PPSANPEWQS SSAAACARLV DTLVGSCPRR DSTRVDVSAL LRRWLEAYPL
PLPVTHVSLC CAVEEVGSVY YTLKRLAASE EAQRRRSETP AGGAAAPPRT VSEGRATATA
ASRQVSSAPV VTGISPVCLS ELLENEDVLL ALYAVSPAEA VGVWGGALCH LGALLRPVLL
SSTGVRVSLY KLSGRSSESE GAVATAVPSS TSSPRPSKAI SHRNGGQSSL ADAILSMAVP
ASLQHAVAQL FACVDVEGTG AVTEDQLRSH RSRVPASARY GWHRFVTAVC SSSAMTSLPS
SSSRTTPCSL ISGGLSAGVL RSHWWSRRRR AAVATLSCAG EAQPQAEQAS CSSVATQRTD
DDVVTTYSLG DMLMRMAELR VCVQAQLLEE SSTRAKAEAS VFVSRKSGLA LTRAITDADS
PLSTAVGQKA AVSSPPTAGT AQWWATYLEE LCRSYSPLAL
//