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Database: UniProt/TrEMBL
Entry: E9AF25_LEIMA
LinkDB: E9AF25_LEIMA
Original site: E9AF25_LEIMA 
ID   E9AF25_LEIMA            Unreviewed;      1420 AA.
AC   E9AF25;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   13-SEP-2023, entry version 57.
DE   RecName: Full=EF-hand domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=LMJF_35_2030 {ECO:0000313|EMBL:CBZ12829.1};
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664 {ECO:0000313|EMBL:CBZ12829.1, ECO:0000313|Proteomes:UP000000542};
RN   [1] {ECO:0000313|EMBL:CBZ12829.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
RN   [2] {ECO:0000313|EMBL:CBZ12829.1, ECO:0000313|Proteomes:UP000000542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR796431; CBZ12829.1; -; Genomic_DNA.
DR   RefSeq; XP_003722595.1; XM_003722547.1.
DR   EnsemblProtists; CBZ12829; CBZ12829; LMJF_35_2030.
DR   GeneID; 12982499; -.
DR   KEGG; lma:LMJF_35_2030; -.
DR   VEuPathDB; TriTrypDB:LmjF.35.2030; -.
DR   VEuPathDB; TriTrypDB:LMJFC_350027600; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_350026800; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_350026100; -.
DR   eggNOG; ENOG502SK9B; Eukaryota.
DR   HOGENOM; CLU_253148_0_0_1; -.
DR   InParanoid; E9AF25; -.
DR   OMA; WLRYACR; -.
DR   Proteomes; UP000000542; Chromosome 35.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR007110; Ig-like_dom.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT   DOMAIN          257..292
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          937..978
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          138..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1052..1080
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1161..1185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1420 AA;  151269 MW;  C5DEABA37DF801F3 CRC64;
     MPSCVFTRTQ VLESLSDEDA RQEAESIPEF IYFFLRDVFL AVDEDGDGYV TGDAVSRLFP
     ALAPVRATKD AASCPAASSL MTPTVHPTWW SPTSYVAPTR CAAASQQRPL DLCGFMQTYW
     PMVSDKMAHF VGDTWSRHSS DNLSDSRGQR ASVNQQPILS PSPFRDVSAS PLREQPTSPL
     AAFVTGGRLA PSPVCGSSPL MERETVSPEQ HRLYREAVRC LWTSSCPLSP HALTPSPAPS
     VPSPMLLPCP QRLLTESDME ELLVAFSYLD RNHSGYVGVA DVAAALRSLL RAAACAGQAI
     VSTDTPAEVS DEVLQLANAM LRMALSSTTT ADEAVATQGV PASSAPSSSS GSPAVPSSSR
     SSPCVSWTAF ARSFQCDTGA FPAELIAWCA ACARASRELP ARALATSPQW MSPVECAYVQ
     QLLVSYVDLL CAEKGSVSPH PSSTATEKAQ PVPAAALSPR LSVNTHFTKK PPQSCGSAGT
     CGDRRHSRYV CQTHATAAAL QQWCQCANAQ AKHLAESDMN TVPLTLLEAS LRRDLQAFLF
     PKAFEFSAAA GAALAEVLEH HVQAVCALAQ GAARLPALCH SPNARMEGKA SALRGLAGHC
     WESVHVDLDK LVDVITADPR YLQLEVLVPL ESRLTAVVDA ARHHPRRLVE EAVRLISVFV
     HSARLGDSEL ADVLELRRAL STVSPSLARL ITGATSFCEG RLRLEECMIT ISTHVLSVPP
     PLPVAVFPAF AGSVLPSAPV TKHDDAVMAL CDHPCYAMLQ DTRLLKASHG WLRYACRRMP
     PREQRTVIDA LRLSCGSSSR GGSLFEAAAR GFGVILDARL DNREQQRSLS ACDVYSAMLP
     RVRASCWVCR MDPVVAAHAT LVLIAASGSA DMTDLTEESV WWAGVHTLLG QWVHAQHSRR
     CLLESADAWA MDAIKCTAAE LGLPCCRAVS QVLSHLPVAS STASRVVVVE EEELTQSLSC
     VVESLSLWAT PPSANPEWQS SSAAACARLV DTLVGSCPRR DSTRVDVSAL LRRWLEAYPL
     PLPVTHVSLC CAVEEVGSVY YTLKRLAASE EAQRRRSETP AGGAAAPPRT VSEGRATATA
     ASRQVSSAPV VTGISPVCLS ELLENEDVLL ALYAVSPAEA VGVWGGALCH LGALLRPVLL
     SSTGVRVSLY KLSGRSSESE GAVATAVPSS TSSPRPSKAI SHRNGGQSSL ADAILSMAVP
     ASLQHAVAQL FACVDVEGTG AVTEDQLRSH RSRVPASARY GWHRFVTAVC SSSAMTSLPS
     SSSRTTPCSL ISGGLSAGVL RSHWWSRRRR AAVATLSCAG EAQPQAEQAS CSSVATQRTD
     DDVVTTYSLG DMLMRMAELR VCVQAQLLEE SSTRAKAEAS VFVSRKSGLA LTRAITDADS
     PLSTAVGQKA AVSSPPTAGT AQWWATYLEE LCRSYSPLAL
//
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