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Database: UniProt/TrEMBL
Entry: E9FCD6_METRA
LinkDB: E9FCD6_METRA
Original site: E9FCD6_METRA 
ID   E9FCD6_METRA            Unreviewed;       987 AA.
AC   E9FCD6;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   07-JUN-2017, entry version 35.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=MAA_09935 {ECO:0000313|EMBL:EFY94634.1};
OS   Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS   anisopliae (strain ARSEF 23)).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Metarhizium.
OX   NCBI_TaxID=655844 {ECO:0000313|EMBL:EFY94634.1, ECO:0000313|Proteomes:UP000002498};
RN   [1] {ECO:0000313|EMBL:EFY94634.1, ECO:0000313|Proteomes:UP000002498}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.H., Zhang Y., Xiao G., Shang Y., Duan Z.,
RA   Hu X., Xie X.Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W.,
RA   Wang S., Zhong Y., Ma L.J., St Leger R.J., Zhao G.P., Pei Y.,
RA   Feng M.G., Xia Y., Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2] {ECO:0000313|EMBL:EFY94634.1, ECO:0000313|Proteomes:UP000002498}
RP   GENOME REANNOTATION.
RC   STRAIN=ARSEF 23 / ATCC MYA-3075 {ECO:0000313|Proteomes:UP000002498};
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and
RT   host adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFY94634.1}.
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DR   EMBL; ADNJ02000011; EFY94634.1; -; Genomic_DNA.
DR   RefSeq; XP_007826124.1; XM_007827933.1.
DR   EnsemblFungi; EFY94634; EFY94634; MAA_09935.
DR   GeneID; 19264221; -.
DR   KEGG; maj:MAA_09935; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000002498; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF84; PTHR10459:SF84; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002498};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EFY94634.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002498}.
FT   DOMAIN      436    559       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      727    810       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      910    986       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   987 AA;  111729 MW;  18ADF0F1B352AD54 CRC64;
     MSGFNRAKSP DADAEREEEM QYGAVGLTKE ELEEKYPNRP HNHSKTLLFS ELFLQLFNPL
     NENKKQPAAG PARKKGPHGA TTLSPQEQRR HIIERFINRW RKEVGNDFYP ALRLILPDKD
     RDRGVYGLKE NAIGKLLVKL IKIDKNSEDG YNLLHWKLPG QTMAARLAGD FAGRCYEVIS
     KRPMRIEVGD MTIAEVNEQL DKLAASAGEA ENLRVFETFY NRMNAEEMLW LIRIILKQMK
     VGATEKTFLY LWHPDGETLF SVSSSLRRVC WELYDPDVRL EQEEAGISLM QCFQPQLAQF
     QMPASFQKMT ELLRPTEDDA EFWIEEKLDG ERMQMHMVAD ASHPGGKRFC FWSRKAKDYT
     YLYGDGVLDE NSSLTRHLKD AFAPGVRNLI LDGEMITWDM AVDKIVPFGT LKTAAIAEQQ
     NKSGSDASGH RPLYRVFDIV YLNDKPLTQY TLRDRHRALE KAIRPVHRRL EIHAYKSATT
     ADAIEPMLRE VVASASEGLV LKNPRSMYRL NSRNDDWLKV KPEYMSEFGE SLDCLVIGGY
     YGSGKRGGTL SSFLCGLRVS PNHIQAGDNP EKCYSFFKVG GGFRGEDYAE IRHRTEGKWV
     EWDRRNPPTE YVELGGGEGR QLERPDVWIR PRDSVVLSAK AASVGPSDSF AMGYTLRFPR
     FRRLRLDRAW DSALSVDEFE ELKRQVDREA REKAMTVEDR KRRHPKRAKR SVVIAGEDAT
     AVASRGAASH VFDGLEFCVL SESLRPWRKT KAQLEAVIKE NGGTVSQRAV AGTRMVLVAD
     KNVVKVASLI KGGNANIIRP KWIRDCVEQG GDFLLPYEEG HLFHATEALG AVAAKNTDMY
     GDSYARDVSV DELRGIVGAM PKVEEAFDGD RFLAELEERG KGIAELRGFM MRRCVVHFRA
     VDGVDGPTGK LVHYVMYTGG KVVDSLREGV THVVVVGDDA MQVGEAADTA RRQVSSWAKV
     PRVLGHGWVL DCWKERTLLD EEKYVIS
//
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