GenomeNet

Database: UniProt/TrEMBL
Entry: E9DRD9_METAQ
LinkDB: E9DRD9_METAQ
Original site: E9DRD9_METAQ 
ID   E9DRD9_METAQ            Unreviewed;       987 AA.
AC   E9DRD9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=MAC_00308 {ECO:0000313|EMBL:EFY93817.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY93817.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY93817.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z.,
RA   Hu X., Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W.,
RA   Wang S., Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y.,
RA   Feng M.G., Xia Y., Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; GL698470; EFY93817.1; -; Genomic_DNA.
DR   RefSeq; XP_007806648.1; XM_007808457.1.
DR   ProteinModelPortal; E9DRD9; -.
DR   EnsemblFungi; EFY93817; EFY93817; MAC_00308.
DR   GeneID; 19244619; -.
DR   KEGG; maw:MAC_00308; -.
DR   InParanoid; E9DRD9; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002499};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EFY93817.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN      436    559       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      727    810       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      910    986       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   987 AA;  112271 MW;  0ECA5D7A2BDF5F14 CRC64;
     MSGFNRAKSP DADAEREEEM QYGAVGLTKE ELEEKYPNRP HNHSKTLRFS ELFLQLFNPL
     NENKKQPAAG PARKKGPHGA TSLSPQEQRR HIIERFINRW RKEVGNDFYP ALRLILPDKD
     RDRGVYGLKE NAIGKLLVKL MKIDKNSEDG YNLLHWKLPG QTMAARLAGD FAGRCYEVIS
     KRPMRIEVGD MTIAEVNEQL DKLAASAGEA ENLRVFETFY NRMNAEEMLW LIRIILKQMK
     VGATEKTFLY LWHPDGETLF SVSSSLRRVC WELYDPDVRL EQEEAGISLM QCFQPQLAQF
     QMPASFQKMT ELLRPTEDDP EFWIEEKLDG ERMQMHMVAD AAHPGGKRFC FWSRKAKDYT
     YLYGDGVLDE NSSLTRHLKD AFAPGVRNLI LDGEMITWDM AVDKIVPFGT LKTAAIAEQQ
     NKSGSDASGH RPVYRVFDIL YLNDKPLTQY TLRDRHRALE KAIKPVHRRL EIHTHKSATT
     ADAIEPMLRE VVANASEGLV LKNPRSMYRL NSRNDDWLKV KPEYMSEFGE SLDCLVIGGY
     YGSGKRGGTL SSFLCGLRVS QNHIQAGDNP EKCYSFFKVG GGFRGEDYAE IRHRTEGKWV
     EWDRRKPPTE YIELGGGESK QFERPDVWIR PRDSVVLSAK AASVGPSDSF AMGYTLRFPR
     FRRLRLDRAW DSALSVDEFE ELKRQVDREA KEKAMTVEDR RRRNPKRAKR SVVIVGEDAT
     AVEFRGEASH VFDGLEFCVL SESLKPYKKT KAQLEAVIKE NGGTISQRAV AGTNMVLIAD
     KNVVKVASLI KGGNVNIIRP KWIRDCVAQG GDFLLPYEEG HLFHATEELR AIAAKNTDMY
     GDSYARDVSV DELRGILGGM PKVEEAFDGD HFLAELEERG KGITELRGFM MRRCVVHFRA
     VDGVNGSMGK LVHYVMYTGG KVVDSLREGV THVVVMGDDP MEVGETADTV RRQVSSWAKV
     PRVLGDGWVL DCWKERTLLD EEKYMIS
//
DBGET integrated database retrieval system