ID   F0S421_DESTD            Unreviewed;       206 AA.
AC   F0S421;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   03-APR-2013, entry version 11.
DE   RecName: Full=Thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=tmk; OrderedLocusNames=Dester_0954;
OS   Desulfurobacterium thermolithotrophum (strain DSM 11699 / BSA).
OC   Bacteria; Aquificae; Aquificales; Desulfurobacteriaceae;
OC   Desulfurobacterium.
OX   NCBI_TaxID=868864;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11699 / BSA;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S.,
RA   Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Mikhailova N.,
RA   Daligault H., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA   Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S.,
RA   Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Desulfurobacterium thermolithotrophum DSM
RT   11699.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR   EMBL; CP002543; ADY73593.1; -; Genomic_DNA.
DR   RefSeq; YP_004281652.1; NC_015185.1.
DR   EnsemblBacteria; ADY73593; ADY73593; Dester_0954.
DR   GeneID; 10270190; -.
DR   KEGG; dte:Dester_0954; -.
DR   PATRIC; 46942585; VBIDesThe167085_0991.
DR   KO; K00943; -.
DR   BioCyc; DTHE868864:GHGF-982-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   PANTHER; PTHR10344; PTHR10344; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW   Nucleotide-binding; Transferase.
FT   NP_BIND       7     14       ATP (By similarity).
SQ   SEQUENCE   206 AA;  23641 MW;  7C7456EC2B2EB3DD CRC64;
     MFITFEGIEG CGKSTQAKLL YDWFLKKGKE AILTREPGGT PAAEEIRNFI LRPRKETFPA
     FAELCLYMAA RGFHVENLIK PALKKGIWVV CDRFVDSTVA YQGYGRGINV ELIEKLNEEA
     TGNLKPDLTF LIDVPVEIGF SRIKRRDLDR MEQEEMDFHE RVRQGFLRIA EKNSERVIVI
     DGTKKVDEIF DEILNTLKKR GNINAL
//