GenomeNet

Database: UniProt/TrEMBL
Entry: E9G1N7_DAPPU
LinkDB: E9G1N7_DAPPU
Original site: E9G1N7_DAPPU 
ID   E9G1N7_DAPPU            Unreviewed;      1373 AA.
AC   E9G1N7;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   25-OCT-2017, entry version 29.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   ORFNames=DAPPUDRAFT_307838 {ECO:0000313|EMBL:EFX86779.1};
OS   Daphnia pulex (Water flea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=6669 {ECO:0000313|Proteomes:UP000000305};
RN   [1] {ECO:0000313|EMBL:EFX86779.1, ECO:0000313|Proteomes:UP000000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21292972; DOI=10.1126/science.1197761;
RA   Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA   Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K.,
RA   Bauer D.J., Caceres C.E., Carmel L., Casola C., Choi J.H.,
RA   Detter J.C., Dong Q., Dusheyko S., Eads B.D., Frohlich T.,
RA   Geiler-Samerotte K.A., Gerlach D., Hatcher P., Jogdeo S.,
RA   Krijgsveld J., Kriventseva E.V., Kultz D., Laforsch C., Lindquist E.,
RA   Lopez J., Manak J.R., Muller J., Pangilinan J., Patwardhan R.P.,
RA   Pitluck S., Pritham E.J., Rechtsteiner A., Rho M., Rogozin I.B.,
RA   Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA   Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D.,
RA   Tu H., Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y.,
RA   Shaw J.R., Andrews J., Crease T.J., Tang H., Lucas S.M.,
RA   Robertson H.M., Bork P., Koonin E.V., Zdobnov E.M., Grigoriev I.V.,
RA   Lynch M., Boore J.L.;
RT   "The ecoresponsive genome of Daphnia pulex.";
RL   Science 331:555-561(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 2 Zn(2+) ions per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; GL732529; EFX86779.1; -; Genomic_DNA.
DR   STRING; 6669.DappuP307838; -.
DR   EnsemblMetazoa; EFX86779; EFX86779; DAPPUDRAFT_307838.
DR   KEGG; dpx:DAPPUDRAFT_307838; -.
DR   eggNOG; KOG3690; Eukaryota.
DR   eggNOG; ENOG410XPJ3; LUCA.
DR   InParanoid; E9G1N7; -.
DR   KO; K01283; -.
DR   OMA; VTMEQLF; -.
DR   PhylomeDB; E9G1N7; -.
DR   Proteomes; UP000000305; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   CDD; cd06461; M2_ACE; 2.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 2.
DR   Pfam; PF01401; Peptidase_M2; 2.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000305};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
FT   TRANSMEM   1327   1346       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   1373 AA;  158129 MW;  54CE7AD3A08CFB10 CRC64;
     MRHSLIGEGT IERSTIALSD LSIIYFTNVW SPTTTFFNCR LKEKDVMERL VSSRRPVSRI
     FVTFLLIAAS AKAQLNTNED EATQFLEDLD PIYLKEANTQ MTTRWQSITD ITEEHSQAEI
     AANVNYLAFQ KETWGDVTKF DYSGFNDVDV KREFQYLNII GPAALDTADA QRYTQLSSEM
     ETIYSSAKVC KQDDPTVCMP LDPDLTEIMA TSTNYTELEY VWTQWREEAG KPVRQKYIEF
     VALNNKAATL NGYKDMGSLW NEYYLYEGYS EDEFKAAIEE LWQTVKPLYE QLYTYVRRIL
     STTIYKDQLQ RYGRLPAHVL GNMWAQSWGN IAKHVLPYPD APAVDATPEM IAQGYTAKKM
     FELSEKFFYD LGLDNMTKTF WDLSMIERPD DGREVVCHAS AEEFFFGPGD DTNFREDWRI
     KMCTTITQED FVTVHHEMGH IQYFMNYRNQ HWVFRNGANP GFHEAIGDTI ALAVSTPAHL
     KKLGLLPATT SAKTKPRDAK LPELPAGVSE QDLNYLLSQA LEKIAFIPFG YLMDKWRWSV
     FDGSTNDTNL NENWWKLRQE LQGLRAPIYR NESDFDPGAK YHIPANVEYI RYFVSYIVQF
     QFYESLCKEA GQFDPANPEL PLYKCDFDGS KAAGAKLKYD ATFNDIIDFL KSKFSPKKSF
     RALLEPGFSK PWPDALEALT GSRVMDATSL LAYFDPLMQW LKEANAGDCL GWECEAFAAD
     YMMNDYETTT SYLYNQATIA EWNYETNLTD ANGQNSTEWS VKVANHIKQS WEEYITQFEY
     ETFVDESLKR QLQLLQSLGV AALSDEDLTN RTTVINNMMN QYSSAKICPY QKPSCKDEEK
     LALEPDIESI LATSTDYDEL NYVWSEWRKI ASRPMIHDYE QYVELNNKVA EVNGKEDMSV
     LWKEPYETEN FQQQLEKILN ETKPFYDVLH AYTRMKLRER YGEDKFPKDK SPIPASVLGN
     MWAQTWENLY DLLAPYPDAP TVDVTQEMNN QKWTARKMFE VAEEFYTSLG LLPMPTCYGK
     DSMIEKPTDG REVVCHASAW DFSDGKDFRI KMCTGIDMAD LITVHHEQGH IQYDEQYKDQ
     PVTFRDGANP GFHEAIGDVM ALSVATPKHL SKIELLIDYT PSIETDLNFL MKTALEKVTF
     LPFAYVMDSW RWEVFQGKYD SSNWMERWMH LTETYQGIVP PSIRYQDDFD PGAKYHIAAD
     VEYSRYFVAN VLQFQIHKAL CIVAGEFDPV DPEKPLYRCD IYQNKDAGKI METLLKAGLS
     KPWRETLNET IGASELDSSA VIDYFKPLQA HLEKEIKDKE EIGWVSKYQE FYVDGERYPV
     GDNTVPIIVG SVLAALVVIV IVAYFIGRSR NNKRRKAAAA LNGNDNPTAV TLE
//
DBGET integrated database retrieval system