ID   E9E6H7_METAQ            Unreviewed;       649 AA.
AC   E9E6H7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=histone deacetylase {ECO:0000256|ARBA:ARBA00012111};
DE            EC=3.5.1.98 {ECO:0000256|ARBA:ARBA00012111};
GN   ORFNames=MAC_05475 {ECO:0000313|EMBL:EFY88423.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY88423.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY88423.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y., Feng M.G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006457}.
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DR   EMBL; GL698511; EFY88423.1; -; Genomic_DNA.
DR   RefSeq; XP_007811815.1; XM_007813624.1.
DR   AlphaFoldDB; E9E6H7; -.
DR   STRING; 655827.E9E6H7; -.
DR   GeneID; 19249786; -.
DR   KEGG; maw:MAC_05475; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   HOGENOM; CLU_007727_0_0_1; -.
DR   InParanoid; E9E6H7; -.
DR   OMA; EHRWDKH; -.
DR   OrthoDB; 1327607at2759; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:1902494; C:catalytic complex; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0004407; F:histone deacetylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   CDD; cd10004; RPD3-like; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF13; HISTONE DEACETYLASE HDAC1; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499}.
FT   DOMAIN          43..332
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          388..649
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..442
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        465..508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..541
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..649
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   649 AA;  72301 MW;  F664C6DD35800C94 CRC64;
     MGDSNLAQAQ AQLGSVALNG SSPKKVAYFY DSDIGNYAYV TGHPMKPHRI RLAHSLIMQY
     NLYQKMEIYR AKPATRGEMT QFHTDDYIDF LQKVTPDNMD SYMREQGKYN VGDDCPVFDG
     LFEFCGISAG GSMEGAARLN RQKCDIAVNW AGGLHHAKKC EASGFCYVND IVLGILELLR
     FMKRVLYIDI DVHHGDGVEE AFYTTDRVMT VSFHKYGEYF PGTGELRDIG IGQGKHYAVN
     FPLRDGITDQ TYKSIFEPVI ESVMKYYQPE AVVLQCGGDS LSGDRLGCFN LSMDGHANCV
     NYVKSFGLPT LVLGGGGYTM RNVARTWAYE TGVLVGQEMD RTLPYNEYYE YYAPDFELNV
     RASNMENSNS REYLDKITAA VIDNLRQTGP APSVQMQDVP RKPFGGMTDE EEAELDDLDE
     DENKDVRMTE HRWDKHVENG AEFEASDDDE MAAASGATRS NGNKRTFNDF KDADAAEDSR
     SKSLREKQDD NSKDAVEAET HDVNDDTIED VGAMEEQENQ AAEQEETEDQ DSKEKKVDAD
     GDVGMAYSSV ADEATIKKEE GEPESVPEDE KESEIPTEEK ASVAEPDKPA EAEETTEAKA
     SDKPAVETAS EEPVQKDDEA QAAAEAETEP MEVDDKEKFE DKAEDDSSK
//