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Database: UniProt/TrEMBL
Entry: E9E6H7_METAQ
LinkDB: E9E6H7_METAQ
Original site: E9E6H7_METAQ 
ID   E9E6H7_METAQ            Unreviewed;       649 AA.
AC   E9E6H7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   20-DEC-2017, entry version 31.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   ORFNames=MAC_05475 {ECO:0000313|EMBL:EFY88423.1};
OS   Metarhizium acridum (strain CQMa 102).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=655827 {ECO:0000313|Proteomes:UP000002499};
RN   [1] {ECO:0000313|EMBL:EFY88423.1, ECO:0000313|Proteomes:UP000002499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CQMa 102 {ECO:0000313|EMBL:EFY88423.1,
RC   ECO:0000313|Proteomes:UP000002499};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z.,
RA   Hu X., Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W.,
RA   Wang S., Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y.,
RA   Feng M.G., Xia Y., Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
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DR   EMBL; GL698511; EFY88423.1; -; Genomic_DNA.
DR   RefSeq; XP_007811815.1; XM_007813624.1.
DR   ProteinModelPortal; E9E6H7; -.
DR   EnsemblFungi; EFY88423; EFY88423; MAC_05475.
DR   GeneID; 19249786; -.
DR   KEGG; maw:MAC_05475; -.
DR   InParanoid; E9E6H7; -.
DR   KO; K06067; -.
DR   OrthoDB; EOG092C1END; -.
DR   Proteomes; UP000002499; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 2.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002499};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002499};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290}.
FT   DOMAIN       43    333       Hist_deacetyl. {ECO:0000259|Pfam:
FT                                PF00850}.
FT   COILED      514    534       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   649 AA;  72301 MW;  F664C6DD35800C94 CRC64;
     MGDSNLAQAQ AQLGSVALNG SSPKKVAYFY DSDIGNYAYV TGHPMKPHRI RLAHSLIMQY
     NLYQKMEIYR AKPATRGEMT QFHTDDYIDF LQKVTPDNMD SYMREQGKYN VGDDCPVFDG
     LFEFCGISAG GSMEGAARLN RQKCDIAVNW AGGLHHAKKC EASGFCYVND IVLGILELLR
     FMKRVLYIDI DVHHGDGVEE AFYTTDRVMT VSFHKYGEYF PGTGELRDIG IGQGKHYAVN
     FPLRDGITDQ TYKSIFEPVI ESVMKYYQPE AVVLQCGGDS LSGDRLGCFN LSMDGHANCV
     NYVKSFGLPT LVLGGGGYTM RNVARTWAYE TGVLVGQEMD RTLPYNEYYE YYAPDFELNV
     RASNMENSNS REYLDKITAA VIDNLRQTGP APSVQMQDVP RKPFGGMTDE EEAELDDLDE
     DENKDVRMTE HRWDKHVENG AEFEASDDDE MAAASGATRS NGNKRTFNDF KDADAAEDSR
     SKSLREKQDD NSKDAVEAET HDVNDDTIED VGAMEEQENQ AAEQEETEDQ DSKEKKVDAD
     GDVGMAYSSV ADEATIKKEE GEPESVPEDE KESEIPTEEK ASVAEPDKPA EAEETTEAKA
     SDKPAVETAS EEPVQKDDEA QAAAEAETEP MEVDDKEKFE DKAEDDSSK
//
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