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Database: UniProt/TrEMBL
Entry: E9GIV2_DAPPU
LinkDB: E9GIV2_DAPPU
Original site: E9GIV2_DAPPU 
ID   E9GIV2_DAPPU            Unreviewed;       626 AA.
AC   E9GIV2;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   05-JUL-2017, entry version 31.
DE   RecName: Full=Angiotensin-converting enzyme {ECO:0000256|RuleBase:RU361144};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361144};
GN   ORFNames=DAPPUDRAFT_243454 {ECO:0000313|EMBL:EFX80591.1};
OS   Daphnia pulex (Water flea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=6669 {ECO:0000313|Proteomes:UP000000305};
RN   [1] {ECO:0000313|EMBL:EFX80591.1, ECO:0000313|Proteomes:UP000000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21292972; DOI=10.1126/science.1197761;
RA   Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA   Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K.,
RA   Bauer D.J., Caceres C.E., Carmel L., Casola C., Choi J.H.,
RA   Detter J.C., Dong Q., Dusheyko S., Eads B.D., Frohlich T.,
RA   Geiler-Samerotte K.A., Gerlach D., Hatcher P., Jogdeo S.,
RA   Krijgsveld J., Kriventseva E.V., Kultz D., Laforsch C., Lindquist E.,
RA   Lopez J., Manak J.R., Muller J., Pangilinan J., Patwardhan R.P.,
RA   Pitluck S., Pritham E.J., Rechtsteiner A., Rho M., Rogozin I.B.,
RA   Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA   Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D.,
RA   Tu H., Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y.,
RA   Shaw J.R., Andrews J., Crease T.J., Tang H., Lucas S.M.,
RA   Robertson H.M., Bork P., Koonin E.V., Zdobnov E.M., Grigoriev I.V.,
RA   Lynch M., Boore J.L.;
RT   "The ecoresponsive genome of Daphnia pulex.";
RL   Science 331:555-561(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361144};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU361144};
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|RuleBase:RU361144}.
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DR   EMBL; GL732547; EFX80591.1; -; Genomic_DNA.
DR   STRING; 6669.DappuP243454; -.
DR   EnsemblMetazoa; EFX80591; EFX80591; DAPPUDRAFT_243454.
DR   KEGG; dpx:DAPPUDRAFT_243454; -.
DR   eggNOG; KOG3690; Eukaryota.
DR   eggNOG; ENOG410XPJ3; LUCA.
DR   InParanoid; E9GIV2; -.
DR   KO; K01283; -.
DR   OMA; EAKQYDP; -.
DR   PhylomeDB; E9GIV2; -.
DR   Proteomes; UP000000305; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   CDD; cd06461; M2_ACE; 1.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; PTHR10514; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   PRINTS; PR00791; PEPDIPTASEA.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|RuleBase:RU361144};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000305};
KW   Glycoprotein {ECO:0000256|RuleBase:RU361144};
KW   Hydrolase {ECO:0000256|RuleBase:RU361144};
KW   Metal-binding {ECO:0000256|RuleBase:RU361144};
KW   Metalloprotease {ECO:0000256|RuleBase:RU361144};
KW   Protease {ECO:0000256|RuleBase:RU361144};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000305};
KW   Zinc {ECO:0000256|RuleBase:RU361144}.
SQ   SEQUENCE   626 AA;  72361 MW;  9CA7CF69635B106F CRC64;
     MDFSSSTTSV QIRSTTACNV RTGEYAVLRP KRTIVEDEAL AREYLSAHNY KSSDMCYKTN
     VAEWKFASDI TDEKERLKLE QSLVAARFEK EAWKNITSFN WKPFTDPDLK RKFKLLSVLG
     PSALPEDKLT QYRKTIDAME KIYSTAKICS FTNPGDCGMN LDPEITEKMS KSRNFDELKH
     VWQQWHEQSG GKMRDHYEKF VELSNEAARM NNFSDTGAYW LRNYESDTFK EDIEGLWQTI
     KPFYLQLHAY VRAKLRAHYG EDKVPNNQPI PAHLLGNMWA QSWGNIDDLV TPYPGKTSID
     VTPEMLKQGY TPKKMFEMSE EFFTSMGLLP TPPEFWSGSI IEKLVGKEMV CHASAWDFCN
     GKDFRIKQCT KVTMEDFIVV HHEMGHIQYF LQYKNLPLVY RDGANSGFHE AVGDSLALSV
     QTTKHLKEIG LLDKSTPQDQ EATINYLLAT ALEKIAFFPF AYIMDKWRWD VFDGSVKSTD
     YNGHWWKLRE KYQGIRSPVT RSENDFDPGA KYHIAANVEY IRYFVSFVIQ FQFYKSLCMT
     AGQYDPHNPS QPLHECDFYR NKEAGAKLGA MLTMGASRPW PEAMRAVTGQ DRMDASAFRE
     YFKPLEVWLI AKNKELGEPV GWDSDQ
//
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