ID F0Q8E2_ACIAP Unreviewed; 324 AA.
AC F0Q8E2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 01-MAY-2013, entry version 16.
DE RecName: Full=Homoserine kinase;
DE Short=HK;
DE Short=HSK;
DE EC=2.7.1.39;
GN Name=thrB; OrderedLocusNames=Acav_3238;
OS Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB
OS 1011).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Acidovorax.
OX NCBI_TaxID=643561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19860 / DSM 7227 / JCM 20985 / NCPPB 1011;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA Pitluck S., Chertkov O., Held B., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G.,
RA Pagani I., Gordon S., Woyke T.;
RT "Complete sequence of Acidovorax avenae subsp. avenae ATCC 19860.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-
CC homoserine.
CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC threonine from L-aspartate: step 4/5.
CC -!- SIMILARITY: Belongs to the pseudomonas-type ThrB family.
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DR EMBL; CP002521; ADX47140.1; -; Genomic_DNA.
DR RefSeq; YP_004235707.1; NC_015138.1.
DR EnsemblBacteria; ADX47140; ADX47140; Acav_3238.
DR GeneID; 10308181; -.
DR KEGG; aaa:Acav_3238; -.
DR PATRIC; 46841387; VBIAciAve68977_3318.
DR KO; K02204; -.
DR OMA; PDNVFFL; -.
DR BioCyc; AAVE643561:GHRD-3280-MONOMER; -.
DR UniPathway; UPA00050; UER00064.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004413; F:homoserine kinase activity; IEA:HAMAP.
DR GO; GO:0009088; P:threonine biosynthetic process; IEA:HAMAP.
DR HAMAP; MF_00301; Homoser_kinase_2; 1; -.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR005280; Homoserine_kinase_ThrB.
DR InterPro; IPR011009; Kinase-like_dom.
DR Pfam; PF01636; APH; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR TIGRFAMs; TIGR00938; thrB_alt; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; ATP-binding; Complete proteome; Kinase;
KW Nucleotide-binding; Threonine biosynthesis; Transferase.
SQ SEQUENCE 324 AA; 36138 MW; 480027D2CBA07CF9 CRC64;
MAVFTEVSKK EARDLLRRLQ LGTLESLRGI EGGIENTNYF LTSDQGEYVL TLFERLTAEQ
LPFYLHLMKH LAQAGMPVPD PRGDRHGNIL HTVAGKPAAV VNKLPGRSQL APEPVHCAAV
GGMLARMHLA GRDYERRQPN LRGLAWWNET VPVVLPHIGE SQRTLLRSEL AYQNHVAASA
GYAALPRGPV HADLFRDNAM FDGEVLTGFF DFYFAGVDTW LFDLAVCLND WCIDWPTGLH
APGRATAMLD AYQAVRPLSA DERALLPAML RAGALRFWIS RLWDFHLPRE ASLLTPHDPT
HFERVLRGRI AQPLHVRAGG GFAE
//
